Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Her work paved the way for blockbuster obesity drugs. Now, she ’s fighting for recognition
When Svetlana Mojsov heard the spring 2021 announcement, she was startled. The Canada Gairdner International Award, a prestigious biomedical research prize, would be bestowed on three scientists for work underpinning the diabetes and obesity drugs that have exploded in popularity in recent years. “I was really upset,” recalls Mojsov, a chemist at Rockefeller University.
The Gairdner award marked the third time in 4 years that the same trio of scientists—Joel Habener at Massachusetts General Hospital (MGH), Daniel Drucker at the University of Toronto, and Jens Juul Holst at the University of Copenhagen—were ho...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research
Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP ‐1
AbstractThe TIGG model is the first model to integrate glucose and insulin regulation, incretin effect, and triglyceride (TG) response in the lipoprotein subclasses of chylomicrons and VLDL-V6. This model described the response following a high-fat meal in individuals who are lean, obese, and very obese and provided insights into the possible regulation of glucose homeostasis in the extended period following a meal. Often, total TGs are analyzed within clinical studies, instead of lipoprotein subclasses. We extended the existing TIGG model to capture the observed total TGs and determined if this model could be used to pred...
Source: CPT: Pharmacometrics and Systems Pharmacology - September 5, 2023 Category: Drugs & Pharmacology Authors: Jennifer Leohr,
Maria C. Kjellsson Tags: ARTICLE Source Type: research
The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease
AbstractIn the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed current guidelines and improved outcomes for individuals with type 2 diabetes. However, the dual glucose-dependent insulinotropic polypeptide receptor (GIPR)/GLP-1R agonist, tirzepatide, has demonstrated superior efficacy regarding improvements in HbA1c and body weight in people with type 2 diabetes. This has led to increasing scientific interest in incretin hormones and incretin interactions, and several compounds based on dual- and multi-agonists are now being investigated for the treatment of metabolic diseases. Herein, we h...
Source: Diabetologia - September 3, 2023 Category: Endocrinology Source Type: research
