Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients

In conclusion, the presence of the T allele of the rs4291 variant was associated to controled blood pressure when losartan was used as an antihypertensive agent. These results show the importance of pharmacogenetic studies to detect genetic characteristics, enabling therapeutic individuality and reducing costs for the healthcare system.PMID:38551694 | DOI:10.1007/s11033-024-09437-1

Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: L ívia da Cunha Agostini Wal éria de Paula Andr é Sacramento Melo Nayara Nascimento Toledo Silva Ana Cl áudia Faria Lopes Vanessa de Almeida Belo Wendel Coura-Vital Luiz Fernando de Medeiros Teixeira Ang élica Alves Lima Glenda Nicioli da Silva Source Type: research