Hypertrichosis associated with genetic conditions with head and neck changes
Evaluate the presence of congenital hypertrichosis associated with genetic syndromes and conditions that affect the head and neck. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 17, 2022 Category: ENT & OMF Authors: Mirelle Est éfane De Oliveira Caixeta, Caroline Rodrigues Dias, Laura Cesário Oliveira, Daniella Cristina Borges, Thiago De Amorim Carvalho, Ivania Aparecida Pimenta Santos Silva, Rodrigo Soares De Andrade Source Type: research
Hypertrichosis associated with syndromes with neurological involvement and craniofacial changes
To investigate the correlation of hypertrichosis in syndromes with craniofacial changes and neurological involvement. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 17, 2022 Category: ENT & OMF Authors: Caroline Rodrigues Dias, Mirelle Est éfane De Oliveira Caixeta, Thiago De Amorim Carvalho, Leonardo Biscaro Pereira, Daniella Cristina Borges, Ivania Aparecida Pimenta Santos Silva, Rodrigo Soares De Andrade Source Type: research
Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia
J Dermatolog Treat. 2022 Aug 3:1-60. doi: 10.1080/09546634.2022.2109567. Online ahead of print.ABSTRACTBackground Androgenetic alopecia (AGA) is the most common cause of hair loss, often challenging to treat. While oral finasteride (1 mg/day) is an FDA-approved treatment for male AGA, oral minoxidil and oral dutasteride are not approved yet. However, clinicians have been increasingly using these two drugs off-label for hair loss. Recently, Japan and South Korea have approved oral dutasteride (0.5 mg/day) for male AGA.Efficacy and safety A probable efficacy ranking, in decreasing order, is- dutasteride 0.5 mg/day, finasteri...
Source: Journal of Dermatological Treatment - August 3, 2022 Category: Dermatology Authors: A K Gupta M Talukder G Williams Source Type: research
739 Niche adipocytes activate hair follicle stem cells through metabolic priming
The ability to sense and to respond to the external environment capacitates tissue stem cells to tailor their activity to meet organismal needs. It has long been observed in human that external irritation leads to acquired hypertrichosis, but the mechanism remains unclear. We found that, in mice, hair follicle stem cells (HFSCs) are activated by external irritation with prominent hair regeneration. The external irritation is not directly sensed by HFSCs themselves but by niche adipocytes which undergo lipolysis to activate HFSCs. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: K. Tai, C. Chen, S. Fan, T. Chang, M. Plikus, S. Lin Source Type: research
Unusual facial lesions in H syndrome
We describe a new facial phenotype with dermoscopic and histological features in the spectrum of non-Langerhans cell histiocytosis. (Source: Clinical Case Reports)
Source: Clinical Case Reports - July 18, 2022 Category: General Medicine Authors: Mariem Rekik,
Emna Bahloul,
Mohamed Ben Rejeb,
Khadija Sellami,
Slim Charfi,
Hamza Chouk,
Tahya Boudaouara,
Hamida Turki Tags: CASE REPORT Source Type: research
There Is a Positive Dose-Dependent Association between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings from a Systematic Review with Meta-Regression Analyses
Conclusions: Our study produced new evidence as our work is the first to show a positive dose-dependent association between the use of LDOM and change in hair diameter, hair density, risk of hypertrichosis, and cardiovascular adverse events for persons with AGA. Future randomized trials could produce causal evidence that would corroborate these dose-dependent associations.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - June 30, 2022 Category: Dermatology Source Type: research
Metreleptin Treatment in a Boy with Congenital Generalized Lipodystrophy due to Homozygous c.465_468delGACT (p.T156Rfs*8) Mutation in the < em > BSCL2 < /em > Gene; The First-year Results
J Clin Res Pediatr Endocrinol. 2022 Jun 23. doi: 10.4274/jcrpe.galenos.2022.2022-1-25. Online ahead of print.ABSTRACTCongenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by an almost complete absence of body fat. In CGL, patients may have hyperphagia due to leptin deficiency. Recombinant human leptin (metreleptin) has been suggested as an effective treatment option. We, herein, present the successful use of metreleptin in a case with CGL and its 1-year follow-up. An eight-month-old boy presented with complaints of hair growth and muscular appearance: He had, hypertrichosis, decrea...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 23, 2022 Category: Endocrinology Authors: Şervan Özalkak Meliha Demiral Edip Ünal Funda Feryal Ta ş H üseyin Onay H üseyin Demirbilek Mehmet Nuri Özbek Source Type: research
Safety and efficacy of low-dose diazoxide in small-for-gestational-age infants with hyperinsulinaemic hypoglycaemia
Conclusion
Our study demonstrates that low-dose DZX effectively treats SGA infants with HH as measured by fasting studies. Although the safety profile was excellent, minimal adverse events were still observed with DZX, even at low doses. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Chandran, S., R, P. R., Mei Chien, C., Saffari, S. E., Rajadurai, V. S., Yap, F. Tags: Original research Source Type: research
Hypertrichosis associated with genetic conditions with head and neck alterations
CONCLUSION: The association of hypertrichosis with genetic components is strongly associated with major craniofacial changes. Therefore, the knowledge of the dental surgeon about the conditions that can affect the oral cavity is impressive because it is related to a correct treatment and better quality of life for the patient. (Source: Dentistry 3000)
Source: Dentistry 3000 - June 14, 2022 Category: Dentistry Source Type: research
Genes, Vol. 13, Pages 889: Complex Presentation of Hao-Fountain Syndrome Solved by Exome Sequencing Highlighting Co-Occurring Genomic Variants
Conclusions: The co-occurring variants in USP7 and CFTR variants explained the multisystem disorder of the patient. The comprehensive dissection of the phenotype and early diagnosis of autosomal dominant polycystic kidney disease allowed us to manage the CFTR-related disorder symptoms and monitor renal function and other complications associated with PKD2 haploinsufficiency, addressing proper care and surveillance. (Source: Genes)
Source: Genes - May 16, 2022 Category: Genetics & Stem Cells Authors: Priolo Mancini Pizzi Chiriatti Radio Cordeddu Pintomalli Mamm ì Dallapiccola Tartaglia Tags: Article Source Type: research
