Course being offered at March 2018 USCAP annual meeting: Non-neoplastic surgical neuropathology that can be mistaken for neoplasia
SC07 - Surgical Neuropathology - The Other StuffThursday, March 22, 2018 - 8:00 am - 11:30 amThis Short Course session includes up to a half-hour break.Session Credits:3 CME and 3 SAMsFacultyBette K. Kleinschmidt-DeMasters, MD, University of Colorado, Aurora, CORichard A. Prayson, MD, Cleveland Clinic, Cleveland, OHAnthony T. Yachnis, MD, University of Florida, Gainesville, FLCourse DescriptionThe majority of cases encountered in surgical neuropathology represent neoplasms. Subsequently, most pathologist, when confronted with a surgical neuropathology case, are usually “thinking tumor” and conjuring up differential dia...
Source: neuropathology blog - February 28, 2018 Category: Radiology Tags: meetings Source Type: blogs
Glioma and VTE
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - October 10, 2017 Category: Internal Medicine Tags: cardiovascular hematology oncology Source Type: blogs
Fight Aging! Newsletter, August 28th 2017
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease.
Early Steps in the Tissue Engineering of Intervertebral Discs
https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/
In this paper, researchers report on progress towards the manufacture of interve...
Source: Fight Aging! - August 27, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The 2017 Summer Scholars Working at the SENS Research Foundation
Each year, the SENS Research Foundation accepts a group of young life science academics and puts them to work on projects in aging research, both at the foundation and in allied laboratories, creating ties between research groups that can help to advance the state of the art. This year's batch has worked on a diverse set of projects that spread out beyond core SENS initiatives such as allotopic expression of mitochondrial genes. Reading through their projects is a reminder that a great deal can be accomplished these days given a small team, a little funding, and an equipped laboratory. Progress in medical research is no lo...
Source: Fight Aging! - August 26, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Ultrasound to Improve Effectiveness of Cancer Drugs: Interview with Focused Ultrasound Foundation ’s Jessica Foley, PhD
Most people think of ultrasound as an imaging modality. Yet, there are many other clinical uses for the high frequency soundwaves. Focused ultrasound waves can promote the opening of the blood-brain barrier, and they can be used to ablate fibroids, among other uses. Yet the potential of ultrasound in clinical medicine is far from fully realized, as new uses and studies evaluating them are rapidly sprouting, and a particularly interesting one involving checkpoint inhibitors to treat stage IV metastatic breast cancer is about to begin. To get a sense for how ultrasound can improve cancer care in combination with checkpoint i...
Source: Medgadget - August 10, 2017 Category: Medical Devices Authors: Editors Tags: Medicine News Source Type: blogs
Johns Hopkins Atlas of Surgical Neuropathology now available on iTunes
Dr. EberhartDr. RodriquezSurgical neuropathology is the focus of volume 3 in the Johns Hopkins Atlases of Pathology.This app was released on March 3, 2017 for iPad download for only $4.99 . Authors Charles Eberhart and Fausto Rodriquez introduce us to the next generation in surgical neuropathology reference with a variety of educational features, updates to the 2016 WHO grading system system for CNS tumors, algorithms for the evaluation of diffuse gliomas, and practice quizzes. Congratulations to Drs. Eberhart and Rodriguez on the creation of a magnificent product! (Source: neuropathology blog)
Source: neuropathology blog - March 7, 2017 Category: Radiology Tags: websites Source Type: blogs
Progressive Multifocal Leukoencephalopathy: MRI
Case Report: 43 y Male, known retroviral status with altered sensorium for MRI shows-Diffuse non-enhancing T2 and FLAIR white matter hyperintensity in supratentorial white matter in all the lobes, middle cerebellar peduncles, right thalamus, corpus callosum with mild mass effect over sulcal spaces& ventricles with subtle bright signal in DWI with sparing of grey matter& subcortical U fibers with unremarkable flow voids, dural sinuses,optic chiasm/intraventricular extension, midline extension. Prominent subependymal vessels& pachymeninges seen on contrast without nodularity. These findings...
Source: Sumer's Radiology Site - March 6, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Mutant IDH1 and thrombosis in gliomas
Craig M. Horbinski, MD PhDDr. Craig Horbinski ofNorthwestern University and colleagues just published a significant paper inActa Neuropathologica entitledMutant IDH1 and thrombosis in gliomas. Horbinski ' s data suggests that, quoting the abstract, " mutant IDH1 has potent antithrombotic activity within gliomas and throughout the peripheral circulation. These findings have implications for the pathologic evaluation of gliomas, the effect of altered isocitrate metabolism on tumor microenvironment, and risk assessment of glioma patients for venous thromboemboli." It should be noted that this paper won theRubinstein Awar...
Source: neuropathology blog - October 3, 2016 Category: Radiology Tags: neoplasms neuropathologists Source Type: blogs
Society for Neuro-Oncology meeting to feature several prominent neuropathologists
David W. Ellison, MD, PhD,one of the presenters at the 2016 SNO meetingThe Society for Neuro-Oncology 2016 Annual Meeting to be held this year in Scottsdale, Arizona on November 16-20 will feature several members of theAmerican Association of Neuropathologists.Peter Canoll will be speaking on " Primary brain tumors – pathology, grading and prognosis – new WHO classification " .Arie Perry will be giving a " WHO overview " .Sandro Santagata will talk on " Advances in the molecular genetics of meningioma " .Dan Brat will present on " IDH-omas " .Cynthia Hawkins will give an overview of pediatric gliomas.Dav...
Source: neuropathology blog - September 29, 2016 Category: Radiology Tags: meetings neuropathologists Source Type: blogs
University of Colorado residents show up in force for CAP16
Left to right: Drs. Robinson, Greer, Roberts, Klein, and Graham (with me kneeling)Five PGY2 pathology residents, the most from a single class in the history of the institution, are presenting posters today and tomorrow at the annual meeting of the College of American Pathologists. Most are neuropathology related. Here are the titles:Caleb Graham,et al. Pilocytic Astrocytoma: A Diagnostic Consideration in Lateral Ventricular TumorsAshley Greer,et al. BRAF Mutational Status in Desmoplastic Infantile Astrocytoma/GangliogliomaColleen Klein,et al. Hemophagocytic Lymphohistiocytosis Discovered Clinically and at Autopsy: A Dual-I...
Source: neuropathology blog - September 26, 2016 Category: Radiology Tags: CAP16 abstracts meetings Source Type: blogs
CAP16 Abstract Highlights - Astrocytoma With a Distinct Molecular Signature: MYB Rearrangement and EGFR Amplification
We report the first case of a pediatric astrocytoma with both MYB rearrangement and EGFR amplification. A 3-year-old boy was found to have a T2 hyperintense, nonenhancing mass in theleft temporal lobe after minor head trauma. Histology showed a diffuse astrocytic tumor with low cell density and bland cytology. Mitotic figures were present, albeit focally, prompting a diagnosis of anaplastic astrocytoma. No necrosis or microvascular proliferation was identified. The Ki-67 labeling index, while generally low, rose to approximately 20%, corresponding to regions of mitotic activity. Interphase fluorescence in situ hybridizatio...
Source: neuropathology blog - September 20, 2016 Category: Radiology Tags: CAP16 abstracts molecular studies neoplasms Source Type: blogs
A Case of Chordoid Glioma of the Third Ventricle
A man in his sixties presented with disequilibrium and hypothermia.A 34 x 28 mm well-circumscribed 3rd ventricular massChordoid architecture with myxoid backgroundAdmixed plasma cells are characteristicChordoid Glioma, WHO grade II (Source: neuropathology blog)
Source: neuropathology blog - August 8, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
H3-K27M immunohistochemical positivity in a case of Diffuse Midline Glioma
(Source: neuropathology blog)
Source: neuropathology blog - August 2, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
A 60-year-old man presents with acute confusion, aggressive behavior, and aphasia
T2-weighted FLAIR MRI A 60-year-old man presents with acute confusion, aggressive behavior, and aphasia. Imaging reveals a heterogeneously enhancing mass (5 x 2 x 2 cm) in the left medial temporal lobe with extensive peripheral edema (image above), but no significant contrast enhancement. A subtotal temporal lobectomy was performed on suspicion of a low-grade glioma.High-power view of biopsy from left temporal lobeThe diagnosis is herpes simplex encephalitis. PCR amplification of DNA from the specimen more specifically identified the causative agent as herpes simplex virus, type 1 (HSV1). The most common identifiable ...
Source: neuropathology blog - July 18, 2016 Category: Radiology Tags: infectious disease Source Type: blogs
Best Post of May 2016 -- MYB-QKI fusion: A novel alteration that may define and drive pediatric angiocentric glioma
The next in our "Best of the Month" series comes from May 12, 2016Angiiocentric gliomaAngiocentric glioma is a rare form of pediatric low-grade gliomas (PLGG), first described in 2005, that arises in the cerebral cortex and shares histological features of astrocytomas and ependymomas. Until now, nothing was known of the genetic events underlying this tumor type. In a recent study published in Nature Genetics, Bhandopadhayay et al (see reference below) used whole genome sequencing and/or RNAseq to show that all seven angiocentric gliomas in their sample set harbored rearrangements in MYB, the most common bein...
Source: neuropathology blog - June 28, 2016 Category: Radiology Tags: Best of the Month series neoplasms Source Type: blogs
