Neurofibromatosis-I

Patient with multiple cutaneous lesions on MRI brain shows evidence of thickened and moderately T2 hyperintense optic chiasma with moderate post gadolinium enhancement anteriorly extending till the orbital apex. This may indicate optic glioma. There are areas of T2/FLAIR hyperintensity in the bilateral mesial  temporal regions, right globus pallidus region and right pontomesencephalic region, with no significant enhancement, Possible hamartomas. These findings along with cutaneous findings described could indicate diagnosis of Neurofibromatosis I.  Advised clinical correlation. The criteria for the diagnosis of NF1 are met in an individual if 2 or more of the following signs are found:Six or more café au lait macules larger than 5 mm in the greatest diameter in prepubertal children and larger than 1.5 cm in postpubertal individualsTwo or more neurofibromas of any type or 1 plexiform neurofibromaMultiple freckles (Crowe sign) in the axillary or inguinal regionA distinctive osseous lesion, such as sphenoid dysplasia or thinning of long bone cortex, with or without pseudoarthrosisOptic gliomaTwo or more iris hamartomas (Lisch nodules) seen on slitlamp or biomicroscopy examinationA first-degree relative (parent, sibling, offspring) with NF1, as diagnosed by using the above criteria.From Sumer's Radiology Site http://www.sumerdoc.blogspot.com -The Top Radiology Magazine. Teleradiology Providers at www.teleradproviders.com Mail us at [e-mail]

Source: Sumer's Radiology Site - July 1, 2014 Category: Radiologists Authors: Sumer Sethi Source Type: blogs