The Moth Trap: How I came to see the lepidopteral light and how you can too
TL:DR – How to fall in love with moths and mothing.
Regular Sciencebase readers will know only too well that back in July 2018 I got hooked on moths. An enthusiastic friend lent me a moth trap he had built himself for his children many years ago. The trap is basically a wooden box with a plastic funnel and an ultraviolet light supported by stiff plastic vanes).
Moth trap
The UV light attracts the night-flying creatures, some of them bump into the vanes, drop into the funnel and then find a cozy corner in one of the empty egg cartons put inside the box before “lighting up”. The amateur, or indeed professi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - April 18, 2023 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs
125 I ’m Sorry Quotes to Help You Apologize (and Forgive Someone)
You know you shouldn’t have said that. Or done that.
And now you know you’re in the wrong.
I have been there many times myself and it’s no fun. You feel guilty and stupid for what you did or said.
You’re afraid about how this will affect your relationship, no matter if it’s with a family member, a friend or someone at work or in school.
So in this post I’d like to share the best timeless wisdom about apologies. 125 of the most helpful I’m sorry quotes.
I hope you’ll find something helpful here, like I did.
And if you want more useful inspiration then check out this post with quotes on forgiveness and this ...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 13, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Triggering the STING Pathway Suppresses Cancer Metastasis
Most cancers would become manageable if metastasis could be eliminated. A robust way to fully suppress metastasis across all forms of cancer would not be a cure in and of itself, but it would greatly reduce mortality and allow cancers to be managed or eliminated more readily, and with less trauma for the patient. On the way to a hypothetical end to metastasis, researchers are making inroads towards approaches that may at least reduce metastasis to some degree. These approaches often, as here, involve ways to enlist the immune system to more aggressively target and destroy metastatic cells before they can build a new tumor....
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Looking at the Connection Between Mitochondrial Dysfunction and Inflammation
Every cell contains hundreds of mitochondria, each with its own genome, mitochondrial DNA separate from that of the cell nucleus. The primary role of mitochondria is to generate chemical energy store molecules, adenosine triphosphate (ATP), used to power cell activities. Mitochondrial dysfunction with aging isn't just a loss of ATP generation and production of a harmful amount of reactive oxygen species, however. It can also be connected with chronic inflammation, as mislocalization of mitochondrial DNA can trigger sensors of the innate immune system to provide inflammatory signaling. Mitochondria are the descendants of an...
Source: Fight Aging! - April 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inhibiting the NLRP1 Inflammasome Reduces the Senescence-Associated Secretory Phenotype
A sizable portion of the chronic inflammation of aging is produced by the growing presence of senescent cells in tissues throughout the body. Senescent cells secrete a mix of pro-growth, pro-inflammatory signals (the senescence-associated secretory phenotype, SASP), useful when present in the short-term in the context of wound healing and suppression of cancer risk resulting from cell damage. When sustained over the long-term, however, this signaling becomes highly disruptive to tissue structure and function. The inflammatory mechanisms inside senescent cells that produce pro-inflammatory components of the SASP include the...
Source: Fight Aging! - March 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
poem
Poem #45Do you know that feeling when you finish a poem and you think you may have busted out a banger and it ’s cool as hell for a while, you ' re proud of yourself, you finally did it, you may have made something original and halfway decent for once, something someone else will read and perhaps be moved. But after a few weeks you start to waver. You lose confidence. Was it really any good? Sometimes you never read it again. Afraid to find out it really is shit. You missed the mark and there ’s no quick fix. This is what happened to God. He isn’t dead. He made the world as a beautiful poem and then started to ...
Source: Buckeye Surgeon - February 20, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
105 Regret Quotes to Help You Let Go and Move on With Your Life
Regret can get you stuck in the past.
In a memory that you keep turning and turning in your head. Without being able to move on.
In today’s post I’d like to share the 105 of the most powerful regret quotes. To help you to let go of that dark and heavy cloud hanging over your head.
I hope these timeless thoughts will help you to create a better today and go forward towards a happier, lighter and more successful tomorrow.
And if you want even more timeless wisdom and motivation then check out this post with quotes on inner peace and this one filled with Wednesday motivation quotes.
Helpful Regret Quotes
“One of the gr...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - February 17, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
poem
Op Note XXXIVThe patient was in a perilous state. Critical condition. We had done all that could be done. Maxed out on pressors. Vent settings 100%. It was all up to him now. Everyone seemed to be praying. His mother in the chair to his right, eyes closed, hands clasped, was whispering a prayer. The father prayed with his head bowed. His best friend from childhood was praying. His brother too. The teenage daughter had made her hands into a steeple. A cleaning lady was making the sign of the cross. His wife alternated between weeping and praying, sometimes praying through the weeping. The nurse was m...
Source: Buckeye Surgeon - January 9, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inflammatory cGAS-STING Signaling in Age-Related Endothelial Dysfunction
Chronic, unresolved inflammatory signaling is a feature of aging, the result of lingering senescent cells, debris from stressed cells, and other processes. When persistent over time, inflammatory signaling is highly disruptive to cell and tissue function, altering behavior in ways that contribute to a wide variety of pathologies. In the vasculature, this includes atherosclerosis, calcification, loss of compliance in the vascular smooth muscle responsible for contraction and dilation of blood vessels, and a range of more subtle problems, lumped under the heading of endothelial dysfunction, at the inner surface of blood vess...
Source: Fight Aging! - December 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
YAP and TAZ in Cell Structure and Cell Senescence
This scientific commentary describes an interesting join the dots exercise in which scientists link together a number of different topics that have shown up over the years in research into aging. Here, the Hippo pathway (activated by YAP and TAZ), the shape and maintenance of the nuclear envelope, inflammatory cGAS/STING signaling, and cellular senescence are all connected. Declining expression of YAP and TAZ occur with aging, for reasons to be explored, and that decline appears sufficient in and of itself to trigger the rest of the linked cascade of changes and consequent cellular senescence and tissue dysfunction.
...
Source: Fight Aging! - November 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Understanding The SAMPLE History
The SAMPLE history usually comes up in the first few weeks of EMT class. It’s such a widely accepted standard that it appears in the National Registry medical and trauma skills station as well as the EMT National Standard Curriculum. As far as subjective patient history’s go…SAMPLE is the gold standard.
Like anything else in medicine, widespread utilization also comes with widespread misunderstanding. The SAMPLE history is an educational gold standard for a reason. It’s a very effective tool for remembering the major components of a medical history. It’s also often misused and highly inadequate when taug...
Source: The EMT Spot - November 2, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
