Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: Am J Physiol Cell Ph... - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: American Journal of Physiology. Cell Physiology - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: American Journal of Physiology. Cell Physiology - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: Am J Physiol Cell Ph... - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: American Journal of Physiology. Cell Physiology - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: Am J Physiol Cell Ph... - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: American Journal of Physiology. Cell Physiology - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats
This study examined the effect of empagliflozin (EMPA) on renal tubular sodium transport in normotensive and spontaneously hypertensive rats (SHRs). It also tested the hypothesis that EMPA-mediated PT NHE3 inhibition in normotensive rats is associated with upregulation of distal nephron apical sodium transporters. EMPA administration for 14 days reduced BP in 12-week-old SHRs but not in age-matched Wistar rats. PT NHE3 activity was inhibited by EMPA treatment in both Wistar and SHRs. In Wistar rats, EMPA increased NCC activity, mRNA expression, protein abundance, and phosphorylation levels, but not in SHRs. SHRs showed hig...
Source: Am J Physiol Cell Ph... - April 1, 2024 Category: Cytology Authors: Paulo C Castro Thiago Matheus Santos-Rios Fl ávia Letícia Martins Renato O Crajoinas Marcos Vin ícius Caetano Luc ília M A Lessa Weverton Machado Luchi James A McCormick Adriana C C Girardi Source Type: research
Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients
In conclusion, the presence of the T allele of the rs4291 variant was associated to controled blood pressure when losartan was used as an antihypertensive agent. These results show the importance of pharmacogenetic studies to detect genetic characteristics, enabling therapeutic individuality and reducing costs for the healthcare system.PMID:38551694 | DOI:10.1007/s11033-024-09437-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: L ívia da Cunha Agostini Wal éria de Paula Andr é Sacramento Melo Nayara Nascimento Toledo Silva Ana Cl áudia Faria Lopes Vanessa de Almeida Belo Wendel Coura-Vital Luiz Fernando de Medeiros Teixeira Ang élica Alves Lima Glenda Nicioli da Silva Source Type: research
Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients
In conclusion, the presence of the T allele of the rs4291 variant was associated to controled blood pressure when losartan was used as an antihypertensive agent. These results show the importance of pharmacogenetic studies to detect genetic characteristics, enabling therapeutic individuality and reducing costs for the healthcare system.PMID:38551694 | DOI:10.1007/s11033-024-09437-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: L ívia da Cunha Agostini Wal éria de Paula Andr é Sacramento Melo Nayara Nascimento Toledo Silva Ana Cl áudia Faria Lopes Vanessa de Almeida Belo Wendel Coura-Vital Luiz Fernando de Medeiros Teixeira Ang élica Alves Lima Glenda Nicioli da Silva Source Type: research
Severe Hypercalcemia Caused by Calcium-Alkali Syndrome after 15 Years of Postoperative Hypoparathyroidism in a Patient with Undiagnosed Hyperaldosteronism
CONCLUSION: Although seldom described, the calcium-alkali syndrome is an expected complication for individuals with postoperative hypoparathyroidism, as they require lifelong calcium and vitamin D supplementation. This case also shows the importance of hydrochlorothiazide use and primary aldosteronism as possible triggers of life-threatening hypercalcemia.PMID:38404648 | PMC:PMC10890900 | DOI:10.1155/2024/3067354 (Source: Cancer Control)
Source: Cancer Control - February 26, 2024 Category: Cancer & Oncology Authors: Nat ália Diel Boufleuer Dimitris V Rados Tatiana Zambonato Clara K Maraschin Beatriz D Schaan Source Type: research
Combined eutexia and amorphization for simultaneous enhancement of dissolution rate of triamterene and hydrochlorothiazide: Preparation of orodispersible tablets
Conclusion: The study introduced simple co-processing with traditional excipients for development of ODT of triamterene and hydrochlorothiazide.PMID:38400841 | DOI:10.1080/03639045.2024.2323996 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 24, 2024 Category: Drugs & Pharmacology Authors: Hend A Awad Mohamed I Fetouh Amal A Sultan Gamal M ElMaghraby Source Type: research
