A Case of Milk-Alkali Syndrome Caused by Diuretic-Induced Alkalosis and Polypharmacy
We report a case of milk-alkali syndrome caused by loop-diuretic-induced alkaline load and polypharmacy in an 85-year-old Japanese woman with multiple comorbidities, including osteoporosis, hypertension, type 2 diabetes, dyslipidemia, and Parkinson's disease. The patient regularly took 14 drugs, including calcium L-aspartate, eldecalcitol, celecoxib, and a fixed-dose combination of losartan and hydrochlorothiazide. Immediately before admission, furosemide was administered for the treatment of edema. The patient presented with chest discomfort, general malaise, and clinical signs of dehydration, hypercalcemia, hypophosphate...
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Naoya Mizutani Ken Goda Tsuneaki Kenzaka Source Type: research
A Case of Milk-Alkali Syndrome Caused by Diuretic-Induced Alkalosis and Polypharmacy
We report a case of milk-alkali syndrome caused by loop-diuretic-induced alkaline load and polypharmacy in an 85-year-old Japanese woman with multiple comorbidities, including osteoporosis, hypertension, type 2 diabetes, dyslipidemia, and Parkinson's disease. The patient regularly took 14 drugs, including calcium L-aspartate, eldecalcitol, celecoxib, and a fixed-dose combination of losartan and hydrochlorothiazide. Immediately before admission, furosemide was administered for the treatment of edema. The patient presented with chest discomfort, general malaise, and clinical signs of dehydration, hypercalcemia, hypophosphate...
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Naoya Mizutani Ken Goda Tsuneaki Kenzaka Source Type: research
Metal-organic framework based drug delivery systems as smart carriers for release of poorly soluble drugs hydrochlorothiazide and dapsone
Dalton Trans., 2023, Accepted Manuscript DOI: 10.1039/D3DT01301D, PaperPreety Yadav, Priya Bhardwaj, Mulaka Maruthi, Anindita Chakraborty, Prakash Kanoo Drug delivery systems (DDSs) that are derived from biocompatible carriers are attractive platforms for sustained release of drugs. In particular, sustained and controlled release of poorly soluble BCS (Biopharmaceutics Classification... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - July 26, 2023 Category: Chemistry Authors: Preety Yadav Source Type: research
Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial
This study did not support the use of triamterene as an add-on therapy for patients with HF-related diuretic resistance. This article is protected by copyright. All rights reserved.PMID:37493211 | DOI:10.1002/jcph.2321 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - July 26, 2023 Category: Drugs & Pharmacology Authors: Mohammadreza Taban-Sadeghi Elnaz Khani Kimia Khezripour Elgar Enamzadeh Naser Safaei Taher Entezari-Maleki Source Type: research
Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial
This study did not support the use of triamterene as an add-on therapy for patients with HF-related diuretic resistance. This article is protected by copyright. All rights reserved.PMID:37493211 | DOI:10.1002/jcph.2321 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - July 26, 2023 Category: Drugs & Pharmacology Authors: Mohammadreza Taban-Sadeghi Elnaz Khani Kimia Khezripour Elgar Enamzadeh Naser Safaei Taher Entezari-Maleki Source Type: research
Unveiling hydrochlorothiazide: Skin cancer risk and hidden interactions
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 26, 2023 Category: Dermatology Authors: Elisabetta Magnaterra, Martina Lambertini, Federica Scarf ì, Massimo Gola, Emi Dika, Vincenzo De Giorgi Source Type: research
Response to Magnaterra et al. ’s Unveiling hydrochlorothiazide: Skin cancer risk and hidden interactions
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 24, 2023 Category: Dermatology Authors: Laurent Azoulay, Audray St-Jean, Robert W. Platt Source Type: research
Response to Magnaterra et al’s unveiling hydrochlorothiazide: Skin cancer risk and hidden interactions
We thank Dr Magnaterra et al for their interest in our study. It is true that, besides hydrochlorothiazide, there are other photosensitizing drugs than can theoretically increase the risk of skin cancer. They suggest that failure to account for concurrent use of other photosensitizing drugs may introduce confounding, and r aise the possibility of drug-drug interactions further increasing skin cancer risk. Drug-induced photosensitivity reactions have been reported with other thiazide or thiazide-like diuretics and other antihypertensives, including angiotensin-converting enzyme inhibitors and calcium channel blockers . ...
Source: Journal of the American Academy of Dermatology - July 24, 2023 Category: Dermatology Authors: Laurent Azoulay, Audray St-Jean, Robert W. Platt Tags: JAAD Online Source Type: research
The effect of hydrochlorothiazide on the recurrence of nonmelanoma skin cancer: a 7-year retrospective study comprising 300 patients
This study aims to investigate the association between HCTZ use and recurrence in patients with NMSC.METHODS: We identified cases with NMSC from our hospital archives during the period between 2013 and 2019. Patients were divided into groups according to the pathological diagnosis, HCTZ use, and recurrence. Multivariable analysis was performed to determine factors associated with recurrence in BCC and SCC.RESULTS: Recurrences of BCC were significantly higher in HCTZ users with ORs of 4.839221 (95% confidence interval [CI], 1.22-19.12).In HCTZ users, NMSC cases were associated with increased age (p < 0.001 for both BCC a...
Source: Turkish Journal of Medical Sciences - July 21, 2023 Category: General Medicine Authors: Burak Özkan S üleyman Savran Kadri Ak ıncı Abbas Albayati Pinar İncel Uysal Ahmet Çağrı Uysal Source Type: research
