A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: Am J Trop Med Hyg - April 5, 2024 Category: Infectious Diseases Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: Am J Trop Med Hyg - April 5, 2024 Category: Infectious Diseases Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: Am J Trop Med Hyg - April 5, 2024 Category: Infectious Diseases Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs
Am J Trop Med Hyg. 2024 Apr 2:tpmd230534. doi: 10.4269/ajtmh.23-0534. Online ahead of print.ABSTRACTChad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate® larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulati...
Source: Am J Trop Med Hyg - April 5, 2024 Category: Infectious Diseases Authors: Hannah Smalley Pinar Keskinocak Julie Swann Christopher Hanna Adam Weiss Source Type: research
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test
In conclusion, ATT, which requires unnecessary animal usage and competes for resources which otherwise can be spent on innovative medicine research, should be deleted permanently as batch release test by regulatory authorities around the world.PMID:38561146 | DOI:10.1016/j.yrtph.2024.105617 (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - April 1, 2024 Category: Toxicology Authors: Ryan Meng Mark van Ooij Yali Li Yunhai Zhang Jianxun Xie Source Type: research
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test
In conclusion, ATT, which requires unnecessary animal usage and competes for resources which otherwise can be spent on innovative medicine research, should be deleted permanently as batch release test by regulatory authorities around the world.PMID:38561146 | DOI:10.1016/j.yrtph.2024.105617 (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - April 1, 2024 Category: Toxicology Authors: Ryan Meng Mark van Ooij Yali Li Yunhai Zhang Jianxun Xie Source Type: research
Annals 80th anniversary: Immunotherapy for food allergy
The 1944 edition of the Annals of Allergy, Asthma& Immunology held the seed of an idea that today, some 80 years later, has come to define the field of food allergy. The article —entitled “Experimental approach to oral treatment of food allergy: Chemistry of food propeptans”—was conducted by Austrian dermatologist Erich Urbach, a war émigré who had escaped Nazi persecution to take up a position at the University of Pennsylvania.1 Alongside detailed chemical explan ations of the hydrolysis of food proteins, the article contained a surprising laboratory finding: guinea pigs who had been “allergenized” to egg wh...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Brit Trogen, Anna Nowak-Wegrzyn Tags: Editorial Source Type: research
