Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity
This study aimed to determine the impact of altered ABCA5 activity on hair follicle keratinocyte behaviour. Primary keratinocytes isolated from the outer root sheath of plucked human hair follicles were utilised as a relevant cell model. Following exogenous cholesterol loading, an increase in ABCA5 co-localisation to intracellular organelles was seen. Knockdown of ABCA5 revealed a dysregulation in cholesterol homeostasis, with LXR agonism leading to partial restoration of the homeostatic response. Filipin staining and live BODIPY cholesterol immunofluorescence microscopy revealed a reduction in endo-lysosomal cholesterol f...
Source: Biochimica et Biophysica Acta - June 22, 2023 Category: Biochemistry Authors: Megan A Palmer Irundika H K Dias Eleanor Smart Yvonne Benatzy Iain S Haslam Source Type: research
Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity
This study aimed to determine the impact of altered ABCA5 activity on hair follicle keratinocyte behaviour. Primary keratinocytes isolated from the outer root sheath of plucked human hair follicles were utilised as a relevant cell model. Following exogenous cholesterol loading, an increase in ABCA5 co-localisation to intracellular organelles was seen. Knockdown of ABCA5 revealed a dysregulation in cholesterol homeostasis, with LXR agonism leading to partial restoration of the homeostatic response. Filipin staining and live BODIPY cholesterol immunofluorescence microscopy revealed a reduction in endo-lysosomal cholesterol f...
Source: Mol Biol Cell - June 22, 2023 Category: Molecular Biology Authors: Megan A Palmer Irundika H K Dias Eleanor Smart Yvonne Benatzy Iain S Haslam Source Type: research
Adverse Events of Light-Assisted Hair Removal: An Updated Review
CONCLUSION: Optical incidents can be systematically avoided. Cutaneous complications are usually related to professional errors and patient characteristics. Better knowledge of laser physics and adequate training of laser operators are key recommendations to avoid undesirable side effects. Safety recommendations help prevent most of the reported complications.PMID:37272371 | DOI:10.1177/12034754231174852 (Source: Herpes)
Source: Herpes - June 5, 2023 Category: Infectious Diseases Authors: Farid Mallat C éline Chaaya Maroun Aoun Boutros Soutou Josiane Helou Source Type: research
Adverse Events of Light-Assisted Hair Removal: An Updated Review
CONCLUSION: Optical incidents can be systematically avoided. Cutaneous complications are usually related to professional errors and patient characteristics. Better knowledge of laser physics and adequate training of laser operators are key recommendations to avoid undesirable side effects. Safety recommendations help prevent most of the reported complications.PMID:37272371 | DOI:10.1177/12034754231174852 (Source: Herpes)
Source: Herpes - June 5, 2023 Category: Infectious Diseases Authors: Farid Mallat C éline Chaaya Maroun Aoun Boutros Soutou Josiane Helou Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
Rheumatoid Arthritis or Imitator?
J Rheumatol. 2023 Jun 1:jrheum.2022-1253. doi: 10.3899/jrheum.2022-1253. Online ahead of print.ABSTRACTH syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. A 37-year-old woman was referred to the rheumatology department with a prediagnosis of rheumatoid arthritis due to deformity in the hands and feet and mild sensorineural hearing loss since the age of 17.PMID:37263650 | DOI:10.3899/jrheum.2022-1253 (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2023 Category: Rheumatology Authors: Fatih Albayrak Emrah Koc Source Type: research
