The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: Am J Physiol Cell Ph... - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: American Journal of Physiology. Cell Physiology - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: Am J Physiol Cell Ph... - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: American Journal of Physiology. Cell Physiology - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: Am J Physiol Cell Ph... - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
The GLP-1-mediated Gut-Kidney Cross Talk in Humans: Mechanistic Insight
Am J Physiol Cell Physiol. 2023 Dec 18. doi: 10.1152/ajpcell.00476.2023. Online ahead of print.ABSTRACTIncretin-based therapy is an anti-diabetic and anti-obesity approach mimicking glucagon-like peptide 1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies on renal effect of GLP-1. There is not consensus about the localization of GLP-1 receptors (GLP-1R) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of ...
Source: American Journal of Physiology. Cell Physiology - December 18, 2023 Category: Cytology Authors: Gitte Rye Hinrichs Peter Hovind Ali Asmar Source Type: research
Incretin-FGF21 fusion molecule maximizes metabolic effects in mice
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 14. doi: 10.3724/abbs.2023276. Online ahead of print.NO ABSTRACTPMID:38098359 | DOI:10.3724/abbs.2023276 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Yulin Kong Shenglong Zhu Yong Q Chen Source Type: research
Incretin-FGF21 fusion molecule maximizes metabolic effects in mice
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 14. doi: 10.3724/abbs.2023276. Online ahead of print.NO ABSTRACTPMID:38098359 | DOI:10.3724/abbs.2023276 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Yulin Kong Shenglong Zhu Yong Q Chen Source Type: research
Incretin-FGF21 fusion molecule maximizes metabolic effects in mice
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 14. doi: 10.3724/abbs.2023276. Online ahead of print.NO ABSTRACTPMID:38098359 | DOI:10.3724/abbs.2023276 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Yulin Kong Shenglong Zhu Yong Q Chen Source Type: research
Altered glucagon and GLP-1 responses to oral glucose in children and adolescents with obesity and insulin resistance
CONCLUSIONS: The OIR-group had elevated fasting concentrations of glucagon and GLP-1, and higher glucagon, but lower GLP-1 responses during an OGTT compared to the OIS- and NW-groups. In contrast, the OIS-group had similar hormone responses to the NW-group.PMID:38087928 | DOI:10.1210/clinem/dgad728 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 13, 2023 Category: Endocrinology Authors: Sara Elizabeth Stinson Ierai Fern ández de Retana Alzola Emilie Damgaard Br ünner Hovendal Morten Asp Vonsild Lund Cilius Esmann Fonvig Louise Aas Holm Anna Elisabet Jonsson Christine Frithioff-B øjsøe Michael Christiansen Oluf Pedersen Lars Ängquist Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: Am J Physiol Endocri... - December 13, 2023 Category: Endocrinology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
Altered glucagon and GLP-1 responses to oral glucose in children and adolescents with obesity and insulin resistance
CONCLUSIONS: The OIR-group had elevated fasting concentrations of glucagon and GLP-1, and higher glucagon, but lower GLP-1 responses during an OGTT compared to the OIS- and NW-groups. In contrast, the OIS-group had similar hormone responses to the NW-group.PMID:38087928 | DOI:10.1210/clinem/dgad728 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 13, 2023 Category: Endocrinology Authors: Sara Elizabeth Stinson Ierai Fern ández de Retana Alzola Emilie Damgaard Br ünner Hovendal Morten Asp Vonsild Lund Cilius Esmann Fonvig Louise Aas Holm Anna Elisabet Jonsson Christine Frithioff-B øjsøe Michael Christiansen Oluf Pedersen Lars Ängquist Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: Am J Physiol Endocri... - December 13, 2023 Category: Endocrinology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
