Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges
Cannabinoids are a group of bioactive compounds abundantly present in Cannabis sativa plant. The active components of cannabis with therapeutic potential are known as cannabinoids. Cannabinoids are divided into three groups: plant-derived cannabinoids (phytocannabinoids), endogenous cannabinoids (endocannabinoids), and synthetic cannabinoids. These compounds play a crucial role in the regulation various physiological processes including the immune modulation by interacting with the endocannabinoid system (A complex cell-signaling system). Cannabinoid receptor type 1 (CB1) stimulates the binding of orexigenic peptides and i...
Source: Frontiers in Immunology - December 4, 2023 Category: Allergy & Immunology Source Type: research
Molecules, Vol. 28, Pages 7826: Extraction of Active Compounds from Mixtures of Hemp (Cannabis sativa) with Plants of the Zingiberaceae Family
In this study, hemp (Cannabis sativa) and three members of the Zingiberaceae family, ginger (Zingiber officinale), turmeric (Curcuma longa), and cardamom (Elettaria cardamomum), were extracted simultaneously, and their bioactive component values were investigated. Two extraction methods were used, namely ultrasound-assisted extraction with ethanol and supercritical fluid extraction with carbon dioxide. First, extracts were obtained from separate plant materials. Then, hemp was extracted in combination with ginger, turmeric, and cardamom in a 1:1 ratio. The extracts obtained were evaluated for their antioxidant activity and...
Source: Molecules - November 28, 2023 Category: Chemistry Authors: Vesna Postru žnik Taja Žitek Makoter Darko Gori čanec Petra Kotnik Željko Knez Ma ša Knez Marevci Tags: Article Source Type: research
Hemp seed globulin-alginate nanoparticles for encapsulation of Cannabisin A with enhanced colloidal stability and antioxidant activity
This study develops hemp seed globulin (GLB)-alginate (ALG) nanoparticles (GANPs) for Cannabisin A (CA) stabilization under environmental stress and during pepsin digestion. The optimal GLB: ALG mass ratio of 1: 1.5 was determined for GANPs formation at pH 3.5, resulting in a high yield of 95.13 ± 0.91 %, a ζ-potential of -35.73 ± 1.04 mV, a hydrodynamic diameter of 470.67 ± 11.36 nm, and a PDI of 0.298 ± 0.016. GANPs were employed to encapsulate CA, achieving a high loading capacity of 13.48 ± 0.04 μg mg-1. FTIR analysis demonstrated that the formation of CA-GLB-ALG nanoparticles (CGANPs) involves electrostatic int...
Source: International Journal of Biological Macromolecules - November 24, 2023 Category: Biochemistry Authors: Peng-Wei Xu Xiao-Jie Yue Xiao-Fan Yuan Bing Zhao Source Type: research
Comparison of deep-litter bedding materials and analysis of semen traits in Pi étrain boars: A randomized controlled field study
Anim Reprod Sci. 2023 Nov 16;259:107379. doi: 10.1016/j.anireprosci.2023.107379. Online ahead of print.ABSTRACTExternal factors can affect reproductive traits of breeding boars and especially the sensitive process of spermatogenesis. The aim of this study was to investigate probable influences of bedding materials (chipsy wood shavings (CWS), hemp straw (HS), linen straw (LS), spelt husks (SH), and regional wood shavings (RWS)) on semen traits of 40 randomly selected Piétrain boars (8 boars per group, age: 2.35 ± 1.23 years). After a six-week adaptation period, 40 fresh semen samples were collected weekly for four weeks ...
Source: Animal Reproduction Science - November 23, 2023 Category: Zoology Authors: Anine Riedel Laura Pieper Matthias Lautner Claus Leiding Markus Jung Martin Schulze Source Type: research
Comparison of deep-litter bedding materials and analysis of semen traits in Pi étrain boars: A randomized controlled field study
Anim Reprod Sci. 2023 Nov 16;259:107379. doi: 10.1016/j.anireprosci.2023.107379. Online ahead of print.ABSTRACTExternal factors can affect reproductive traits of breeding boars and especially the sensitive process of spermatogenesis. The aim of this study was to investigate probable influences of bedding materials (chipsy wood shavings (CWS), hemp straw (HS), linen straw (LS), spelt husks (SH), and regional wood shavings (RWS)) on semen traits of 40 randomly selected Piétrain boars (8 boars per group, age: 2.35 ± 1.23 years). After a six-week adaptation period, 40 fresh semen samples were collected weekly for four weeks ...
Source: Animal Reproduction Science - November 23, 2023 Category: Zoology Authors: Anine Riedel Laura Pieper Matthias Lautner Claus Leiding Markus Jung Martin Schulze Source Type: research
Comparison of deep-litter bedding materials and analysis of semen traits in Pi étrain boars: A randomized controlled field study
Anim Reprod Sci. 2023 Nov 16;259:107379. doi: 10.1016/j.anireprosci.2023.107379. Online ahead of print.ABSTRACTExternal factors can affect reproductive traits of breeding boars and especially the sensitive process of spermatogenesis. The aim of this study was to investigate probable influences of bedding materials (chipsy wood shavings (CWS), hemp straw (HS), linen straw (LS), spelt husks (SH), and regional wood shavings (RWS)) on semen traits of 40 randomly selected Piétrain boars (8 boars per group, age: 2.35 ± 1.23 years). After a six-week adaptation period, 40 fresh semen samples were collected weekly for four weeks ...
Source: Animal Reproduction Science - November 23, 2023 Category: Zoology Authors: Anine Riedel Laura Pieper Matthias Lautner Claus Leiding Markus Jung Martin Schulze Source Type: research
Production and identification of immunomodulatory peptides in intestine cells obtained from hemp industrial by-products
In this study, ten hemp protein hydrolysates (HPHs) were obtained by enzymatic hydrolysis with two food-grade proteases from a hemp protein isolate and the inflammatory properties were evaluated in Caco-2 cell line. To this end, the gene expression and the release of proinflammatory and anti-inflammatory cytokines by Caco-2 cells stimulated with bacterial lipopolysaccharide and treated with HPHs at concentrations of 50 and 100 μg/mL were analyzed. The peptides contained in each HPH were identified and those with higher quality of the match in the spectrum were subjected to in silico analyses to determine which peptides we...
Source: Cell Research - November 21, 2023 Category: Cytology Authors: Sergio Montserrat-de la Paz Alvaro Villanueva-Lazo Francisco Millan Victoria Martin-Santiago Fernando Rivero-Pino Maria C Millan-Linares Source Type: research
The Marketing and Perceptions of Non-Tobacco Blunt Wraps on Twitter
CONCLUSIONS: The large proportion of organic tweets is indicative of the nascency of N-TBWs, which will need to be marketed more extensively if they are to replace cigar products used by blunt smokers.PMID:37982451 | DOI:10.1080/10826084.2023.2280572 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - November 20, 2023 Category: Addiction Authors: Joshua U Rhee Yicong Huang Aurash J Soroosh Sadeem Alsudais Shengquan Ni Avinash Kumar Jacob Paredes Chen Li David S Timberlake Source Type: research
Non-covalent interaction between hemp seed globulin and two hemp seed phenolic compounds: Mechanism and effects on protein structure, bioactivity, and in vitro simulated digestion
This study focused on elucidating the non-covalent interactions between hemp seed globulin (GLB) and two hemp seed phenolic compounds, Cannabisin A (CA) and Cannabisin B (CB), and to explore these interactions on the protein's structure, conformation, and functionality. Fluorescence quenching and thermodynamic analysis revealed that static quenching governed non-covalent interaction processes, with hydrogen bonds and van der Waals forces functioning as major forces. This was further substantiated by molecular docking studies. The binding affinity order was CA > CB, indicating that the specific phenolic compound had a no...
Source: International Journal of Biological Macromolecules - November 17, 2023 Category: Biochemistry Authors: Peng-Wei Xu Xiao-Jie Yue Xiao-Fan Yuan Bing Zhao Source Type: research
Industrial hemp (Cannabis sativa L.)-a valuable alternative crop for growing in agricultural soils contaminated with heavy metals
Environ Sci Pollut Res Int. 2023 Oct 26. doi: 10.1007/s11356-023-30474-z. Online ahead of print.ABSTRACTHemp (Cannabis sativa L.) is a multiuse plant, which has been abundantly studied for phytoremediation purposes in recent years. The majority of experiments were performed in greenhouses with potted plants where hemp showed promising results. Only few studies tested hemp on site in heavy metal-polluted agricultural soil in real environmental conditions and practical assessments of hemp phytoremediation feasibility are lacking. We conducted a comprehensive study using 2 legal industrial hemp varieties (Futura 75 and Tisza)...
Source: Environmental Science and Pollution Research International - October 26, 2023 Category: Environmental Health Authors: Marko Flaj šman Katarina Ko šmelj Helena Gr čman Darja Kocjan A čko Marko Zupan Source Type: research
The miRNA –mRNA regulatory networks of the response to NaHCO3 stress in industrial hemp (Cannabis sativa L.)
Industrial hemp is an important industrial crop and has strong resistance to saline-alkaline stress. However, research on the industrial hemp response to NaHCO3 stress is limited. Therefore, the response mechanis... (Source: BMC Plant Biology)
Source: BMC Plant Biology - October 24, 2023 Category: Biology Authors: Kun Cao, Yufeng Sun, Xiaoyan Zhang, Yue Zhao, Jing Bian, Hao Zhu, Pan Wang, Baochang Gao, Xiaoli Sun, Ming Hu, Yongxia Guo and Xiaonan Wang Tags: Research Source Type: research
