Why I don ’ t trust my clinical reasoning: and why this matters
“See someone experienced” I hear people with pain say. “They’ll know what’s wrong with you.” Well, based on the research I’ve read, I wouldn’t be so sure. In fact, I’m certain my own clinical reasoning is biased, prone to errors that I don’t notice, and influenced by factors that most clinicians would be horrified to think they, too, were influenced by. Let me give you a few to ponder: I’m interested in women and pain – and there’s a lot of evidence showing that women’s pain doesn’t get the same kind of diagnostic and managem...
Source: HealthSkills Weblog - July 11, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Interdisciplinary teams Occupational therapy Pain conditions Physiotherapy Professional topics Psychology Research Science in practice Chronic pain Clinical reasoning healthcare Source Type: blogs

Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future. ...
Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tryptophan and Age-Related Changes in the Gut Microbiome
Researchers here suggest that reduced tryptophan intake can change the balance of populations in the gut microbiome to favor inflammatory microbes. Diet in late life is often deficient, with consequences that can approach outright malnutrition. It seems unlikely that this is a major issue earlier in life, however, and the gut microbiome exhibits harmful shifts in composition as early as the mid-30s. The influence of changes in the gut microbiome on health may be in a similar range to those of exercise, so it is a topic of growing interest in the research community. Ways to preserve or reset the gut microbiome have been dem...
Source: Fight Aging! - July 7, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Rapid Diagnosis of Infectious Disease at Point of Care: Interview with Shawn Marcel, CEO of Torus Biosystems
Torus Biosystems, a medtech startup that spun out of Harvard’s Wyss Institute for Biologically Inspired Engineering, has developed the Synestia system, a point of care diagnostic tool for infectious disease. The system aims to provide rapid, point-of-care identification of pathogens, and incorporates microarray and qPCR technology.    The company reports that the system allows a clinician to run multiple tests on one device to detect all the pathogens associated with a specific disease. The run-time is rapid, with the device providing results in as little as 30 minutes, and for each sample over 1000 targets can ...
Source: Medgadget - June 24, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Exclusive Medicine Public Health torusbiosystems Source Type: blogs

Rapid Diagnosis of Infectious Disease at Point of Care: Interview with Shawn Marcell, CEO of Torus Biosystems
Torus Biosystems, a medtech startup that spun out of Harvard’s Wyss Institute for Biologically Inspired Engineering, has developed the Synestia system, a point of care diagnostic tool for infectious disease. The system aims to provide rapid, point-of-care identification of pathogens, and incorporates microarray and qPCR technology.    The company reports that the system allows a clinician to run multiple tests on one device to detect all the pathogens associated with a specific disease. The run-time is rapid, with the device providing results in as little as 30 minutes, and for each sample over 1000 targ...
Source: Medgadget - June 24, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Exclusive Medicine Public Health torusbiosystems Source Type: blogs

HIV and migration: understanding the barriers faced by people born abroad living with HIV in the UK
This report, based on interviews with migrants living with HIV in the UK, found migrants are being left behind in the UK ’s response to HIV, despite being disproportionately affected by HIV. Respondents said they experienced significant barriers accessing HIV testing, prevention, treatment, and care. It recommends how to improve the health outcomes and quality of life of migrants living with or at risk of HIV in the UK.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - June 22, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Equality and diversity Source Type: blogs

Can the controversial FDA approval of Aduhelm backfire and delay the discovery of actual Alzheimer ’s treatments? (Yes, it can)
This article was originally published on The Conversation. News in Context: US Senator Joe Manchin calls for a new FDA Commissioner to replace current (acting) one who “has repeatedly ignored public health concerns and shown a dereliction of duty” over opioids and aducanumab First, do no harm? Six reasons to approach anti-amyloid drug Aduhelm cautiously, if at all Growing backlash against the FDA approval of unproven Alzheimer’s treatment Aduhelm, by Biogen A critical appraisal of amyloid-B-targeting therapies for Alzheimer disease   The post Can the controversial FDA approval of Aduhelm backfire and...
Source: SharpBrains - June 21, 2021 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health aducanumab Aduhelm Alzheimer's biomarkers Alzheimer's drug Alzheimers-disease amyloid Biogen clinical-trials FDA FDA drug approval process tau Source Type: blogs

Reflection on 40 Years of HIV/AIDS Research
In this jointly written Director ’ s Message, NIMH director Dr. Joshua Gordon and Dr. Maureen Goodenow, associate director for AIDS Research and director of the Office of AIDS Research at the National Institutes of Health, discuss 40 years of NIMH and NIH support for HIV/AIDS research. (Source: NIMH Directors Blog)
Source: NIMH Directors Blog - June 8, 2021 Category: Psychiatry Authors: Joshua Gordon Source Type: blogs

How to Have More Fun While Caregiving for Someone Living with Dementia
Many dementia caregivers feel as though they are treading water just to avoid sinking under the often exhausting pressures associated with dementia care. But consciously changing your attitude can, with practice, significantly change how your days, and those of your loved one, unfold. Here are some tips to get started. See the full slideshow on HealthCentral for some tips about how to have more fun while caregiving: Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I don't want it to end.” ...Craig William Dayton, Film Com...
Source: Minding Our Elders - May 27, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Stress and Alzheimer's: More Evidence Strengthens the Link
Stress has long been considered a major risk for developing Alzheimer’s, but there hasn’t been any real understanding as to why this is so. Now, researchers at the Center for Translational Research in Neurodegenerative Disease at the University of Florida think that they’ve come closer to discovering the connection. Dr. Todd Golde, director of the Center, and his team have found how a hormone released by the brain in response to the body’s stress increases the production of a protein associated with Alzheimer's.  Continue reading on HealthCentral to learn more about how stress could possibly affect your...
Source: Minding Our Elders - May 26, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Helpful Suggestions to Help Caregivers Weather Criticism from Outside Sources
Family caregiving is more of an art than a science. Most people who take on the challenge of family caregiving do the best that they can under their unique circumstances, yet, they often receive criticism, sadly even from other caregivers. How can family caregivers who are already doing so much for their loved one(s) weather criticism from outsiders about how they provide care? Continue to HealthCentral to view the entire slideshow about how caregivers sometimes have to detach from outside criticism: Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it ...
Source: Minding Our Elders - May 24, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Debate: Are depression and dementia two sides of the same coin? And, if they are, how to best approach treatment?
This article was originally published on The Conversation. News in Context: Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors Repetitive negative thinking may increase (or perhaps be caused by) cognitive decline and Alzheimer’s pathology Study: Hearing aids may help older adults delay dementia, depression, anxiety, and falls The post Debate: Are depression and dementia two sides of the same coin? And, if they are, how to best approach treatment? appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - May 21, 2021 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimers-disease antidepressants cognition cognitive decline Cognitive-impairment coronavirus COVID-19 dementia depression hippocampus memory Source Type: blogs

Hearing Loss Addressed Early Can Help Protect Brain
Since mild hearing loss is considered part of normal aging it's rarely treated until the loss is at a later stage. However, now that hearing loss is known to affect our risk of developing dementia, this casual approach needs to be reconsidered.A recent study confirms this. Anu Sharma of the Department of Speech-Language and Hearing Science at the University of Colorado and her team have applied fundamental principles of neuroplasticity, which is the brain’s ability to forge new connections, as a way to adapt to hearing loss. Continue reading more on HealthCentral about how even mild hearing loss could be damaging your br...
Source: Minding Our Elders - May 20, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Hearing Aids Help Balance, Prevent Falls for Some Elders
Photo credit William Krause According to the Centers for Disease Control and Prevention (CDC), falls are the leading cause of both fatal and nonfatal injuries for people over 65. Falls can cause moderate to severe injuries, such as hip fractures and head traumas, and can increase the risk of early death. Fortunately, falls are a public health problem that is largely preventable. The CDC suggests these steps as a start: Continue reading on HealthCentral to learn more about hearing difficulties and fall prevention: Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver...
Source: Minding Our Elders - May 19, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated. Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth https://www.fightaging.org/archi...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs