Impact of Weight Loss with Laparoscopic Sleeve Gastrectomy on Left Ventricular Diastolic Function: a Prospective Study
AbstractPurposeThe present study purposed to investigate the effects of weight loss with LSG on echocardiographic parameters of diastolic dysfunction in subjects with morbid obesity.MethodsSixty-one subjects undergoing LSG for standard indications were enrolled. All subjects underwent a physical examination, electrocardiography, and transthoracic echocardiography before and 6  months after the LSG. Peak early diastolic velocity (E), deceleration time (DT), and peak late diastolic velocity (A) were measured from the transmitral flow signal. Peak early (e′) diastolic mitral annular velocity was measured at the two...
Source: Obesity Surgery - April 9, 2020 Category: Surgery Source Type: research

Metabolic Surgery Diabetes Remission (MDR) Score: a New Preoperative Scoring System for Predicting Type 2 Diabetes Remission at 1  Year After Metabolic Surgery in the Singapore Multi-ethnic Asian Setting
AbstractPurposeThe utility of available scoring systems for type 2 diabetes (T2D) remission prediction after metabolic surgery has not been defined in a multi-ethnic Asian population like Singapore. We sought to assess the predictive performance of the Asia-developed ABCD scoring system for T2D remission after metabolic surgery, and develop a new algorithm to improve prediction.Materials and MethodsWe conducted a retrospective analysis of adults with T2D who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy between 2007 and 2018, and followed for 1  year postoperatively (n = 114, mean age 4...
Source: Obesity Surgery - April 8, 2020 Category: Surgery Source Type: research

A medicolegal approach to the very rare Auto-Brewery (endogenous alcohol fermentation) syndrome.
Conclusion: Various gastrointestinal system abnormalities such as through laparotomy, gastrectomy are reported in most of Auto-Brewery syndrome cases. There are cases, although rare, where gastrointestinal disorders are not detected and secondary disorders of normal intestinal flora due to frequent antibiotic use seem to be a factor. Such a condition is present in the current case. Those who are aware of this condition may falsely rely on it as a method to avoid penalties. On the other hand, genuine patients suffering from this condition may be caught by traffic control and become victims of the condition. For that reason,...
Source: Traffic Injury Prevention - April 7, 2020 Category: Accident Prevention Authors: Akbaba M Tags: Traffic Inj Prev Source Type: research

Endoscopic internal drainage by double pigtail stents in the management of laparoscopic sleeve gastrectomy leaks
Leaks and fistulas after laparoscopic sleeve gastrectomy (SG) are a major adverse event of bariatric surgery. Endoscopic management for post SG leaks has evolved from closure with covered self-expanding metallic stents (SEMS) to endoscopic internal drainage (EID). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - April 6, 2020 Category: Surgery Authors: Iqbal Siddique, Waleed Alazmi, Salman K. Al-Sabah Tags: Original articles Source Type: research

Weight Loss After Bariatric Surgery in Morbidly Obese End-Stage Kidney Disease Patients as Preparation for Kidney Transplantation. Matched Pair Analysis in a High-Volume Bariatric and Transplant Center
ConclusionMorbidly obese ESKD patients have an equal weight loss to patients without ESKD. Bariatric surgery could improve access to kidney transplantation and may potentially improve transplantation outcomes of obese patients with ESKD. (Source: Obesity Surgery)
Source: Obesity Surgery - April 5, 2020 Category: Surgery Source Type: research

Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus. PMID: 32242546 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Modified laparoscopic Sleeve Gastrectomy with Rossetti anti-reflux fundoplication. Results after 220 procedures with 24 months follow-up
Gastroesophageal Reflux Disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Laparoscopic Sleeve Gastrectomy (LSG) is one of the most frequently performed bariatric procedures. The relationship between LSG and GERD has gained increasing attention. This retrospective study aims to assess the effectiveness of combined LSG and modified Rossetti anti-reflux fundoplication for the treatment of GERD on morbidly obese patients after bariatric surgery. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - April 4, 2020 Category: Surgery Authors: Stefano Olmi, Matteo Uccelli, Giovanni Carlo Cesana, Francesca Ciccarese, Alberto Oldani, Riccardo Giorgi, Stefano Maria De Carli, Roberta Villa, Adelinda Angela Giulia Zanoni, Marta Bonaldi Tags: Original articles Source Type: research

Increased gallstone formation after sleeve gastrectomy and the preventive role of ursodeoxycholic acid.
Conclusions: Stone or sludge development in the gallbladder due to rapid weight loss after obesity surgery is quite common. However, we observed that the gallstone development decreased significantly with the prophylactic use of UDCA in patients who had undergone obesity surgery. PMID: 32233269 [PubMed - in process] (Source: Acta Gastro-Enterologica Belgica)
Source: Acta Gastro-Enterologica Belgica - April 3, 2020 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research

Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study
AbstractIntroductionBone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.Design and MethodsAn observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4  years. Calciotropic hormones were also measured.ResultsForty-seven patients un...
Source: Obesity Surgery - April 3, 2020 Category: Surgery Source Type: research

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
ConclusionsSuper morbidly obese patients required fewer opioids and analgesics perioperatively. They exhibited higher comorbidities with greater anaesthesia time and ICU admissions. PACU stay time and pain scores were comparable. (Source: Obesity Surgery)
Source: Obesity Surgery - April 3, 2020 Category: Surgery Source Type: research

A case of advanced gastric cancer showing HER2 positivity after chemotherapy
AbstractA 63-year-old man had advanced poorly differentiated gastric adenocarcinoma with para-aortic lymph node metastases. No HER2 expression was observed in four endoscopic biopsies from the primary tumor. Tumors shrunk after S-1 with cisplatin treatment, and he underwent simple gastrectomy due to stenosis. Interestingly, HER2 diffusely overexpressed in the resected surgical specimen. His disease was stable with trastuzumab-containing therapy for 6.4  months. This case may suggest a selection of HER2-positive cells that were insensitive to the chemotherapy, and further study is needed for the change of intratumoral ...
Source: International Cancer Conference Journal - April 3, 2020 Category: Cancer & Oncology Source Type: research

Near-infrared fluorescence-guided surgery using indocyanine green facilitates secure infrapyloric lymph node dissection during laparoscopic distal gastrectomy
This study enrolled patients with early gastric cancer scheduled for laparoscopic distal gastrectomy. After intraoperative submucosal injection of ICG (0.1  mg/mL), LN dissection was conducted under near-infrared ICG fluorescence guidance. The operation time, bleeding events during infrapyloric LN dissection were analyzed. Cases were retrospectively 1:3 propensity-score matched to patients who underwent laparoscopic distal gastrectomy without ICG inje ction.ResultsThe mean time from midline omentectomy to exposure of the right gastroepiploic vein was significantly shorter in the ICG group (n = 20) than i...
Source: Surgery Today - April 3, 2020 Category: Surgery Source Type: research

Laparoscopic-guided transversus abdominis plane block following laparoscopic sleeve gastrectomy is associated with an earlier return to activity: a study of 271 patients
In this study, we examined the effect of laparoscopic-guided transversus abdominis plane block (LG TAP) for further optimizing multimodal pain control.MethodsThis is a retrospective analysis of a prospectively collected database of 140 consecutive patients undergoing LSG without TAP block (pre-TAP group) compared to 131 patients undergoing LSG with LGTAP (TAP group). All operations were performed laparoscopically utilizing uniform clinical pathways. Baseline characteristics for both groups were comparable. Both groups received standardized anesthesia. Outcomes included time to postoperative ambulation, pain scores, PCA vol...
Source: Surgical Endoscopy - April 2, 2020 Category: Surgery Source Type: research

Short-term improvements in cognitive function following vertical sleeve gastrectomy and Roux-en Y gastric bypass: a direct comparison study
ConclusionsThis is the first report of cognitive improvements following VSG and the first direct comparison of cognitive improvements following RYGB and VSG. Short-term improvements in specific domains of cognitive function are observed at the beginning of the active weight loss phase following bariatric surgery that persisted to 3  months. The anatomical distinction between the two surgeries and resulting differential metabolic profiles may be responsible for the improvements in attention observed following RYGB but not following VSG. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 2, 2020 Category: Surgery Source Type: research

Reduction of opioid use after implementation of enhanced recovery after bariatric surgery (ERABS)
AbstractBackgroundEnhanced recovery after surgery (ERAS) protocols have been extensively proven in lower gastrointestinal surgery to decrease postoperative physiologic stress and length of stay (LOS). ERAS in bariatric surgery (ERABS) varies immensely from each program with inconsistent results with a predominant goal of reducing LOS. Our focus in implementing enhanced recovery after bariatric surgery (ERABS) protocols is aimed at reducing postoperative pain and opioid use.MethodsThis is a retrospective review of patients who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (VSG) at a single hig...
Source: Surgical Endoscopy - April 2, 2020 Category: Surgery Source Type: research

Reduced anastomotic complications with intracorporeal esophagojejunostomy using endoscopic linear staplers (overlap method) in laparoscopic total gastrectomy for gastric carcinoma
ConclusionsIntracorporeal anastomosis using linear staplers reduced anastomotic bleeding and stenosis compared to extracorporeal anastomosis after LTG. Future research will be required to determine the ideal method for intracorporeal anastomosis in LTG. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 2, 2020 Category: Surgery Source Type: research

Usefulness of endoscopic metal stent placement for malignant afferent loop obstruction
ConclusionsThe success rate of EMSP for mALO was high in patients with poor general conditions due to advanced-stage malignant tumors and it was able to be safely performed, suggesting its high clinical efficacy. The incidence of mALO recurrence after EMSP was low. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 2, 2020 Category: Surgery Source Type: research

Single Versus Double-Anastomosis Duodenal Switch: Single-Site Comparative Cohort Study in 440 Consecutive Patients
AbstractPurposeTo study weight loss, comorbidity remission, complications, and nutritional deficits after duodenal switch (DS) and single-anastomosis DS with sleeve gastrectomy (SADI-S).Material and MethodsRetrospective review of patients submitted to DS or SADI-S for morbid obesity in a single university hospital.ResultsFour hundred forty patients underwent DS (n = 259) or SADI-S (n = 181). Mean preoperative body mass index (BMI) was 50.8 ± 6.4Kg/m2. Mean follow-up was 56.1  ± 37.2 months for DS and 27.2 ± 18.9 months for ...
Source: Obesity Surgery - April 2, 2020 Category: Surgery Source Type: research

Relationship between neuropilin-1 expression and prognosis, according to gastric cancer histology
AbstractNeuropilin-1 (NRP-1) is known to be related to various types of cancer and is considered a novel tumor marker or therapeutic target. The aim of this study was to identify the clinical implications of NRP-1 expression in terms of prognosis in patients with gastric cancer. A total of 265 patients who underwent radical gastrectomy for the treatment of gastric cancer from 2008 to 2011 were included in this retrospective study. NRP-1 expression of tumors was determined by immunohistochemistry. The patients ’ clinicopathological characteristics, operative details, and long-term outcomes were retrospectively analyze...
Source: Journal of Molecular Histology - April 2, 2020 Category: Laboratory Medicine Source Type: research

Facilitated completion of 1-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer by medical oncologists
ConclusionsMedical oncologists may facilitate completion of adjuvant S-1 monotherapy. (Source: Surgery Today)
Source: Surgery Today - April 2, 2020 Category: Surgery Source Type: research

Potential Therapeutic Approaches for the Intussusception Through a Side-to-Side Jejunojejunal Anastomosis After Laparoscopic Gastrectomy
We reviewed our experience with the management of intussusception presenting as a complication of laparoscopic gastrectomy (LG) and studied the feasibility of a laparoscopic intervention to treat or prevent this condition. We retrospectively analyzed the data of 12 patients diagnosed with intussusception, following gastrectomy, from 2008 to 2017, including clinical manifestations, incidence, post-LG time-interval before diagnosis, and treatment. Totally, 12/2300 gastrectomy patients (0.52%) developed intussusception. All 12 had undergone laparoscopic distal gastrectomy for gastric cancer (12/1250, 0.96%) and presented with...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - April 1, 2020 Category: Surgery Tags: Original Articles Source Type: research

The First Report of Laparoscopic Multivisceral Resection for a Gastrocolic Fistula Secondary to Colon Cancer
Conclusion: Laparoscopic multivisceral en bloc R0 resection of locally advanced colon cancer with gastrocolic fistula can be accomplished safely in experienced hands. (Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques)
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - April 1, 2020 Category: Surgery Tags: Online Articles: Technical Reports Source Type: research

Laparoscopic distal gastrectomy (with preservation of left hepatic artery) (with video)
Publication date: Available online 30 March 2020Source: Journal of Visceral SurgeryAuthor(s): A. Zarzavadjian Le Bian, L. Genser, P. Wind (Source: Journal of Visceral Surgery)
Source: Journal of Visceral Surgery - April 1, 2020 Category: Surgery Source Type: research

Use of Antihypertensive Medications in Left Ventricular Assist Device Patients Who Undergo Sleeve Gastrectomy
The use of antihypertensive medications has been shown to significantly decrease in most morbidly obese patients who undergo sleeve gastrectomy (SG) surgery, with 58% of patients having complete resolution of their hypertension. It is unknown if this same effect is seen in morbidly obese patients with left ventricular assist devices (LVAD) who undergo SG. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: M. Jumean, A. Patel, S. Nathan, S. Kumar, M. Akay, I. Salas de Armas, M. Patel, K. Rajagopal, R. Radovancevic, I. Gregoric, B. Kar Tags: (866) Source Type: research

Post-Transplant Survival of Morbidly Obese LVAD Patients Undergoing Bariatric Surgery
Patients with left ventricular assist devices (LVADs) who are morbidly obese cannot be easily bridged to heart transplantation (HT). Reported UNOS data show that the survival rate of such patients was low after HT. Some patients are obese at the time of LVAD implantation, whereas others become morbidly obese following LVAD implantation. We applied laparoscopic sleeve gastrectomy (LSG) as a treatment strategy and our study looked to determine its efficacy and safety. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: M. Akay, M. Alagoz, M. Ng, I.A. Salas de Armas, M.K. Jezovnik, M.K. Patel, K. Rajagopal, S. Kumar, M. Jumean, B.H. Akkanti, R. Radovancevic, S. Shah, K.S. Bajwa, B. Kar, I.D. Gregoric Tags: (835) Source Type: research

A Woman With an Intrauterine and an Extrauterine Intrauterine Device
A 44-year-old woman with a history of hypertension and partial gastrectomy presented to the emergency department with low thoracic back pain of 2  days' duration without red flag symptoms. The physical examination was significant for point tenderness to palpation in the lower thoracic spine without overlying skin changes or neurologic symptoms. Considering her large body habitus and history of gastrectomy, a thoracic radiograph was obtained to rule out compression fracture due to osteoporosis (Figure 1). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - April 1, 2020 Category: Emergency Medicine Authors: Brian S. Shin, Ryan Giorgetti, Laura D. Melville Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Roux-en-Y Gastric Bypass or Sleeve Gastrectomy for Type 2 Diabetes: Expanding Role of Individualized Metabolic Surgery (IMS) Score
As recently summarized1, there are only four randomized clinical trials (RCTs) in patients with type 2 diabetes mellitus (T2DM) comparing Roux-en-Y gastric bypass (RYGB) with sleeve gastrectomy (SG) and providing level I evidence up to 5 years after randomization.2-5 None of the individual studies were primarily designed and adequately powered to compare the effects of RYGB with SG on T2DM. However, combined analysis of these RCTs (i.e. meta-analysis) in order to increase the sample size and statistical power (RYGB, n=176 versus SG, n=175) would indicate that either there is no significant long-term difference between RYGB...
Source: Surgery for Obesity and Related Diseases - April 1, 2020 Category: Surgery Authors: Ali Aminian Tags: Letter to the Editor Source Type: research

Intraductal papillary neoplasm in common bile duct opening into the stomach
ConclusionEctopic biliary drainage into the stomach is extremely rare, but its recognition may help identify the cause of certain clinical conditions and prevent bile duct injury during surgery if required. (Source: Surgical Practice)
Source: Surgical Practice - April 1, 2020 Category: Surgery Authors: Victoria Cindy Lai, Eric C.H. Lai, Chung Ngai Tang Tags: ORIGINAL ARTICLE Source Type: research

Lymphatic leakage after laparoscopic sleeve gastrectomy; presentation, management and review of the literature.
We report the first case of lymphatic leakage after sleeve gastrectomy, which was treated with conservative treatment. PMID: 32233848 [PubMed - as supplied by publisher] (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 1, 2020 Category: Surgery Authors: Bora Makal G Tags: Ann R Coll Surg Engl Source Type: research

Prevention of Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy: Are We Doing Enough?
Abstract The worldwide obesity epidemic has led to an increase in the number of bariatric procedures for treatment. Currently, the most commonly performed bariatric surgical operation in the United States is the laparoscopic sleeve gastrectomy (LSG). The risk of postoperative nausea and vomiting (PONV) is exceptionally high following the LSG: as much as 65%. Anesthesia providers should be mindful of this elevated risk and stay up to date on evidence-based techniques that help to mitigate the incidence of PONV related to this specific procedure. The purposes of this clinical review are to increase provider awarenes...
Source: AANA Journal - April 1, 2020 Category: Anesthesiology Authors: Varner KL, March AL Tags: AANA J Source Type: research

Cholelithiasis After Sleeve Gastrectomy and Effectiveness of Ursodeoxycholic Acid Treatment
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - March 31, 2020 Category: Surgery Authors: Ozan Şen Ahmet G ökhan Türkçapar Mehmet Ali Yerdel Source Type: research

Cholelithiasis After Sleeve Gastrectomy and Effectiveness of Ursodeoxycholic Acid Treatment
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - March 31, 2020 Category: Surgery Authors: Ozan Şen Ahmet G ökhan Türkçapar Mehmet Ali Yerdel Source Type: research

Degeneration of Barrett's Esophagus after Sleeve Gastrectomy.
PMID: 32245574 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - March 31, 2020 Category: Surgery Authors: Lucas Guerrero V, Luna A, Rebasa P, Montmany S, Navarro S Tags: Cir Esp Source Type: research

Gastric bypass but not sleeve gastrectomy increases risk of major osteoporotic fracture: French population ‐based cohort study
ConclusionsIn patients aged 40 ‐65, gastric bypass but not sleeve gastrectomy or the other procedures increased risk of major osteoporotic fractures.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Julien Paccou, Niels Martign ène, Eric Lespessailles, Evgéniya Babykina, François Pattou, Bernard Cortet, Grégoire Ficheur Tags: Original Article Source Type: research

Laparoscopic Versus Open D2 Gastrectomy for Gastric Cancer: A Case-Matched Comparative Study
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - March 30, 2020 Category: Surgery Authors: Basil J. Ammori Huthaifa Asmer Hani Al-Najjar Hebah Al-Bakri Ali Dabous Faiez Daoud Mahmoud Almasri Source Type: research

Letter in Reply: Long-term Results After Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: Five-Year Follow-up
(Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - March 30, 2020 Category: Surgery Source Type: research

Laparoscopic Versus Open D2 Gastrectomy for Gastric Cancer: A Case-Matched Comparative Study
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - March 30, 2020 Category: Surgery Authors: Basil J. Ammori Huthaifa Asmer Hani Al-Najjar Hebah Al-Bakri Ali Dabous Faiez Daoud Mahmoud Almasri Source Type: research

Primary lung squamous cell carcinoma and its association with gastric metastasis: A case report and literature review
AbstractNearly 50% of primary lung carcinoma patients present with distant metastasis at their first visit. However, gastrointestinal tract (GIT) metastasis is an infrequent impediment. Herein, we report a case of progressive dysphagia and epigastralgia as an initial manifestation of recurrence as gastric metastasis of primary lung squamous cell carcinoma (SCC) after curative surgery. A 64 ‐year‐old man was diagnosed with primary lung SCC of the right lower lobe, and underwent thoracoscopic lower lobectomy. One year after lobectomy, computed tomography (CT) scan showed a gastric fundal mass located in the gastric cardi...
Source: Thoracic Cancer - March 26, 2020 Category: Cancer & Oncology Authors: Mariko Nemoto, Pankaj Prasoon, Hiroshi Ichikawa, Takaaki Hanyu, Yosuke Kano, Yusuke Muneoka, Kenji Usui, Yuki Hirose, Kohei Miura, Yoshifumi Shimada, Masayuki Nagahashi, Jun Sakata, Takashi Ishikawa, Masanori Tsuchida, Toshifumi Wakai Tags: CASE REPORT Source Type: research

Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence
AbstractBackgroundMetabolomics is useful for analyzing the nutrients necessary for cancer progression, as the proliferation is regulated by available nutrients. We studied the metabolomic profile of gastric cancer (GC) tissue to elucidate the associations between metabolism and recurrence.MethodsCancer and adjacent non-cancerous tissues were obtained in a pair-wise manner from 140 patients with GC who underwent gastrectomy. Frozen tissues were homogenized and analyzed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Metabolites were further assessed based on the presence or absence of recurrence.Re...
Source: Gastric Cancer - March 26, 2020 Category: Gastroenterology Source Type: research

Prognostic Significance of Lymphatic, Venous and Perineural Invasion After Neoadjuvant Chemotherapy in Patients with Gastric Adenocarcinoma.
Abstract BACKGROUND: The significance of perineural (PNI), lymphatic (LI) and venous invasion (VI) in gastric cancer patients who have received neoadjuvant chemotherapy is unclear. The aim of this study is to determine the incidence and prognostic significance of LI, VI and PNI in these patients. PATIENTS AND METHODS: Consecutive patients treated with neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy were reviewed. Presence of LI, VI and PNI was recorded and correlated with clinical outcomes. RESULTS: A total of 243 patients underwent gastrectomy after neoadjuvant therapy for gastr...
Source: Ann Oncol - March 26, 2020 Category: Cancer & Oncology Authors: Woodham BL, Chmelo J, Donohoe CL, Madhavan A, Phillips AW Tags: Ann Surg Oncol Source Type: research

Optimizing bariatric surgery outcomes: a novel preoperative protocol in a bariatric population with gastroesophageal reflux disease
ConclusionsForegut pathology is common in bariatric patients with subjective symptoms of GERD. Implementing a comprehensive protocol to objectively assess these patients leads to a significant clinical impact on which procedure these patients ultimately undergo. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 24, 2020 Category: Surgery Source Type: research

Determining changes in bone metabolism after bariatric surgery in postmenopausal women
AbstractBackgroundAccelerated bone loss is a known complication after bariatric surgery. Bone mineral density has been shown to decrease significantly after Laparoscopic Roux-en-Y gastric bypass (RYGB). Laparoscopic sleeve gastrectomy (SG) effects on bone density are largely unknown. This should be considered for those with increased preoperative risk for bone loss, such as postmenopausal females.MethodsThis prospective clinical trial included postmenopausal patients, with BMI  ≥ 35 k/m2, being evaluated for either RYGB or SG. Patients with history of osteoporosis, estrogen hormone replacement therapy...
Source: Surgical Endoscopy - March 24, 2020 Category: Surgery Source Type: research

The first consensus statement on revisional bariatric surgery using a modified Delphi approach
ConclusionExperts achieved consensus on a number of aspects of RBS. Though expert opinion can only be regarded as low-quality evidence, the findings of this exercise should help improve the outcomes of RBS while we develop robust evidence to inform future practice. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 24, 2020 Category: Surgery Source Type: research

Predicting surgical site infections following laparoscopic bariatric surgery: development of the BariWound tool using the MBSAQIP database
This study included patients who underwent primary laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG). The primary outcome of interest was incisional SSI occurring within 30  days. Surgeries performed in 2015 were used in a derivation cohort and the predictive tool was validated against the 2016 cohort. A forward selection algorithm was used to build a logistic regression model predicting probability of SSI.ResultsA total of 274,187 patients were included with 71.7% being LSG and 28.3% LRYGB. 0.7% of patients had a SSI in which 71.0% had an incisional SSI, and 29.9% had an organ/spa...
Source: Surgical Endoscopy - March 24, 2020 Category: Surgery Source Type: research

Surgeon variation in severity of reflux symptoms after sleeve gastrectomy
ConclusionsWe found that 1/3 of patients had worsening symptoms of reflux after LSG and that severity of symptoms varied. Surgeons with the highest rates of worsening reflux had similar operative experience and complication rates than those with the lowest. Further assessment of operative technique and skill may be informative. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 24, 2020 Category: Surgery Source Type: research

Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
Objective: We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG).Design: Retrospective cohort study.Setting: Single tertiary care academic referral center.Participants: One hundred fifty adolescent (≤ 21-years) and adult (>21-years) subjects with severe obesity between 15 and 70 years of age who underwent RYGB or SG.Outcomes: Metabolic parameters, weight and height measures were obtained pre-and post-surgery (at 3 and 6 months, and then annually for 4 years).Results: Median pre-surgical body mass index (BM...
Source: Frontiers in Endocrinology - March 24, 2020 Category: Endocrinology Source Type: research

Is splenectomy for dissecting splenic hilar lymph nodes justified for scirrhous gastric cancer?
ConclusionThe metastatic rate of the splenic hilar lymph nodes was relatively high, and the therapeutic index was the sixth highest among the 15 regional lymph nodes included in D2 dissection. Splenectomy for dissecting splenic hilar lymph nodes would be justified for scirrhous gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - March 24, 2020 Category: Gastroenterology Source Type: research

Hospital Length of Stay after Metabolic and Bariatric Surgery by Race/Ethnicity and Procedure Type among Florida Patients.
We examined the association of hospital length of stay (LOS) by race-ethnicity (Hispanic, non-Hispanic white [NHW], NH black [NHB]) and MBS-procedure among Florida inpatients. DESIGN: Secondary analysis of inpatient records was performed using the 2016 Florida Agency for Health Care Administrative (AHCA) data. Records of Laparoscopic Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Adjustable Gastric Banding (LAGB), and Sleeve Gastrectomy (SG) procedures based on ICD 10th edition code were analyzed. Via logistic regression analysis, the adjusted odds ratio (aOR) of longer LOS (≥2 versus 
Source: Journal of the National Medical Association - March 23, 2020 Category: General Medicine Tags: J Natl Med Assoc Source Type: research

Correction to: Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?
In the original publication of this article [1] there are two garbled codes in the second sentence, the fourth paragraph of the Background section. The correct sentence should be: Tumor growth leads to the increased production of inflammatory cytokines and growth factors (mainly IL-1, IL-3, IL-6, IL-11, IL-23, and TNF-), and this perpetual process ensures immortality. These promoting factors are also important for angiogenesis and hematopoiesis, which explains the increase in blood cell types in cancerous diseases. The original publication has been corrected. (Source: Military Medical Research)
Source: Military Medical Research - March 23, 2020 Category: International Medicine & Public Health Source Type: research

Non-robotic minimally invasive gastrectomy as an independent risk factor for postoperative intra-abdominal infectious complications: A single-center, retrospective and propensity score-matched analysis.
CONCLUSION: The findings showed that robotic surgery might improve short-term outcomes following minimally invasive radical gastrectomy by reducing intra-abdominal infectious complications. PMID: 32231421 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2020 Category: Gastroenterology Authors: Shibasaki S, Suda K, Nakauchi M, Nakamura K, Kikuchi K, Inaba K, Uyama I Tags: World J Gastroenterol Source Type: research