Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity Gene Cisd2 Improves Liver Function in Aged Mice
Cisd2 is one of the few genes shown to regulate life span in both directions in animal models; less of it shortens life span, while overexpression extends life. Researches here focus on the effects of cisd2 on liver function in mice, showing that maintaining high levels of cisd2 expression into old age beneficially impacts a number of processes implicated in degenerative aging and liver disease. This isn't the only organ in which cisd2 expression has measurable effects; other groups have studied cisd2 in the heart, for example.
The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying l...
Source: Fight Aging! - December 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Multistep Lateral Flow Devices Perform Advanced Assays
Researchers at Georgia Tech have developed a lateral flow test platform that can perform advanced assays that would otherwise require a laboratory. By controlling the flow of liquid through the lateral flow test, the research team designed it so that it can perform advanced multistep assays that do not require sophisticated lab equipment and significant periods of time. So far, they have designed advanced dipstick tests that can detect both COVID-19 and influenza simultaneously, and others that can perform immunoassays to detect Zika virus, HIV, hepatitis B virus, or malaria.
Lateral flow assays, otherwise ...
Source: Medgadget - November 10, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Pathology Public Health georgiatech Source Type: blogs
DNA Origami to Trap Viruses Inside Body
Researchers at the Technical University of Munich have developed a method to create tiny virus traps that can bind viral particles and render them harmless within the body. The technique relies on DNA origami to create self-assembling hollow nanocapsules, which are lined with molecules that will bind viruses and prevent them from leaving. With a viral pandemic currently running riot, such technologies should be very welcome for the future.
Effective anti-viral drugs are elusive for many viral infections, COVID-19 being no exception. These researchers have developed a new type of anti-viral technology that does not rely ...
Source: Medgadget - July 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Nanomedicine Source Type: blogs
Rhode Island Makes Harm Reduction History By Legalizing Safe Consumption Sites
Jeffrey A. SingerRhode Island made history yesterday, as it became the first state to legalize safe consumption sites. Governor Daniel McKeesigned a bill that will set up two pilot programs within the state dubbed “harm reduction centers,” both of which will receive no taxpayer funding but will be financed by private donations and foundations.In 2019 and 2020 I testified before the Maryland legislature which was consideringlegalizing safe consumption sites. Alas, that didn ’t happen.Safe consumption sites, also called safe injection sites, have been in existence since the mid ‐1980s, and now operate in...
Source: Cato-at-liberty - July 8, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
How Big Pharma Bought Big Media for $6 Billion: The Unintended Consequences of Direct-to-Consumer Drug Advertising
Media, whether broadcast, streamed, or print, is a lifeline of information for most Americans. Updates on the pandemic, results of an election, knowing whether you are in the path of an oncoming hurricane or snowstorm—we are alerted by news reports and thereby dependent on the factual information they provide. Media informs, shapes opinions, keeps us out of harm’s way. Despite the public pummeling media has received over the past few years, media remains the means through which Americans view much of their world. What the media reports—or does not report—is therefore crucial to shaping opinion and behavior.
There...
Source: Wheat Belly Blog - June 18, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open undoctored wheat belly Source Type: blogs
Risky Choices: Causes of Hepatitis
A diagnosis of hepatitis can cause a variety of feelings, maybe even shame, embarrassment or fear....The postRisky Choices: Causes of Hepatitis appeared first onCliffside Malibu. (Source: Cliffside Malibu)
Source: Cliffside Malibu - May 27, 2021 Category: Addiction Authors: ebarbour Tags: Addiction Medical cocaine drug addiction Hepatitis heroin Malibu rehab treatment opioids private rehab treatment in Malibu substance addiction Source Type: blogs
All you need to know about waterborne diseases
Waterborne diseases are contracted through exposure to contaminated water including drinking water, water used in food preparation, and swimming water.
They can be caused by bacteria, viruses, and parasites. Below is a partial list of waterborne disease pathogens, their microbial classification, and their resulting illnesses.
Classification
Microorganism
Disease
Bacterium
Campylobacter spp.
Campylobacteriosis
Bacterium
Escherichia coli
E. Coli Diarrhea
Bacterium
Legionella pneumophila
Legionnaires’ Disease
Bacterium
Salmonella enterica
Salmonellosis
Bacterium
Salmonella typhi
Typhoid fever
...
Source: GIDEON blog - January 14, 2021 Category: Databases & Libraries Authors: Kristina Symes Tags: Microbiology News Tips Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Kimer Med is Crowdfunding Early Stage Work to Commercialize DRACO Antiviral Technology
Kimer Med is a New Zealand biotech startup in the very early stages of work on improvement and commercialization of the DRACO antiviral technology. This approach works by selectively destroying cells that host viral replication, and has been shown to be effective for a few presently challenging viral infections in animal models. In principle it is a platform extensible to any viral infection. Unfortunately DRACO fell into the usual chasm, made up of a lack of funding for later stage academic research, a lack of strong-willed iconoclasts willing to go to bat for it, and a lack of interest in the pharmaceutical industry for ...
Source: Fight Aging! - November 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Hepatitis C
is a recently discovered disease. Harvey J. Alter identified the variant form of Hepatitis during the 70s, which then became known as a ‘non-A, non-B Hepatitis (NANBH)’. In the 1980s, Michael Houghton and his team isolated the genome of the new virus, and it was named ‘Hepatitis C’. Finally, in 1997 Charles M. Rice proved that the virus is a disease agent, capable of acting alone to cause Hepatitis.
This year’s Nobel Prize in Medicine has been jointly awarded to Harvey J. Alter, Michael Houghton, and Charles M. Rice for the discovery of the virus. Their contributions (illustrated below) have led to improved unde...
Source: GIDEON blog - November 10, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs
Hepatitis A in the United States
Few Americans are aware of a major epidemic that has taken hold of large areas of their country in recent years – by a disease that is easily diagnosed and prevented. Sadly, public – and even professional interest in these events have been overshadowed by COVID-19.
AN UPTICK IN CASES
Hepatitis A had been largely under control until three years ago and can be easily prevented through the use of a safe and effective vaccine.
From January 2017 to January 2019, at least 26 separate outbreaks were reported, to a total of 11,628 cases and 99 deaths, nationwide. Homeless individuals and users of illicit dru...
Source: GIDEON blog - October 21, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Outbreaks Source Type: blogs
Nobel Prize for discovery of hepatitis C virus
The 2020 Nobel Prize in Medicine has been awarded to Harvey Alter, Michael Houghton, and Charles Rice for their work leading to the discovery of hepatitis C virus. To me this prize makes a great deal of sense because each of the recipients produced key sequential discoveries, all of which were needed to find a […] (Source: virology blog)
Source: virology blog - October 8, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information 5-1-1 hepatitis C virus infectious viral DNA clone Nobel Prize viruses Source Type: blogs
TWiV 670: Coronavirus vaccine preparedness with Kizzmekia Corbett
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Click arrow to playDownload TWiV 670 (76 MB .mp3, […] (Source: virology blog)
Source: virology blog - October 8, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 influenza virus mRNA-1273 pandemic prefusion conformation respiratory syncytial virus SARS-CoV-2 spike vaccine viral viruses Source Type: blogs
