An Interview with Jim Mellon, and Update on Juvenescence
This interview with Jim Mellon opens with an update on some of the recent investment activities of Juvenescence, founded last year in order to participate in the enormous market opportunity afforded by the development of the first working rejuvenation therapies. It is in Mellon's self-interest to help educate the world about the size of this market, and draw in other, larger entities that will help to carry his portfolio companies to the finish line. So he is doing just that, and in doing so benefits us all. His advocacy will help all fronts in fundraising for research and development in this field.
That advocacy co...
Source: Fight Aging! - June 4, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
TWiEVO 31: Virus archaeology, or when the human genome is the junk
Nels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; ov...
Source: virology blog - May 19, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Evolution ancient dna ancient viral genome Bronze Age hepatitis b virus Medieval period virology virus archaeology Source Type: blogs
MKSAP: 28-year-old man with lower-extremity edema
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 28-year-old man is evaluated for a 2-month history of progressive lower-extremity edema, weight loss, and fatigue. Medical history is significant for recreational use of inhaled cocaine; he denies injection drug use. He has no other known medical issues and takes no medications.
On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 130/90 mm Hg, pulse rate is 90/min, and respiration rate is 20/min. BMI is 28. Temporal wasting is present. The lungs are clear. Cardiac examination is norm...
Source: Kevin, M.D. - Medical Weblog - May 19, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Infectious Disease Nephrology Source Type: blogs
PrEP: Protection against HIV in a pill?
HIV (the human immunodeficiency virus) weakens the human immune system and destroys the important cells that fight disease and infection. A person can get HIV when bodily fluids — including blood, semen, pre-seminal fluid, rectal fluids, or vaginal fluids of a person with the virus — come in contact with a mucous membrane or damaged tissue. HIV can be transmitted through breast milk, or when a contaminated needle or syringe comes into direct contact with the bloodstream.
There is no cure for HIV, but with proper medical care the virus and its effects can be controlled. HIV transmission can be reduced by consistent use ...
Source: Harvard Health Blog - May 18, 2018 Category: Consumer Health News Authors: Meera Sunder, MBBS, MRCOG Tags: Health HIV Infectious diseases Source Type: blogs
Death by donut
I don’t mean that you will be struck down by simply stepping into a Dunkin’ Donuts. I mean that donuts and others things wheat and grains will substantially abbreviate y0ur life, or at least make your time on earth a lot more miserable.
I’ve been accused of exaggeration to get the no-wheat, no-grain message through. But if you see what I see every day, I think that you would agree: The consumption of wheat and grains is entirely inappropriate for humans; we exchange near-term calories for deterioration of long-term health that takes numerous forms. And when you see lives completely turned around by banish...
Source: Wheat Belly Blog - May 9, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle autoimmune bowel flora diabetes gluten-free grain-free grains Inflammation joint pain undoctored Source Type: blogs
Death by donut
I don’t mean that you will be struck down by simply stepping into a Dunkin’ Donuts. I mean that donuts and others things wheat and grains will substantially abbreviate your life, or at least make your time on earth a lot more miserable.
I’ve been accused of exaggeration to get the no-wheat, no-grain message through. But if you see what I see every day, I think that you would agree: The consumption of wheat and grains is entirely inappropriate for humans; we exchange near-term calories for deterioration of long-term health that takes numerous forms. And when you see lives completely turned around by banish...
Source: Wheat Belly Blog - May 9, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle autoimmune bowel flora diabetes gluten-free grain-free grains Inflammation joint pain undoctored Source Type: blogs
A physician makes the case for some routine labs
Many medical organizations have recently been promoting focused and individualized lab testing for routine screening or when pursuing a diagnosis. Research has shown that the “shotgun” approach to lab testing usually leads to further invasive testing which has not been proven to significantly alter morbidity or mortality.
Additionally, tests rely on pre-test probabilities and can have false-positive or negative results and even lead to adverse events from the follow-up testing. In response to this, medical organizations have created many resources to help educate and guide physicians from over-testing. The American Col...
Source: Kevin, M.D. - Medical Weblog - May 1, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/shmuel-golfeyz" rel="tag" > Shmuel Golfeyz, MD < /a > Tags: Conditions Gastroenterology Hospital-Based Medicine Primary Care Source Type: blogs
3 ways to help get more children immunized
Follow me on Twitter @drClaire
There is much to celebrate during National Infant Immunization Week this year. More than 90% of children 19 to 35 months have received all the recommended doses of vaccines for their age against polio, measles, mumps, rubella, chicken pox, and hepatitis B — and more than 80% have received all the recommended protection against diphtheria, tetanus, pertussis, pneumococcus, and Haemophilus influenzae.
But there are also reasons to be concerned. Only 72% have had all the recommended vaccines, which means one in four children is missing at least one. Even more concerning, studies show that ther...
Source: Harvard Health Blog - April 24, 2018 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Infectious diseases Parenting Vaccines Source Type: blogs
‘ Going to Extremes ’ Hall of Fame
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
In 2012, Greg Kelly suggested that LITFL collate the most extreme ‘medical extremes’.
This is how things currently stand:
ParameterLevelDiagnosisSubmitted by
Ammonia514 umol/LTorsten Behrens
Base excess (postive)40.6 mmol/LChronic Type 2 respiratory failureJakob Mathiszig-Lee
Bilirubin1113 umol/lDrug-induced hepatitis (anabolic steroids)Jurij Hanžel
Blood pressure345/245 mmHgDuring weightlifting (P. Palatini et al, 1989: https://www.ncbi.nlm....
Source: Life in the Fast Lane - April 21, 2018 Category: Emergency Medicine Authors: Chris Nickson Tags: Emergency Medicine Intensive Care Investigation extremes hall of fame Investigations parameters Physiology Source Type: blogs
Is " Curing Patients " a Good Business Model for Pharma?
An interesting point was made in a recent article that the stock market may"punish" companies likeGilead Sciences which has developed a drug called Harvoni to cure hepatitis C. The supposed reason for the punishment is that the prospects for drug profits will diminish as its highly effective use continues (see:Goldman Sachs report:"Is curing patients a sustainable business model?"). Below is an excerpt from the article:In Goldman Sachs's April 10 report,"The Genome Revolution," its analysts ponder the rise of biotech companies who believe they will develop"one-shot" cures f...
Source: Lab Soft News - April 17, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Genomic Testing Healthcare Business Medical Consumerism Medical Ethics Medical Research Pharmaceutical Industry Public Health Source Type: blogs
Are hepatits C drugs too expensive? Analyzing the pros and cons.
The last few years have been marked by public outcry over the costs of novel prescription drugs, such as the hepatitis C medication sofosbuvir (brand name Sovaldi), which are highly efficacious but extremely expensive.
On the one hand, sofosbuvir produces cure rates of >90%, a figure that seemed unthinkable a few decades ago. On the other, it is priced at approximately $1000 per pill ($60,000–$90,000 for a treatment course), making it unaffordable for many patients. This price tag has spurred physician and advocacy groups to call for price lowering so that more patients can benefit. In turn, the drug manufacturer ha...
Source: Kevin, M.D. - Medical Weblog - April 5, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/joshua-liao" rel="tag" > Joshua Liao, MD < /a > Tags: Conditions Gastroenterology Source Type: blogs
LITFL Review 325
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Welcome to the 325th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM.
Readers can subscribe to LITFL review RSS or LITFL review EMAIL subscription
The Most Fair Dinkum Ripper Beauts of the Week
The New York T...
Source: Life in the Fast Lane - April 2, 2018 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
MKSAP: 57-year-old man with chronic hepatitis C infection
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 57-year-old man is evaluated during a routine examination. His medical history is notable for chronic hepatitis C infection with cirrhosis, which was diagnosed 3 years ago. He undergoes surveillance ultrasound for hepatocellular carcinoma every 6 months.
On physical examination, temperature is 36.8 °C (98.2 °F), blood pressure is 110/82 mm Hg, pulse rate is 65/min, and respiration rate is 18/min; BMI is 22. Muscle wasting and scleral icterus are noted. There is no flank dullness and no asterixis.
Ultrasound ...
Source: Kevin, M.D. - Medical Weblog - March 31, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Knowing when to screen … and when to quit
Follow me on Twitter @RobShmerling
Let us sing the praises of good medical screening tests.
These are the tests that can detect medical problems before they become untreatable and before they cause complications or even death. Even better are those screening tests that detect “predisease” — abnormalities that aren’t dangerous on their own but can lead to problems later.
According to the US Preventive Services Task Force, relatively few screening tests are considered good enough to routinely recommend for adults, including
mammography for breast cancer (women)
Pap smear for cervical cancer (women)
bone density test...
Source: Harvard Health Blog - March 1, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cancer Health Prevention Screening Source Type: blogs
It’s in the Urine
"I just put a young woman in her mid-30s back in room 9," the triage nurse said. I made a mental note that that was the GYN room. The nurse continued, "She feels bad, fatigued, and just not right in her stomach." The obvious question flew from my mouth. "Is she pregnant?""I have the urine, but the quality controls are being run now, so it will be a few minutes."I glanced at the EMR before heading back to the room: normal vitals, no fever, no medications, a couple of kids, no surgeries, last period three weeks before. Not much there to go on, but I could see her while waitin...
Source: Lions and Tigers and Bears - February 28, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
