Use of guinea pig data to obtain starting points for skin sensitisation risk assessment - A commentary
Regul Toxicol Pharmacol. 2024 Feb 28;148:105584. doi: 10.1016/j.yrtph.2024.105584. Online ahead of print.ABSTRACTThe increasing drive to understand the likelihood of skin sensitisation from plant protection products (PPPs) in workers and the general public has resulted in recent initiatives to establish a quantitative risk assessment (QRA) methodology applicable to these products and their exposure scenarios. The effective evaluation of skin sensitising substances requires not only the identification of that toxicological hazard, but also determination of relative sensitising potency. Typically, this has been achieved by i...
Source: Regulatory Toxicology and Pharmacology : RTP - February 28, 2024 Category: Toxicology Authors: David Basketter Namali Corea Marco Corvaro Arthur Grivel Felix M Kluxen Neil Morgan Christiane Wiemann Source Type: research
Valorization of guinea grass seed (Megathyrsus maximus): Synthesis and utilization of cellulose microfiber to reinforce esterified and cross-linked guinea starch films
In conclusion, esterified starch-based films exhibited superior barrier properties and flexibility. On the contrary, cross-linked starch films demonstrated higher tensile strength and lower water solubility.PMID:38417759 | DOI:10.1016/j.ijbiomac.2024.130434 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - February 28, 2024 Category: Biochemistry Authors: Divya Deep Yogesh Kumar Yograj Bist D C Saxena Source Type: research
Characteristics of Hospitalized COVID-19 Patients at Admission and Factors Associated with Clinical Severity in Low- and Middle-Income Countries: An Observational Study
The objective of this observational, prospective, hospital-based multicentric study was to describe clinical features and outcomes of laboratory-confirmed COVID-19 patients hospitalized in each of the participating centers in Bangladesh, Guinea, Ivory Coast, Lebanon, Madagascar, and Mali during the first year of the pandemic (March 5, 2020 to May 4, 2021). The study outcome was the clinical severity of COVID-19, defined as hospitalization in intensive care unit or death. Multivariate logistic regression models were performed to identify independent variables associated with disease severity. Overall, 1,096 patients were in...
Source: The American Journal of Tropical Medicine and Hygiene - February 27, 2024 Category: Tropical Medicine Authors: Marianne Abifadel Kaousar Ahmmed Sayera Banu Ibrahima Camara Fahmida Chowdhury Daouda Coulibaly Georges Dabar C édric Dananché Rachel Daw Zakiul Hassan Magali Herv é Ariful Islam Florence Komurian-Pradel Jean-Pierre Kouam é Bourema Kouriba Josette Naj Source Type: research
Characteristics of Hospitalized COVID-19 Patients at Admission and Factors Associated with Clinical Severity in Low- and Middle-Income Countries: An Observational Study
The objective of this observational, prospective, hospital-based multicentric study was to describe clinical features and outcomes of laboratory-confirmed COVID-19 patients hospitalized in each of the participating centers in Bangladesh, Guinea, Ivory Coast, Lebanon, Madagascar, and Mali during the first year of the pandemic (March 5, 2020 to May 4, 2021). The study outcome was the clinical severity of COVID-19, defined as hospitalization in intensive care unit or death. Multivariate logistic regression models were performed to identify independent variables associated with disease severity. Overall, 1,096 patients were in...
Source: Am J Trop Med Hyg - February 27, 2024 Category: Infectious Diseases Authors: Marianne Abifadel Kaousar Ahmmed Sayera Banu Ibrahima Camara Fahmida Chowdhury Daouda Coulibaly Georges Dabar C édric Dananché Rachel Daw Zakiul Hassan Magali Herv é Ariful Islam Florence Komurian-Pradel Jean-Pierre Kouam é Bourema Kouriba Josette Naj Source Type: research
Characteristics of Hospitalized COVID-19 Patients at Admission and Factors Associated with Clinical Severity in Low- and Middle-Income Countries: An Observational Study
The objective of this observational, prospective, hospital-based multicentric study was to describe clinical features and outcomes of laboratory-confirmed COVID-19 patients hospitalized in each of the participating centers in Bangladesh, Guinea, Ivory Coast, Lebanon, Madagascar, and Mali during the first year of the pandemic (March 5, 2020 to May 4, 2021). The study outcome was the clinical severity of COVID-19, defined as hospitalization in intensive care unit or death. Multivariate logistic regression models were performed to identify independent variables associated with disease severity. Overall, 1,096 patients were in...
Source: The American Journal of Tropical Medicine and Hygiene - February 27, 2024 Category: Tropical Medicine Authors: Marianne Abifadel Kaousar Ahmmed Sayera Banu Ibrahima Camara Fahmida Chowdhury Daouda Coulibaly Georges Dabar C édric Dananché Rachel Daw Zakiul Hassan Magali Herv é Ariful Islam Florence Komurian-Pradel Jean-Pierre Kouam é Bourema Kouriba Josette Naj Source Type: research
Characteristics of Hospitalized COVID-19 Patients at Admission and Factors Associated with Clinical Severity in Low- and Middle-Income Countries: An Observational Study
The objective of this observational, prospective, hospital-based multicentric study was to describe clinical features and outcomes of laboratory-confirmed COVID-19 patients hospitalized in each of the participating centers in Bangladesh, Guinea, Ivory Coast, Lebanon, Madagascar, and Mali during the first year of the pandemic (March 5, 2020 to May 4, 2021). The study outcome was the clinical severity of COVID-19, defined as hospitalization in intensive care unit or death. Multivariate logistic regression models were performed to identify independent variables associated with disease severity. Overall, 1,096 patients were in...
Source: Am J Trop Med Hyg - February 27, 2024 Category: Infectious Diseases Authors: Marianne Abifadel Kaousar Ahmmed Sayera Banu Ibrahima Camara Fahmida Chowdhury Daouda Coulibaly Georges Dabar C édric Dananché Rachel Daw Zakiul Hassan Magali Herv é Ariful Islam Florence Komurian-Pradel Jean-Pierre Kouam é Bourema Kouriba Josette Naj Source Type: research
Characteristics of Hospitalized COVID-19 Patients at Admission and Factors Associated with Clinical Severity in Low- and Middle-Income Countries: An Observational Study
The objective of this observational, prospective, hospital-based multicentric study was to describe clinical features and outcomes of laboratory-confirmed COVID-19 patients hospitalized in each of the participating centers in Bangladesh, Guinea, Ivory Coast, Lebanon, Madagascar, and Mali during the first year of the pandemic (March 5, 2020 to May 4, 2021). The study outcome was the clinical severity of COVID-19, defined as hospitalization in intensive care unit or death. Multivariate logistic regression models were performed to identify independent variables associated with disease severity. Overall, 1,096 patients were in...
Source: The American Journal of Tropical Medicine and Hygiene - February 27, 2024 Category: Tropical Medicine Authors: Marianne Abifadel Kaousar Ahmmed Sayera Banu Ibrahima Camara Fahmida Chowdhury Daouda Coulibaly Georges Dabar C édric Dananché Rachel Daw Zakiul Hassan Magali Herv é Ariful Islam Florence Komurian-Pradel Jean-Pierre Kouam é Bourema Kouriba Josette Naj Source Type: research
Analysis and validation of potential ICD-related biomarkers in development of myopia using machine learning
ConclusionLY96 was identified and verified as a ICD-related potential myopia biomarker. Molecular mechanisms or pathways involved in myopia development by LY96 requires further research. (Source: International Ophthalmology)
Source: International Ophthalmology - February 27, 2024 Category: Opthalmology Source Type: research
Widespread distribution of human-infective Enterocytozoon bieneusi genotypes in small rodents in northeast China and phylogeny and zoonotic implications revisited
Acta Trop. 2024 Feb 24:107160. doi: 10.1016/j.actatropica.2024.107160. Online ahead of print.ABSTRACTEnterocytozoon bieneusi features high genetic diversity among host species and environmental sources and over 500 genotypes in 11 phylogenetic groups have been defined. Here we investigated 291 small rodents in Heilongjiang province, northeast China, for the presence of E. bieneusi by PCR of the ribosomal internal transcribed spacer (ITS). Nine of 60 (15.0%) gray squirrels from a park in Harbin, 120 of 201 (59.7%) guinea pigs from a pet shop in Harbin, and two of 30 (6.7%) peridomestic rats from a pasture in Qiqihar were po...
Source: Acta Tropica - February 26, 2024 Category: Infectious Diseases Authors: Shuning Jiang Shui Yu Yaoyu Feng Longxian Zhang Monica Santin Lihua Xiao Wei Li Source Type: research
Comparison of ruminal microbiota, IL-1 β gene variation, and tick incidence between Holstein × Gyr and Holstein heifers in grazing system
ConclusionAdaptations in Holstein × Gyr heifers such as ruminal microbiota, tick resistance, nucleotide substitutions in IL-1β gene, and hormone concentration suggest a better energy metabolism and thermoregulation resulting in better performance in tropical grazing systems. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 26, 2024 Category: Microbiology Source Type: research
Influence of photoperiod and exogenous melatonin on testis morpho-physiology of sexually mature guinea fowl (Numida meleagris)
Anim Reprod Sci. 2024 Jan 10;263:107410. doi: 10.1016/j.anireprosci.2024.107410. Online ahead of print.ABSTRACTThe biological effects of simulated photoperiod and melatonin on the control of reproduction of guinea fowls (Numida meleagris) are not well understood. Herein, thirty (30) sexually mature guinea fowl cocks were randomly assigned to 1-6 groups (n = 5) and subjected to different photoperiodic regimes in the presence or absence of exogenous melatonin (Mel; 1 BW/day, i/m) for eight weeks. Testes of the euthanized cocks were processed for gross morphology, histological, histochemical, and oxidative stress markers. Tes...
Source: Animal Reproduction Science - February 25, 2024 Category: Zoology Authors: Innocent J Gosomji Umar M Bello Tavershima Dzenda Abdullahi Baso Augustine Arukwe Tom A Aire Source Type: research
Influence of photoperiod and exogenous melatonin on testis morpho-physiology of sexually mature guinea fowl (Numida meleagris)
Anim Reprod Sci. 2024 Jan 10;263:107410. doi: 10.1016/j.anireprosci.2024.107410. Online ahead of print.ABSTRACTThe biological effects of simulated photoperiod and melatonin on the control of reproduction of guinea fowls (Numida meleagris) are not well understood. Herein, thirty (30) sexually mature guinea fowl cocks were randomly assigned to 1-6 groups (n = 5) and subjected to different photoperiodic regimes in the presence or absence of exogenous melatonin (Mel; 1 BW/day, i/m) for eight weeks. Testes of the euthanized cocks were processed for gross morphology, histological, histochemical, and oxidative stress markers. Tes...
Source: Animal Reproduction Science - February 25, 2024 Category: Zoology Authors: Innocent J Gosomji Umar M Bello Tavershima Dzenda Abdullahi Baso Augustine Arukwe Tom A Aire Source Type: research
Influence of photoperiod and exogenous melatonin on testis morpho-physiology of sexually mature guinea fowl (Numida meleagris)
Anim Reprod Sci. 2024 Jan 10;263:107410. doi: 10.1016/j.anireprosci.2024.107410. Online ahead of print.ABSTRACTThe biological effects of simulated photoperiod and melatonin on the control of reproduction of guinea fowls (Numida meleagris) are not well understood. Herein, thirty (30) sexually mature guinea fowl cocks were randomly assigned to 1-6 groups (n = 5) and subjected to different photoperiodic regimes in the presence or absence of exogenous melatonin (Mel; 1 BW/day, i/m) for eight weeks. Testes of the euthanized cocks were processed for gross morphology, histological, histochemical, and oxidative stress markers. Tes...
Source: Animal Reproduction Science - February 25, 2024 Category: Zoology Authors: Innocent J Gosomji Umar M Bello Tavershima Dzenda Abdullahi Baso Augustine Arukwe Tom A Aire Source Type: research
Viruses, Vol. 16, Pages 357: Wild Bird-Origin H6N2 Influenza Virus Acquires Enhanced Pathogenicity after Single Passage in Mice
This study demonstrated that the H6N2 subtype wild bird-origin AIV easily acquired the mammalian adaptation. The monitoring and evaluation of H6 wild bird-origin AIV should be strengthened. (Source: Viruses)
Source: Viruses - February 25, 2024 Category: Virology Authors: Siqi Tang Bing Han Chaofan Su Hailing Li Shiyuchen Zhao Haoyu Leng Yali Feng Ying Zhang Tags: Article Source Type: research
SARS-CoV-2 seroprevalence in vaccine-na ïve participants from the Democratic Republic of Congo, Guinea, Liberia, and Mali
In the four years since COVID-19 was declared a global pandemic on March 11, 2020, more than 760 million cases have been reported worldwide leading to a death toll of almost 7 million people [1]. During the first year of the pandemic, while high rates of SARS-CoV-2 infections were reported globally, initial reports suggested that infection rates were significantly lower in sub-Saharan Africa than in other parts of the world [2,3]. Subsequent studies revealed that although seroprevalence was rapidly increasing in sub-Saharan African countries during the start of the pandemic, it was estimated that less than 1% of infections...
Source: International Journal of Infectious Diseases - February 25, 2024 Category: Infectious Diseases Authors: Laverdure Sylvain, Kazadi Donatien, Kone Kadidia, Callier Viviane, Dabitao Djeneba, Dennis Dehkontee, Haidara Mory Cherif, Hunsberger Sally, Mbaya Olivier Tshiani, Ridzon Renee, Sereti Irini, Shaw-Saliba Katy, the InVITE Study Team Source Type: research
