The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: Am J Physiol Endocri... - March 13, 2024 Category: Endocrinology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Incretin and Glucagon Receptor Polypharmacology in Chronic Kidney Disease
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00374.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes (T2D) and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits. Both GLP-1 and gluc...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Brandon E McFarlin Kevin L Duffin Anish Konkar Source Type: research
The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Incretin and Glucagon Receptor Polypharmacology in Chronic Kidney Disease
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00374.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes (T2D) and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits. Both GLP-1 and gluc...
Source: Am J Physiol Endocri... - March 13, 2024 Category: Endocrinology Authors: Brandon E McFarlin Kevin L Duffin Anish Konkar Source Type: research
The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: Am J Physiol Endocri... - March 13, 2024 Category: Endocrinology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Incretin and Glucagon Receptor Polypharmacology in Chronic Kidney Disease
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00374.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes (T2D) and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits. Both GLP-1 and gluc...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Brandon E McFarlin Kevin L Duffin Anish Konkar Source Type: research
The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Incretin and Glucagon Receptor Polypharmacology in Chronic Kidney Disease
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00374.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes (T2D) and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits. Both GLP-1 and gluc...
Source: Am J Physiol Endocri... - March 13, 2024 Category: Endocrinology Authors: Brandon E McFarlin Kevin L Duffin Anish Konkar Source Type: research
The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: Am J Physiol Endocri... - March 13, 2024 Category: Endocrinology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Incretin and Glucagon Receptor Polypharmacology in Chronic Kidney Disease
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00374.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes (T2D) and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits. Both GLP-1 and gluc...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Brandon E McFarlin Kevin L Duffin Anish Konkar Source Type: research
The Prostaglandin E < sub > 2 < /sub > EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity
Am J Physiol Endocrinol Metab. 2024 Mar 13. doi: 10.1152/ajpendo.00061.2023. Online ahead of print.ABSTRACTSignaling through Prostaglandin E2 EP3 receptor (EP3) actively contributes to the β-cell dysfunction of type 2 diabetes (T2D). In T2D models, full-body EP3 knockout mice have a significantly worse metabolic phenotype than wild-type controls due to hyperphagia and severe insulin resistance resulting from loss of EP3 in extra-pancreatic tissues, masking any potential beneficial effects of EP3 loss in the β-cell. We hypothesized β-cell-specific EP3 knockout (EP3 βKO) mice would be protected from high-fat diet (HFD)-i...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 13, 2024 Category: Physiology Authors: Joshua C Neuman Austin Reuter Kathryn A Carbajal Michael D Schaid Grant Kelly Kelsey Connors Cecilia Kaiser Joshua Krause Liam D Hurley Angela Olvera Dawn Belt Davis Jaclyn A Wisinski Maureen Gannon Michelle E Kimple Source Type: research
Renal effects of GLP-1 receptor agonists and tirzepatide in individuals with type 2 diabetes: seeds of a promising future
ConclusionTirzepatide is likely to counteract most of the pathogenetic factors contributing to CKD in T2D, potentially representing a step forward in incretin-based therapy towards nephroprotection. Further evidence is needed to understand its role in renal hemodynamics, fibrosis, cell damage and atherosclerosis, as well as to conclusively show reduction of hard renal outcomes. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Tirzepatide, a dual incretin analog, is a boon in metabolic syndrome: an editorial
Ann Med Surg (Lond). 2024 Feb 5;86(3):1249-1250. doi: 10.1097/MS9.0000000000001782. eCollection 2024 Mar.NO ABSTRACTPMID:38463093 | PMC:PMC10923294 | DOI:10.1097/MS9.0000000000001782 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Mainak Bardhan Pooja Gokhale Priyanka Roy Tithishri Kundu Ayush Anand Source Type: research
