Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer.
Abstract OBJECTIVES: To evaluate the prognostic significance of lymphovascular invasion (LVI) for patients with gastric cancer (GC). METHODS: A total of 1,720 consecutive patients who underwent curative gastrectomy were retrospectively identified. The association between LVI and clinicopathologic characteristics was determined and its impact on survival outcome was evaluated. RESULTS: LVI was detected in 21.3% of GC patients, 5.9% of patients with early GC, 24.0% of patients with advanced GC, and 6.7% of node-negative patients using H&E staining. Tumor size (odds ratio [OR], 1.509; 95% confidence int...
Source: American Journal of Clinical Pathology - March 8, 2020 Category: Pathology Authors: Mei D, Zhao B, Zhang J, Luo R, Lu H, Xu H, Huang B Tags: Am J Clin Pathol Source Type: research

Recurrence of Cutaneous and Lymph Node Metastases 12 years after Radical Total Gastrectomy for Stage IIA Gastric Cancer: A Case Report.
Authors: Yasuda T, Hayashi S, Nakahata Y, Yasuda Y, Omatsu T, Obora A, Kojima T, Yagi N Abstract We herein report a rare case of cutaneous and lymph node metastases that recurred 12 years after radical total gastrectomy for stage IIA gastric cancer. A 62-year-old man had undergone total gastrectomy for stage IIA gastric cancer 12 years earlier without postoperative adjuvant chemotherapy. At 12 years after the surgery, he was admitted for left jugular swelling. Computed tomography revealed supraclavicular lymph node swelling and precordial subcutaneous edema. The lymph node specimens and cutaneous biopsies indicated...
Source: Internal Medicine - March 7, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Sleeve Gastrectomy and Anterior Fundoplication (D-SLEEVE) Prevents Gastroesophageal Reflux in Symptomatic GERD
ConclusionD-SLEEVE is an effective restrictive procedure, which recreates a functional LES pressure able to control and/or prevent mild GERD at 1-year follow-up. (Source: Obesity Surgery)
Source: Obesity Surgery - March 7, 2020 Category: Surgery Source Type: research

Automated Surgical Instrument Detection from Laparoscopic Gastrectomy Video Images Using an Open Source Convolutional Neural Network Platform
The common use of laparoscopic interventions produces impressive amounts of video data that are difficult to review for surgeons wishing to evaluate and improve their skills. Therefore, a need exists for the development of computer-based analysis of laparoscopic videos to accelerate surgical training and assessment. We developed a surgical instrument detection system for video recordings of laparoscopic gastrectomy procedures. This system, whose use may increase the efficiency of the video reviewing process, is based on the open source neural network platform, YOLOv3. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - March 7, 2020 Category: Surgery Authors: Yuta Yamazaki, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yuta Hiasa, Yoshito Otake, Yoshinobu Sato, Yoshihiro Kakeji Tags: Original Scientific Article Source Type: research

Comparison of surgical outcomes among different methods of esophagojejunostomy in laparoscopic total gastrectomy for clinical stage I proximal gastric cancer: results of a single-arm multicenter phase II clinical trial in Korea, KLASS 03
ConclusionsThe extracorporeal circular stapling and the intracorporeal linear stapling were safe and feasible in laparoscopic total gastrectomy, however, intracorporeal circular stapling increased EJ stenosis. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 6, 2020 Category: Surgery Source Type: research

Quality of Life After Curative Resection for Gastric Cancer: Survey Metrics and Implications of Surgical Technique
This article reviews the common psychometric surveys and preference-based measures used among patients following gastrectomy. It also provides an overview of studies that address associations between surgical decision-making and postoperative health-related QoL. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - March 6, 2020 Category: Surgery Authors: Yinin Hu, Victor M. Zaydfudim Tags: Oncology Source Type: research

Neuroanatomical changes in white and grey matter after sleeve gastrectomy
Publication date: Available online 4 March 2020Source: NeuroImageAuthor(s): Andréanne Michaud, Mahsa Dadar, Mélissa Pelletier, Yashar Zeighami, Isabel Garcia-Garcia, Sylvain Iceta, Yvonne Yau, Mélanie Nadeau, Simon Marceau, Laurent Biertho, André Tchernof, D. Louis Collins, Denis Richard, Alain Dagher (Source: NeuroImage)
Source: NeuroImage - March 5, 2020 Category: Neuroscience Source Type: research

Characteristics of morbid obese patients with high-risk cardiac disease undergoing laparoscopic sleeve gastrectomy surgery
Conclusion: Through this study, we can conclude that laparoscopic sleeve gastrectomy surgery can be considered a safe procedure. However, further studies with a large sample size and a more robust methodology are needed to build upon the findings of this study. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - March 5, 2020 Category: Anesthesiology Authors: Fahad BaMehriz Mohammed N Alali Hassan Arishi Faroq Abdulfattah Sarah Alhaizan Abdelazeem ElDawlatly Abdullah Aldohayan Source Type: research

Reply to the Letter to the Editor Concerning Anti-reflux Mucosectomy (ARMS) in Sleeve Gastrectomy Patients with GERD and Barrett ’s Esophagus
(Source: Obesity Surgery)
Source: Obesity Surgery - March 5, 2020 Category: Surgery Source Type: research

Letter to the Editor: “Long-Term Results after Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: 5-Year Follow-up”
(Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - March 5, 2020 Category: Surgery Source Type: research

Enhanced recovery after bariatric surgery: Implementation of program and clinical outcomes from a bariatric surgery and metabolic diseases reference center.
Conclusion: Applying ERABS protocols is feasible, safe, morbidity low, LOS acceptable, and a low readmission rate within 30 days. PMID: 32116322 [PubMed - in process] (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 4, 2020 Category: Surgery Authors: Gálvez-Gallo G, Plascencia-Posada FJ, Cárdenas-Figueroa JA, Gutiérrez-Álvarez G, Gutiérrez-Gómez JA, Gallardo-Vázquez CA Tags: Cir Cir Source Type: research

Comparing the 5-Year Diabetes Outcomes of Sleeve Gastrectomy and Gastric Bypass
This cohort study evaluates associations of sleeve gastrectomy and Roux-en-Y gastric bypass bariatric surgery with type 2 diabetes outcomes in adult patients. (Source: JAMA Surgery)
Source: JAMA Surgery - March 4, 2020 Category: Sports Medicine Source Type: research

Bariatric Surgery and Diabetes Treatment —Finding the Sweet Spot
Type 2 diabetes (T2DM) is closely associated with obesity. Given that weight loss is associated with T2DM remission, there has been intense interest in diabetes outcomes following bariatric surgery. The landmark Surgical Therapy and Medications Potentially Eradicate Diabetes Efficiently (STAMPEDE) trial found that bariatric surgery was a more effective diabetes treatment compared with medical management after 5 years of follow-up. While it was not adequately powered to detect differences between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), other randomized clinical trials have found no differences in diabet...
Source: JAMA Surgery - March 4, 2020 Category: Sports Medicine Source Type: research

A nodal diagnosis by computed tomography is unreliable for patients who need additional gastrectomy after endoscopic submucosal dissection
ConclusionsA nodal diagnosis by CT is unreliable for patients who need additional gastrectomy after ESD. (Source: Surgery Today)
Source: Surgery Today - March 4, 2020 Category: Surgery Source Type: research

Over-the-scope clip for anastomotic leak after total gastrectomy
Endoscopy DOI: 10.1055/a-1122-8086 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - March 4, 2020 Category: Gastroenterology Authors: Currais, Pedro M ão de Ferro, Susana Castela, Joana Dias Pereira, Ant ónio Tags: E-Videos Source Type: research

Risk-reducing total gastrectomy in asymptomatic CDH1 carriers
ConclusionRisk-reducing total gastrectomy remains the best clinical management for patients with hereditary diffuse gastric cancer harboring a  germline, pathogenicCDH1 variant. In our series, intramucosal carcinoma foci were found in the great majority (89.5%) ofCDH1 carriers. (Source: European Surgery)
Source: European Surgery - March 4, 2020 Category: Surgery Source Type: research

Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity That Underwent Bariatric Surgery
ConclusionsOur study postulates the IRT as a potential tool to evaluate BAT thermogenic activation in patients with obesity before and after a bariatric surgery. Further studies are needed to evaluate differences between LSG technique and RYGB on BAT activation. (Source: Obesity Surgery)
Source: Obesity Surgery - March 4, 2020 Category: Surgery Source Type: research

Impact of Postprandial Hypoglycemia on Weight Loss After Bariatric Surgery
ConclusionsMild-to-moderate PPHG is a frequent complication after bariatric surgery and results in smaller weight loss after 2  years. Age, baseline BMI, and an earlier glucose peak during OGTT predict PPHG after bariatric surgery. (Source: Obesity Surgery)
Source: Obesity Surgery - March 4, 2020 Category: Surgery Source Type: research

HIDA and Seek: Challenges of Scintigraphy to Diagnose Bile Reflux Post-Bariatric Surgery
ConclusionA tailored HIDA scan protocol with addition of a SPECT-CT scan, ingestion of a fatty meal and prolonged scanning duration results in enhanced bile reflux detection in post-bariatric surgical patients. (Source: Obesity Surgery)
Source: Obesity Surgery - March 4, 2020 Category: Surgery Source Type: research

Assessment of education effects on patient involvement and bariatric treatment outcome: an observational study.
Authors: Sierżantowicz R, Ładny JR, Lewko J, Hady HR Abstract Introduction: As a result of the growing number of people with obesity, the popularity of bariatric surgery has been systematically increasing. It has not yet been explored whether individual education of the patient can contribute to long-term success in weight reduction after bariatric treatment. Aim: To implement and compare the effects of different education methods, versus receiving one-time written information in the form of a guidebook, on patient involvement in abiding by lifestyle recommendations after laparoscopic sleeve gastrectomy (LSG)...
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Gender-related metabolic outcomes of laparoscopic sleeve gastrectomy in 6-month follow-up.
Authors: Groth D, Woźniewska P, Olszewska M, Zabielski P, Ładny JR, Dadan J, Zalewska A, Błachnio-Zabielska A, Diemieszczyk I, Krętowski A, Hady HR Abstract Introduction: Laparoscopic sleeve gastrectomy (LSG) is recently a leading method in surgical treatment of morbid obesity. The metabolic outcome of intervention may be a result of many factors such as age, gender, preoperative weight loss and dietary restrictions. Aim: To evaluate gender-related differences in the results of LSG in 6-month follow-up. Material and methods: The study included 101 patients who underwent LSG at the University Clinical Ho...
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Laparoscopic sleeve gastrectomy: a study of efficiency in treatment of metabolic syndrome components, comorbidities and influence on certain biochemical markers.
Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers. PMID: 32117497 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Outcomes of laparoscopic sleeve gastrectomy by means of esophageal manometry and pH-metry, before and after surgery.
Conclusions: The LSG was found to cause a reduction in LESP, and an increase in acid reflux causing an extended relaxation time of the LES. This was confirmed by the increase seen in the DeMeester score. PMID: 32117496 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Outcomes of sleeve gastrectomy in patients older than 60 years: a multicenter matched case-control study.
Conclusions: Better weight loss is achieved in younger than in older patients, while maintaining a similar effect on the risk of complications and improvement in comorbidities. Therefore, SG is safe and effective in older people. PMID: 32117495 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Laparoscopic D2 plus complete mesogastrium excision using the "enjoyable space" approach versus conventional D2 total gastrectomy for local advanced gastric cancer: short-term outcomes.
Conclusions: The "enjoyable space" approach is an option to achieve D2 + CME, and its safety and feasibility over conventional method are confirmed with lower intraoperative blood loss and more harvested LNs. PMID: 32117487 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - March 3, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

A Simple Approach for Splenic Hilar Lymphadenectomy During Laparoscopic Total Gastrectomy for Advanced Gastric Cancer: the SHINY (Splenic HIlar Node dissection after total gastrectomY) Maneuver
(Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - March 3, 2020 Category: Surgery Source Type: research

Extraction bags provide no benefit when compared to unprotected lateral stomach extraction during laparoscopic sleeve gastrectomy
Publication date: Available online 29 February 2020Source: The American Journal of SurgeryAuthor(s): John Kuckelman, Varinia Vigueras, Dom Forte, Jason Bingham, James Sebesta, Matthew Eckert (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - March 2, 2020 Category: Surgery Source Type: research

Preoperative restrictive pulmonary dysfunction influences the survival after gastrectomy for elderly patients with gastric carcinoma
AbstractPurposeWe aimed to evaluate the prognostic impact of pulmonary dysfunctions and their relationships with other possible prognostic factors, especially sarcopenia, in elderly patients with gastric carcinoma (GC).MethodsIn total, 402 elderly GC patients ( ≥ 75 years) who underwent radical gastrectomy were retrospectively reviewed. Restrictive and obstructive pulmonary dysfunction were defined as %VC 
Source: Surgery Today - March 2, 2020 Category: Surgery Source Type: research

Internal Hernia Following Primary Laparoscopic SADI-S: the First Reported Case
ConclusionsAn internal hernia following LSADI-S is rare, despite the unclosed space behind the small bowel mesentery. If they occur, they should not cause ischemia and can be fixed easily using a laparoscopic surgical approach with good postoperative outcomes. (Source: Obesity Surgery)
Source: Obesity Surgery - March 2, 2020 Category: Surgery Source Type: research

Alterations of Serum Uric Acid Level and Gut Microbiota After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in a Hyperuricemic Rat Model
The objective of this study was to observe alterations of serum uric acid (SUA) level and gut microbiota after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery in a hyperuricemic rat model.MethodWe performed Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery in a hyperuricemic rat model. Serum uric acid (UA), xanthine oxidase (XO) activity, IL-6, TNF- α and lipopolysaccharide (LPS) level changes, and 16S rDNA of gut microbiota were analyzed.ResultsAfter the surgery, the RYGB and SG procedures significantly reduced body weight, serum UA, IL-6, TNF- α and LPS levels, and XO act...
Source: Obesity Surgery - March 2, 2020 Category: Surgery Source Type: research

Feasibility of Postoperative Home Monitoring Using Video Consultation and Vital Sign Monitoring of Bariatric Patients
ConclusionOur first experience with home monitoring was disappointing since home monitoring of vital signs had poor compliance and not all patients were able to use the application. Further refinement of the home monitoring tool is needed to increase compliance and utility of the tool. (Source: Obesity Surgery)
Source: Obesity Surgery - March 2, 2020 Category: Surgery Source Type: research

Effects of Laparoscopic Sleeve Gastrectomy on Non-Alcoholic Steatohepatitis and Liver Fibrosis in Japanese Patients with Severe Obesity
AbstractBackgroundThe prevalence of non-alcoholic steatohepatitis (NASH) in Japanese patients with severe obesity is extremely high. The aim of the present study was to evaluate the metabolic and histological effects of laparoscopic sleeve gastrectomy (LSG) on NASH and liver fibrosis in Japanese patients with severe obesity.MethodsBetween June 2008 and March 2019, all 79 patients with severe obesity who underwent LSG were included in the study. Sixty-eight patients had an intraoperative liver biopsy performed at the time of LSG. Ultrasound-guided liver biopsies were performed in patients with fibrosis at 12  months af...
Source: Obesity Surgery - March 2, 2020 Category: Surgery Source Type: research

Determinants of High Parathyroid Hormone Levels in Patients With Severe Obesity and Their Relationship With the Cardiometabolic Risk Factors, Before and After a Laparoscopic Sleeve Gastrectomy Intervention
ConclusionsOur results suggest that vitamin D deficiency is not the sole determinant of hyperparathyroidism in severe obesity because visceral fat deposition and leptin could both play a role. Obesity-related hyperparathyroidism is associated with insulin resistance and atherosclerosis, although the results from previous studies were conflicting. Finally, LSG intervention does not negatively affect vitamin D status and improves hyperparathyroidism. (Source: Obesity Surgery)
Source: Obesity Surgery - March 2, 2020 Category: Surgery Source Type: research

Reversal of Endoscopic Sleeve Gastroplasty and Conversion to Sleeve Gastrectomy – Two Case Reports
Publication date: Available online 29 February 2020Source: International Journal of Surgery Case ReportsAuthor(s): Qiuye Cheng, Kevin Tree, Michael Edye, Michael Devadas (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - March 1, 2020 Category: Surgery Source Type: research

Emergency Department Care of the Post-Metabolic and Bariatric Surgery Patient
This article will examine the specifics of each procedure along with the complications associated with any metabolic or bariatric surgery. Complications unique to each operation will be reviewed as well as recommendations for the management of these patients. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - March 1, 2020 Category: Emergency Medicine Tags: CME Review Article Source Type: research

Preoperative prealbumin levels on admission as an independent predictive factor in patients with gastric cancer
Background: To explore the role of preoperative prealbumin levels in predicting the prognosis of patients with gastric cancer. Methods: A total of 989 gastric cancer patients in the Affiliated Tumour Hospital of Harbin Medical University who underwent gastrectomy were included in this retrospective study. The preoperative prealbumin level, clinicopathological data, and follow-up data were recorded. According to the maximum chi-square survival correlation value, the survival of patients with low preoperative prealbumin ( (Source: Medicine)
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Measured versus Estimated Blood Loss: Interim Analysis of a Prospective Quality Improvement Study.
In conclusion, surgeons significantly underestimate and anesthesiologists significantly overestimate EBL. This finding impacts not only immediate patient care but also the interpretation of scoring systems relying on EBL. PMID: 32223802 [PubMed - in process] (Source: The American Surgeon)
Source: The American Surgeon - March 1, 2020 Category: Surgery Authors: Thomas S, Ghee L, Sill AM, Patel ST, Kowdley GC, Cunningham SC Tags: Am Surg Source Type: research

Does the preoperative platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio predict morbidity after gastrectomy for gastric cancer?
ConclusionBased on the results of the study, the PLR and NLR could be used as independent predictive factors for mortality and morbidity in patients with gastric cancer. (Source: Military Medical Research)
Source: Military Medical Research - February 29, 2020 Category: International Medicine & Public Health Source Type: research

Extraction bags provide no benefit when compared to unprotected lateral stomach extraction during laparoscopic sleeve gastrectomy
Currently, no evidence compares outcomes for techniques utilizing surgical specimen extractions bags versus unprotected extraction. (Source: American Journal of Surgery)
Source: American Journal of Surgery - February 29, 2020 Category: Surgery Authors: John Kuckelman, Varinia Vigueras, Dom Forte, Jason Bingham, James Sebesta, Matthew Eckert Source Type: research

Psychological Diagnoses and Weight Loss among Appalachian Bariatric Surgery Patients.
Conclusion: Other than baseline weight, BDI-II and BAI scores were not related to %EWL outcomes in patients receiving bariatric surgery in the Appalachian region. Future work should examine mixed methods approaches to capture prospective and longitudinal data to more thoroughly delve into mental health aspects of our Appalachian patients and improve efforts to recapture postoperative patients who may have been lost to follow-up. PMID: 32104600 [PubMed - in process] (Source: Journal of Obesity)
Source: Journal of Obesity - February 28, 2020 Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

Successful Conversion Surgery Following Chylous Ascites After Nivolumab for Advanced Gastric Cancer
Conclusion: Nivolumab has the potential to lead to R0 resection for patients with peritoneal carcinomatosis gastric cancer. To our knowledge, this is the first report of successful conversion surgery after nivolumab-related chylous ascites. (Source: In Vivo)
Source: In Vivo - February 28, 2020 Category: Research Authors: TOYOTA, S., ORITA, H., FUKUYAMA, Y., MOTOYOSHI, S., KAWANAMI, S., MAEDA, S., KURAMITSU, E., ICHIMANDA, M., NAGAMATSU, S., NAGATA, S., KAI, S., KORENAGA, D., MORI, M. Tags: Experimental Studies Source Type: research

Ribosomal DNA copy number is associated with P53 status and levels of heavy metals in gastrectomy specimens from gastric cancer patients.
This study was performed on paired tumor and adjacent normal tissues obtained from 65 gastric cancer patients who underwent gastrectomy. Immunohistochemistry was used to assess HER-2, E-cadherin, EGFR, CK (pan), CK20, CK7, TopoⅡ, CAM5.2, P53, and Ki-67 expression. Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the concentrations of 17 metals in gastric tissues. rDNA copy number was detected by qPCR in genomic DNA isolated from tissue samples. Associations between the expression of existing markers, metal concentrations, and rDNA copy number were evaluated. Within patients with gastric cancer, th...
Source: Environment International - February 28, 2020 Category: Environmental Health Authors: Feng L, Du J, Yao C, Jiang Z, Li T, Zhang Q, Guo X, Yu M, Xia H, Shi L, Jia J, Tong Y, Ju L, Liu J, Lou J, Lemos B Tags: Environ Int Source Type: research

Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type 2 diabetes mellitus: A systematic review and meta-analysis.
CONCLUSION: This study reports similar T2DM resolution rates by both LRYGB and LSG during 1-5 years of follow-up. However, long-term follow-up of 10 years is needed to further substantiate these findings. PMID: 32148383 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 28, 2020 Category: Gastroenterology Authors: Guraya SY, Strate T Tags: World J Gastroenterol Source Type: research

Is subtotal gastrectomy feasible for the treatment of gastric stump cancer located at the anastomotic site after distal gastrectomy for benign lesions?
Total gastrectomy (TG) is a widely accepted procedure for treating gastric stump cancer (GSC). However, subtotal gastrectomy (SG) would benefit elective patients with GSC. The aim of this study was to clarify ... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - February 27, 2020 Category: Cancer & Oncology Authors: Fuhai Ma, Yang Li, Weikun Li, Wenzhe Kang, Hao Liu, Shuai Ma, Bingzhi Wang, Yibin Xie, Yuxin Zhong, Yingtai Chen, Liyan Xue and Yantao Tian Tags: Research Source Type: research

Risk factors for stage underestimation in patients with clinical T1N0 gastric cancer
This study reviewed the medical records of 566 patients who underwent gastrectomy for clinical T1N0 gastric cancer.ResultsThe tumor stage was underestimated in 122 (21.6%) patients. The relapse-free survival rate was significantly lower in the patients with pathological stage II (P = 0.021) and III (P 
Source: Surgery Today - February 27, 2020 Category: Surgery Source Type: research

Indocyanine Green Tracer-Guided Lymph Node Dissection During Laparoscopic Gastrectomy
This randomized clinical trial investigates the safety and efficacy of using indocyanine green near-infrared tracer-guided imaging during laparoscopic D2 lymphadenectomy in patients with gastric cancer. (Source: JAMA Surgery)
Source: JAMA Surgery - February 26, 2020 Category: Sports Medicine Source Type: research

Development and internal validation of a diagnostic score for gastric linitis plastica
ConclusionIt is the first study validating a pre-therapeutic diagnostic score (Saint Louis linitis score) with an excellent ability to discriminate GLP from non-GLP adenocarcinomas. An external validation is necessary to confirm our data. (Source: Gastric Cancer)
Source: Gastric Cancer - February 26, 2020 Category: Gastroenterology Source Type: research

Technical details of and prognosis for the "China stitch", a novel technique for totally laparoscopic hand-sewn esophagojejunostomy.
In conclusion, the "China stitch", a novel hand-sewn technique, is a cost-effective, safe, and reliable method for esophagojejunostomy in totally laparoscopic total gastrectomy. PMID: 32092746 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - February 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Tolerability of early oral nutrition and factors predicting early oral nutrition failure after gastrectomy
This study aimed to investigate the tolerability of early oral nutrition and factors affecting early oral nutrition failure after gastrectomy. (Source: Clinical Nutrition)
Source: Clinical Nutrition - February 25, 2020 Category: Nutrition Authors: Aelee Jang, Oh Jeong Tags: Original article Source Type: research

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib.
In this study, we evaluated the effect of FDA-approved kinase inhibitors on GC. Through a combination of cell growth, migration and invasion assays, we identified dasatinib as an efficient inhibitor of GC proliferation. Mass-spectrometry-based selectivity profiling and subsequent knockdown experiments identified members of the SRC family of kinases including SRC, FRK, LYN and YES, as well as other kinases such as DDR1, ABL2, SIK2, RIPK2, EPHA2, and EPHB2 as dasatinib targets. The expression levels of the identified kinases were investigated on RNA and protein level in 200 classified tumor samples from patients, who had und...
Source: Oncotarget - February 22, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research