Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome
We report de novo missense variants in KCNN3 in three individuals with typical clinical features of ZLS. KCNN3 (SK3/KCa2.3) constitutes one of three members of the small-conductance Ca2+-activated K+ (SK) channels that are part of a multiprotein complex consisting of the pore-forming channel subunits, the constitutively bound Ca2+ sensor calmodulin, protein kinase CK2, and protein phosphatase 2A. (Source: The American Journal of Human Genetics)
Source: The American Journal of Human Genetics - May 30, 2019 Category: Genetics & Stem Cells Authors: Christiane K. Bauer, Pauline E. Schneeberger, Fanny Kort üm, Janine Altmüller, Fernando Santos-Simarro, Laura Baker, Jennifer Keller-Ramey, Susan M. White, Philippe M. Campeau, Karen W. Gripp, Kerstin Kutsche Tags: Article Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Indurated dusky red swelling on the forearm of an infant: Tufted angioma
We present a case of 8-months-old infant with TA over the right forearm with classical clinical, histoptahological and immunohistochemistry features. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 14, 2019 Category: Dermatology Authors: Deepak Jakhar Archana Singal Ishmeet kaur Priya Pathak Source Type: research

Lasers for Becker ’s nevus
AbstractBecker ’s nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker’s nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. To summarize the clini cal outcomes of Becker’s nevus treated with lasers via literature review. A variety of lasers had been used alone or in combination to treat Becker’s nevus. Laser wavelengths used for Becker’s nevus ranged from 504 to 10,600 nm, while the number of treatment varied from 1 to 12 sess...
Source: Lasers in Medical Science - February 14, 2019 Category: Laser Surgery Source Type: research

Prostaglandin Levels in the Tears of Patients with Mucous Membrane Pemphigoid
Mucous Membrane Pemphigoid is a rare and debilitating disease that affects bodily mucous membranes, especially those of the eyes and oropharynx. It results in ocular surface disease leading to scarring, lid abnormalities and vision loss. Hypertrichosis associated with increased local prostaglandin levels due to topical medication or other types of ocular inflammation has been well documented. We hypothesize that mucous membrane pemphigoid also increases local prostaglandin levels and this increased concentration of prostaglandin contributes to an enhanced lash growth rate. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Fadi Alkhatib, Johnny Nguyn Source Type: research

Clinical, Histochemical, and Molecular Study of Three Turkish Siblings Diagnosed with H Syndrome, and Literature Review
Conclusion: This study not only extended the clinical and mutation spectrum ofSLC29A3 in H syndrome, but also showed that short children should be assessed according to the guidelines for short stature in children.Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - January 13, 2019 Category: Endocrinology Source Type: research

Acquired Localized Hypertrichosis Following Pressure Garment and/or Silicone Therapy in Burn Patients
We report on 7 burn patients who developed hypertrichosis following application of pressure garment/silicone therapy to prevent hypertrophic scarring. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - January 12, 2019 Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

Periocular Manifestations of Afatinib Therapy
Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. She has a 4-year history of spinal chordoma treated with daily Afatinib 50 mg over the past 6 months. Clinical examination revealed trichomegaly and trichiasis affecting all 4 eyelid...
Source: Ophthalmic Plastic and Reconstructive Surgery - January 1, 2019 Category: Opthalmology Tags: Case Reports Source Type: research

Acquired hypertrichosis localized on a subsiding psoriatic plaque after plaster application
We describe the case of a patient who simultaneously developed a single psoriatic plaque and overlying localized hypertrichosis after plaster application. This concurrence is exceptional and may be explained by the expression of several growth factors and cytokines influencing both the hair cycle and the psoriatic inflammatory working. (Source: International Journal of Trichology)
Source: International Journal of Trichology - December 3, 2018 Category: Dermatology Authors: Ambra Di Altobr Annalisa Patrizi Massimiliano Pazzaglia Source Type: research

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum
In conclusion, men can develop scrotal changes due to either intrinsic (aging) or extrinsic (trauma) causes, but nonsurgical interventions and surgical procedures are available for the management of these conditions in individuals who desire to rejuvenate their scrotum. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 26, 2018 Category: Dermatology Source Type: research

Multidisciplinary eyelid reconstruction in Barber-Say syndrome: A case report.
Authors: Barreiro-González A, Barranco-González H, Aviñó-Martínez J, López Blanco E, Gutiérrez Ontalvilla P, Évole-Buselli M Abstract Barber-Say syndrome is an unusual dysplasia caused by the mutation of the TWIST2 gene (2q37.3), which encodes a protein that acts at an epigenetic level. The case is presented of a 2-day-old male child in whom ectropion, hypertelorism, hypertrichosis and other dysmorphic features led to the clinical diagnosis of Barber-Say syndrome, which was later confirmed with genetic tests. Around 20 cases have been reported on this syndrome...
Source: Archivos de la Sociedad Espanola de Oftalmologia - November 22, 2018 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients
AbstractBackgroundSkin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in.Methods177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases.ResultsThe mean age of OTR was 52  years, the mean age at transplantation was 42.7 years, and kidney was the most common organ transplanted (72%). Skin lesions were found in 147 patients (83%). Cutaneous infections were seen in 106 patients (60%). Warts (30%) had the larger incidence and were associated with azathi...
Source: International Journal of Dermatology - November 22, 2018 Category: Dermatology Authors: Walmar R. P. Oliveira, Maria C. C. P. Tirico, Anaisa A. V. Souza, Felipe R. Codarin, Lana L. C. Silva, Cyro Festa Neto Tags: Report Source Type: research

Progressive discoloration over the right shoulder.
Abstract The discolored patch on our patient's shoulder was nothing new-but when it grew in size and developed hypertrichosis, it prompted a closer investigation. PMID: 30481248 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - November 1, 2018 Category: Practice Management Authors: Helm MF, Cole D, Seiverling EV Tags: J Fam Pract Source Type: research

Genital Rejuvenation: The Next Frontier in Medical and Cosmetic Dermatology
Genital rejuvenation encompasses not only the nonsurgical interventions but also the surgical procedures that are utilized to improve the functional aspects and/or enhance the aesthetic presentation of the genitalia of women (vaginal rejuvenation) and men (scrotal rejuvenation). Vaginal rejuvenation was introduced into the medical literature in 2007; yet, within the last decade, physician and patient interest in this field has markedly increased. In contrast, the term scrotal rejuvenation was only coined in 2018. Rejuvenation of the genitalia may be considered for hair-associated (alopecia and hypertrichosis), morphology-a...
Source: Dermatology Online Journal - October 24, 2018 Category: Dermatology Source Type: research

Orthognathic Surgical Correction in Patients with Cantu Syndrome: Medical Considerations
Cantu Syndrome (CS) is a rare autosomal dominant disorder in the ABCC9 or KCNJ8 gene characterized by congenital generalized hypertrichosis, coarse facial features (broad nasal bridge, epicanthal folds, wide mouth, macroglossia), skeletal abnormalities (calvarial thickening, metaphyseal flares, coxa valga, scoliosis), and cardiac issues (patent ductus arteriosis (PDA), pericardial effusion). Despite commonly described craniofacial differences, there are currently no documented cases of a patient with CS having orthognathic surgery in the literature. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 1, 2018 Category: ENT & OMF Authors: C. Kurian, M.A. Lypka Tags: Poster Session: Pediatrics Source Type: research

Genital Rejuvenation: The Next Frontier in Medical and Cosmetic Dermatology.
Abstract Genital rejuvenation encompasses not only the nonsurgical interventions but also the surgical procedures that are utilized to improve the functional aspects and/or enhance the aesthetic presentation of the genitalia of women (vaginal rejuvenation) and men (scrotal rejuvenation). Vaginal rejuvenation was introduced into the medical literature in 2007; yet, within the last decade, physician and patient interest in this field has markedly increased. In contrast, the term scrotal rejuvenation was only coined in 2018. Rejuvenation of the genitalia may be considered for hair-associated (alopecia and hypertricho...
Source: Dermatol Online J - September 15, 2018 Category: Dermatology Authors: Cohen PR Tags: Dermatol Online J Source Type: research

RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann –Steiner Syndrome
AbstractA growing number of histone modifiers are involved in human neurodevelopmental disorders, suggesting that proper regulation of chromatin state is essential for the development of the central nervous system. Among them, heterozygous de novo variants inKMT2A, a gene coding for histone methyltransferase, have been associated with Wiedemann –Steiner syndrome (WSS), a rare developmental disorder mainly characterized by intellectual disability (ID) and hypertrichosis. As KMT2A is known to regulate the expression of multiple target genes through methylation of lysine 4 of histone 3 (H3K4me), we sought to investigate...
Source: NeuroMolecular Medicine - September 1, 2018 Category: Neurology Source Type: research

Angiosarcoma associated with hypertrichosis
(Source: European Journal of Dermatology)
Source: European Journal of Dermatology - September 1, 2018 Category: Dermatology Source Type: research

Giant fibrous hamartoma of infancy: pitfall of CD34 positive dermal mesenchymal tumor
Fibrous hamartoma of infancy (FHI) is a rare benign soft tissue tumor with a triphasic organoid histologic appearance. The authors present a case of a 21-month-old healthy girl with a slowly growing flesh-colored subcutaneous plaque 12cm in size on the lower back, with overlying hypertrichosis. A punch biopsy revealed a proliferation of spindle cells infiltrating the dermis and hypodermis organized in a dense storiform pattern with a strong diffuse positivity for CD34. The diagnosis of congenital dermatofibrosarcoma protuberans (DFSP) was considered and an excision was performed. Histopathologic analysis showed an extensiv...
Source: Dermatology Online Journal - August 22, 2018 Category: Dermatology Source Type: research

Transient hypertrichosis with temporary tattooing in two siblings
Publication date: Available online 16 August 2018Source: Dermatologica SinicaAuthor(s): Hülya Nazik, Feride Çoban Gül, Mehmet Kamil Mülayim, Perihan Öztürk, Serkan KirikAbstractTemporary tattooing with black henna is becoming increasingly popular among children and young adults. Complications are seen depending on additives added to henna for different purposes. Two sisters, aged 8 and 11, had a temporary tattoo. The tattoos began to disappear after 2 weeks. At the end of a month, pigmentation completely disappeared and hypertrichosis was observed on the site of the tattoo figures. There wer...
Source: Dermatologica Sinica - August 16, 2018 Category: Dermatology Source Type: research

Plexiform Schwannoma with Localized Hypertrichosis.
Authors: Kim WI, Kim TW, Park SM, Lee HJ, Jin H, You HS, Shim WH, Kim GW, Kim HS, Kim BS, Kim MB, Ko HC PMID: 30065605 [PubMed] (Source: Annals of Dermatology)
Source: Annals of Dermatology - August 5, 2018 Category: Dermatology Tags: Ann Dermatol Source Type: research

What can hide a faun tail?
Introduction: Faun tail is a well defined area of congenital hypertrichosis, typically of triangular morphology, situated in the central lumbosacral region. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Faun tail nevus: A series of 15 cases and their management with Intense Pulse Light
ConclusionThis article aims to present a series of this rare neurocutaneous marker and highlight our experience in their management with IPL served as an effective alternative to traditional lasers. (Source: Medical Journal Armed Forces India)
Source: Medical Journal Armed Forces India - August 2, 2018 Category: General Medicine Source Type: research

RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann –Steiner Syndrome
AbstractA growing number of histone modifiers are involved in human neurodevelopmental disorders, suggesting that proper regulation of chromatin state is essential for the development of the central nervous system. Among them, heterozygous de novo variants inKMT2A, a gene coding for histone methyltransferase, have been associated with Wiedemann –Steiner syndrome (WSS), a rare developmental disorder mainly characterized by intellectual disability (ID) and hypertrichosis. As KMT2A is known to regulate the expression of multiple target genes through methylation of lysine 4 of histone 3 (H3K4me), we sought to investigate...
Source: NeuroMolecular Medicine - July 16, 2018 Category: Neurology Source Type: research

Peculiar hypertrichosis in a patient affected by Frontal fibrosing alopecia with pseudo "fringe sign".
Peculiar hypertrichosis in a patient affected by Frontal fibrosing alopecia with pseudo "fringe sign". G Ital Dermatol Venereol. 2018 Jun 29;: Authors: Grassi S, Carlesimo M, Fortuna MC, Rossi A PMID: 29963802 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Source: Giornale Italiano di Dermatologia e Venereologia - July 3, 2018 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Localized hypertrichosis at vaccination site
Kavita Poonia, Pragati Gogia, Mala BhallaInternational Journal of Trichology 2018 10(3):138-139 Hypertrichosis is described as an increased hair growth on any part or over whole body in comparison to persons of the same age, sex, and race which is independent of androgen excess. It may be localized and generalized or alternatively acquired and congenital forms. The acquired localized hypertrichosis has been associated with various causes including local trauma, chronic irritation, inflammation, occlusion by cast, and drugs. Here, we report a case of 2½-month-old healthy infant presenting with localized area of hypert...
Source: International Journal of Trichology - June 20, 2018 Category: Dermatology Authors: Kavita Poonia Pragati Gogia Mala Bhalla Source Type: research

GSE115969 RNA sequencing and pathway analysis identify important pathways involved in hypertrichosis and intellectual disability in patients with Wiedemann-Steiner syndrome
Contributors : L éo Mietton ; Nicolas Lebrun ; Irina Giurgea ; Alice Goldenberg ; Benjamin Saintpierre ; Juliette Hamroune ; Alexandra Afenjar ; Pierre Billuart ; Thierry BienvenuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq in Wiedemann Steiner syndrome (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 19, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Giant fibrous hamartoma of infancy: pitfall of CD34 positive dermal mesenchymal tumor.
This article highlights the importance of being aware of the CD34+ dermal mesenchymal tumor differential diagnosis and the necessity of appropriate size biopsies to avoid sampling error. PMID: 30142714 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - June 15, 2018 Category: Dermatology Authors: Miroux-Catarino A, Claro C, Viana I Tags: Dermatol Online J Source Type: research

Novel mutation in ABBC9 gene associated with congenital hypertrichosis and acromegaloid facial features, without cardiac or skeletal anomalies: a new phenotype [Corrigendum]
(Source: Application of Clinical Genetics)
Source: Application of Clinical Genetics - May 31, 2018 Category: Genetics & Stem Cells Tags: The Application of Clinical Genetics Source Type: research

GSE109632 Expression data from human hair follicles (ex vivo) incubated with cyclosporine A and vehicle control
Series Type : Expression profiling by arrayOrganism : Homo sapiensSince hair growth disorders can carry a major psychological burden, more effective human hair growth-modulatory agents need to be urgently developed. Here, we used the hypertrichosis-inducing immunosuppressant, cyclosporine A (CsA), as a lead compound to identify new hair growth-promoting targets. Through microarray analysis we identified the Wnt inhibitor, SFRP1, as being downregulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo. Therefore, we further investigated the function of SFRP1 using a pharmacological approach ...
Source: GEO: Gene Expression Omnibus - May 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
by Nathan J. Hawkshaw, Jonathan A. Hardman, Iain S. Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth–modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth–promoti ng molecular targets. Through microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair...
Source: PLoS Biology: Archived Table of Contents - May 8, 2018 Category: Biology Authors: Nathan J. Hawkshaw Source Type: research

748 Segmental odonto-maxillary dysplasia is caused by mosaic variants in the gene encoding beta-actin
Segmental odontomaxillary dysplasia (SOD) is a rare sporadic disorder of unknown aetiology affecting the face, presenting at birth or in early childhood. Affected individuals can have progressive hypertrichosis, increased or decreased pigmentation, erythema, asymmetry, dental anomalies and commissural lip fissures. Here we present detailed phenotypic, histological and radiological data from a cohort of eight patients, and investigate the genetic basis of the disorder. We hypothesised that this condition could be due to a post-zygotic mutation in utero. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: S. Polubothu, A. Thomas, A. Calder, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis?
Unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress. Therefore, new pharmacological treatment strategies that safely and effectively inhibit hair growth while preserving the hair follicle (HF) stem cells pool need to be developed. Since human HFs express the immunomodulatory glycoprotein, osteopontin, we hypothesized that osteopontin-derived fragments may modulate human hair growth. This hypothesis was tested ex vivo and in vivo by using a newly generated, toxicologically well-characterized, modified osteopontin-derived peptide (FOL-005), which binds to the HFs outer root sheath. (Source...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: M. Bertolini, M. Alam, J. Gherardini, A. Keren, L. Ponce, J. Alenfall, P. Dun ér, A. Nilsson, A. Gilhar, R. Paus Tags: Skin, Appendages, and Stem Cell Biology Source Type: research

Extending the clinical and genetic spectrum of ARID2 related intellectual disability. A case series of 7 patients.
Abstract In the last 3 years de novo sequence variants in the ARID2 (AT-rich interaction domain 2) gene, a subunit of the SWI/SNF complex, have been linked to intellectual disabilities in 3 case reports including one which describes frameshift mutations in ARID2 in 2 patients with features resembling Coffin-Siris syndrome. Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by intellectual deficit, coarse facial features and hypoplastic or absent fifth fingernails and/or toenails among other features. Mutations in a number of different genes encoding SWI/SNF chromatin remodelling complex protei...
Source: European Journal of Medical Genetics - April 23, 2018 Category: Genetics & Stem Cells Authors: Gazdagh G, Blyth M, Scurr I, Turnpenny PD, Mehta SG, Armstrong R, McEntagart M, Newbury-Ecob R, Tobias ES, DDD Study, Joss S Tags: Eur J Med Genet Source Type: research

748 Segmental odonto-maxillary dysplasia is caused by mosaic variants in the gene encoding beta-actin
Segmental odontomaxillary dysplasia (SOD) is a rare sporadic disorder of unknown aetiology affecting the face, presenting at birth or in early childhood. Affected individuals can have progressive hypertrichosis, increased or decreased pigmentation, erythema, asymmetry, dental anomalies and commissural lip fissures. Here we present detailed phenotypic, histological and radiological data from a cohort of eight patients, and investigate the genetic basis of the disorder. We hypothesised that this condition could be due to a post-zygotic mutation in utero. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: S. Polubothu, A. Thomas, A. Calder, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis?
Unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress. Therefore, new pharmacological treatment strategies that safely and effectively inhibit hair growth while preserving the hair follicle (HF) stem cells pool need to be developed. Since human HFs express the immunomodulatory glycoprotein, osteopontin, we hypothesized that osteopontin-derived fragments may modulate human hair growth. This hypothesis was tested ex vivo and in vivo by using a newly generated, toxicologically well-characterized, modified osteopontin-derived peptide (FOL-005), which binds to the HFs outer root sheath. (Source...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: M. Bertolini, M. Alam, J. Gherardini, A. Keren, L. Ponce, J. Alenfall, P. Dun ér, A. Nilsson, A. Gilhar, R. Paus Tags: Skin, Appendages, and Stem Cell Biology Source Type: research

CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery
With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, post-surgery alopecia and localized hypertrichosis, alopecia attributed to therapeutic transplants, and to novel anticancer therapies. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Corina van den Hurk, Shari Goldfarb, Joaquin Jimenez, Anthony M. Rossi, Ralf Paus, Mario E. Lacouture Source Type: research

CME Part 1: Hair disorders in cancer patients
Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color...
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Shari Goldfarb, Julie Nangia, Joaquin J. Jimenez, Ralf Paus, Mario E. Lacouture Source Type: research

CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery
With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, post-surgery alopecia and localized hypertrichosis, alopecia attributed to therapeutic transplants, and to novel anticancer therapies. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Corina van den Hurk, Shari Goldfarb, Joaquin Jimenez, Anthony M. Rossi, Ralf Paus, Mario E. Lacouture Source Type: research

CME Part 1: Hair disorders in cancer patients
Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color...
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Shari Goldfarb, Julie Nangia, Joaquin J. Jimenez, Ralf Paus, Mario E. Lacouture Source Type: research

Hair disorders in cancer survivors
With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy –induced alopecia and hirsutism, postsurgery alopecia and localized hypertrichosis, and persistent stem cell transplantation and targeted therapy-induced alopecia. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Corina van den Hurk, Shari Goldfarb, Joaquin J. Jimenez, Anthony M. Rossi, Ralf Paus, Mario E. Lacouture Tags: Continuing medical education Source Type: research

Hair disorders in patients with cancer
Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders, including alopecia, hirsutism, hypertrichosis, and pigmentary and textural hair changes. The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy-induced alopecia has been well documented primarily in the oncology literature; however, the effect of other alterations, such as radiation-induced alopecia, hirsutism, and changes in...
Source: Journal of the American Academy of Dermatology - April 13, 2018 Category: Dermatology Authors: Azael Freites-Martinez, Jerry Shapiro, Shari Goldfarb, Julie Nangia, Joaquin J. Jimenez, Ralf Paus, Mario E. Lacouture Tags: Continuing medical education Source Type: research

Omeprazole ‐induced hypertrichosis in two children
Pediatric Dermatology, EarlyView. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - March 26, 2018 Category: Dermatology Source Type: research

Localized hypertrichosis of intermammary cleft in monozygotic twins
Pediatric Dermatology, EarlyView. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - March 24, 2018 Category: Dermatology Source Type: research

Novel mutation in ABBC9 gene associated with congenital hypertrichosis and acromegaloid facial features, without cardiac or skeletal anomalies: a new phenotype
(Source: Application of Clinical Genetics)
Source: Application of Clinical Genetics - March 23, 2018 Category: Genetics & Stem Cells Tags: The Application of Clinical Genetics Source Type: research

Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors
Publication date: Available online 8 March 2018 Source:The Veterinary Journal Author(s): Joanne L. Ireland, Catherine M. McGowan Pituitary pars intermedia dysfunction (PPID) is caused by an age-related degenerative disease of dopaminergic neurones. Despite its importance in equine practice, available information regarding its epidemiology is limited. This systematic review aimed to assess published literature to evaluate available evidence regarding the clinical presentation, prevalence and risk factors for PPID in horses and ponies. Electronic database searches were undertaken using a range of terms, and English language...
Source: The Veterinary Journal - March 9, 2018 Category: Veterinary Research Source Type: research

[Diffuse hypertrichosis revealing non-classical congenital adrenal hyperplasia].
CONCLUSION: In children presenting NC-CAH, the appearance of pubic hair and hirsutism often constitute the initial reasons for consultation, including with dermatologists. However, hypertrichosis may occur in isolation. It is important that these abnormalities be clearly known to enable early diagnosis and rapid initiation of simple and readily accessible treatment. PMID: 29525066 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 7, 2018 Category: Dermatology Authors: Berthin C, Sibilia P, Martins-Hericher J, Donzeau A, Martin L Tags: Ann Dermatol Venereol Source Type: research

In Vivo Analysis of Prostaglandins-induced Ocular Surface and Periocular Adnexa Modifications in Patients with Glaucoma
Conclusion: PGAs induce several modifications of the OS structures and adnexa; nonetheless, none of them significantly reduces the local safety profile of this class of drugs. Moreover, the OS changes do not affect the IOP lowering efficacy of PGAs. On these bases, local SEs of PGAs should not discourage clinicians in using this class of medications because of their efficacy, the systemic safety profile, and the better adherence. (Source: In Vivo)
Source: In Vivo - February 23, 2018 Category: Research Authors: DI STASO, S., AGNIFILI, L., CECANNECCHIA, S., DI GREGORIO, A., CIANCAGLINI, M. Tags: Reviews Source Type: research

Congenital hypertrichosis lanuginosa
Iffat Hassan Shah, Sumaya Zeerak, Peerzada Sajad, Safia Bashir, Yasmeen J Bhat, Syed MubashirIndian Journal of Dermatology, Venereology, and Leprology 2018 84(2):248-248 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - February 16, 2018 Category: Dermatology Authors: Iffat Hassan Shah Sumaya Zeerak Peerzada Sajad Safia Bashir Yasmeen J Bhat Syed Mubashir Source Type: research