2016 WHO Classification Brain Tumours
WHO brain tumour classification has been updated in 2016. The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both hist...
Source: Sumer's Radiology Site - June 25, 2016 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Don't Believe Statistics
Back in college, I took a statistics class and had to write a paper about the skewing of statistics particularly as done in the media. I think I did pretty well on it. And I did learn not to believe statistics as presented anywhere without thinking about them.Here's an example: A recent study said that being married or having a college education made you more likely to get brain cancer. I'll bet that result was a surprise to the researchers. But you really need to dig a little deeper into the research to understand that isn't really the truth."Using a huge registry of health and other data on all Swedes, European researche...
Source: Caroline's Breast Cancer Blog - June 21, 2016 Category: Cancer & Oncology Tags: cancer research truth Source Type: blogs
American Association of Neuropathologists annual meeting is underway in Baltimore
Dr. Doug Anthony (in foreground) enjoys Special Course atAANP meeting todayThe 92nd Annual Meeting of the American Association of Neuropathologists opened today with a Special Course focusing on the neuropathology of chronic traumatic encephalopathy (CTE). Additionally, two sessions focused on updates to the most recent WHO Classification of CNS Tumors. The day opened with a presentation by Walter Koroshetz, MD, director of the National Institute of Neurological Disorders and Stroke (NINDS). Dr. Koroshetz addressed advances in optical instrumentation in the imaging of brain trauma and the way in which neuropathologist...
Source: neuropathology blog - June 17, 2016 Category: Radiology Tags: meetings Source Type: blogs
Featured Neuropathologist: Roger McLendon, MD
Today I feature the inimitable Dr. Roger McLendon, director of neuropathology at Duke University. McLendon has made major contributions to the field in the area of molecular characterization of gliomas. He has also demonstrated a commitment to professional service, including his current work on the Neuropathology Committee of the College of American Pathologists. Check out this interview with one of the most influential neuropathologists practicing today.....Roger McLendon, MD1. Why did you decide to become a neuropathologist?When I was in college, I asked a buddy of mine who was in vet school what c...
Source: neuropathology blog - June 9, 2016 Category: Radiology Tags: neuropathologists Source Type: blogs
False “balance” about Stanislaw Burzynski’s cancer quackery rears its ugly head again
One common theme that has been revisited time and time again on this blog since its very founding is the problem of how science and medicine are reported. For example, back when I first started blogging, one thing that used to drive me absolutely bonkers was the tendency of the press to include in any… (Source: Respectful Insolence)
Source: Respectful Insolence - June 2, 2016 Category: Surgery Authors: Orac Tags: Cancer Clinical trials Complementary and alternative medicine Pseudoscience Quackery Skepticism/critical thinking antineoplastons diffuse intrinsic pontine glioma DIPG fda Neil Fachon Stanislaw Burzynski Wendy Fachon Source Type: blogs
Summary of the Major Changes in the 2016 WHO Classification of CNS Tumors
Major restructuring of medulloblastomas, with incorporation of genetically defined entitiesAddition of brain invasion as a criterion for atypical meningiomaRestructuring of solitary fibrous tumor and hemangiopericytoma (SFT/HPC) as one entity and adapting a grading system to accommodate this changeExpansion and clarification of entities included in nerve sheath tumors, with addition of hybrid nerve sheath tumors and separation of melanotic schwannoma from other schwannomasExpansion of entities included in hematopoietic/lymphoid tumors of the CNS (lymphomas and histiocytic tumors)Addition of the following newly recognized e...
Source: neuropathology blog - May 27, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
Glioblastoma: Radiopath Correlation Teaching Video
Glioblastoma (GBM) have a preferential spreading along the condensed white matter tracts such as corticospinal tracts and corpus callosum and such appearance is called as butterfly glioma. Here is a video explaining the Radiopath correlation.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - May 18, 2016 Category: Radiology Authors: Sumer Sethi Source Type: blogs
LIVESTRONG Leader Spotlight: Christina
LIVESTRONG Leaders are individuals that make a yearly significant commitment to those in their community affected by cancer by spreading the message of LIVESTRONG. They do this by fundraising, hosting events, bringing LIVESTRONG resources to their local hospitals and more. One of our amazing leaders from Iowa, Tina Metz-Anderson, talks about why she is involved with LIVESTRONG and what she is doing in her community to help spread the LIVESTRONG message.
What is your name, where are you from?
Christina Metz-Anderson, Bettendorf, IA
How are you affected by cancer?
My family was affected by Cancer in 1975 when my mom was dia...
Source: LIVESTRONG Blog - April 3, 2016 Category: Cancer & Oncology Authors: LIVESTRONG Staff Source Type: blogs
Neurofibromatosis-I
Patient with multiple cutaneous lesions on MRI brain shows evidence of thickened and moderately T2 hyperintense optic chiasma with moderate post gadolinium enhancement anteriorly extending till the orbital apex. This may indicate optic glioma. There are areas of T2/FLAIR hyperintensity in the bilateral mesial temporal regions, right globus pallidus region and right pontomesencephalic region, with no significant enhancement, Possible hamartomas. These findings along with cutaneous findings described could indicate diagnosis of Neurofibromatosis I. Advised clinical correlation. The criteria for the diagnosis...
Source: Sumer's Radiology Site - July 1, 2014 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
Horbinski Group develops online tool to estimate likelihood of IDH1/2 mutation in a glioma
Craig Horbinski, MD, PhD.The illustrious Craig Horbinski, MD, PhD wrote in to share a link to an online tool which his team developed which helps triage brain tumor cases that might benefit from additional molecular testing. Here's what the University of Kentucky neuropathologist had to say about this new website: "We have developed an online-based tool to provide a statistical estimate of the likelihood of an IDH1/2 mutation in a glioma, basedon a few easily-obtained parameters. Several variables like patient age, WHO grade, etc. are well-known to correlate with mutations, but no formula has yet been developed ...
Source: neuropathology blog - June 16, 2014 Category: Pathologists Tags: molecular studies Source Type: blogs
Stanislaw Burzynski publishes his antineoplaston results again. It’s no more convincing than last time.
Here we go again. Two months ago, I noted that Dr. Stanislaw Burzynski, the Polish expatriate physician who started out as a legitimate medical researcher and then in the late 1970s took a turn away from science-based medicine and towards being a “brave maverick doctor” through his discovery in blood and urine of substances he… (Source: Respectful Insolence)
Source: Respectful Insolence - June 9, 2014 Category: Surgery Authors: Orac Tags: Cancer Clinical trials Complementary and alternative medicine antineoplastons Crystin Schiff glioma Journal of Cancer Therapy phenylacetate Ric Schiff Stanislaw Burzynski Source Type: blogs
Orphan Drugs - The Seattle Times explains
The mining of rare diseasesThirty years ago, Congress acted to spur research on rare diseases. Today, we have hundreds of new drugs — along with runaway pricing and market manipulation, as drugmakers turn a law with good intentions into a profit engine.By Michael J. Berens and Ken ArmstrongHer vision failed first.Then she fell asleep at school from inexplicable fatigue. Even walking proved difficult, often impossible, as she knocked into furniture and walls. It was like an electrical switch in her body toggled without warning. Some days she was in control, most she was not.Specialists were s...
Source: PharmaGossip - November 11, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs
New Laser Imaging Technique Highlights Brain Tumors Among Healthy Tissue
This image of a human glioblastoma brain tumor in the brain of a mouse was made with stimulated Raman scattering, or SRS, microscopy. The technique allows the tumor (blue) to be easily distinguished from normal tissue (green) based on faint signals emitted by tissue with different cellular structures.
Intracranial cancers usually look the same as the healthy tissue surrounding them. With tumor resection in the brain, it is particularly important to remove the whole of the tumor while damaging as little normal brain matter as possible. A number of techniques exist for differentiating tumors, but each has its limitations.
No...
Source: Medgadget - September 5, 2013 Category: Technology Consultants Authors: Editors Tags: in the news... Source Type: blogs
Dr. Marta Couce joins neuropathology staff at Case Western
Dr. Marta E. CouceMarta E. Couce, MD, PhD, will be joining the staff of University Hospitals of Cleveland, Case Western Reserve University next week. She will teaming up to handle surgical neuropathology with the illustrious Dr. Mark Cohen, who has been on staff at Case since 1993.Dr. Couce attended Medical School in Santiago de Compostela, Spain. She pursued her graduate school training at the same University in the Department of Pathology. After research stints at East Carolina University and the Mayo Clinic, Dr. Couce did her training in Anatomic Pathology at Yale New Haven Hospital, followed by two fellowsh...
Source: neuropathology blog - September 4, 2013 Category: Pathologists Tags: neuropathologists Source Type: blogs
Resident's Flash Card: Neurofibromatosis
Neurofibromatosis - I (von Recklinghausen’s disease)
- autosomal dominant (abnormality is on chromosome 17)
- diagnostic criteria include six or more cafe-au-lait spots, axillary or inguinal freckling, two (or more) neurofibromas, optic glioma (most common CNS neoplasm - occurs in 30-90% and is bilateral in 10-20%), iris hamartoma, distinctive osseous lesions, or a first-degree relative with NF-1
- hypertension may be found with renal artery fibromuscular dysplasia
- neurofibromas can occur in the urinary and gastrointestinal tracts
- increased incidence of all types of neoplasms
- malignant transformation of...
Source: Sumer's Radiology Site - August 19, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
