Fetal Alcohol Syndrome Disorder Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Secondary physical features in children with FASD
CONCLUSION: Secondary physical features were not more frequent in children with ARND compared to children without an FASD diagnosis but were a marker for lower cognitive function. The use of secondary physical features to support a diagnosis of ARND was not supported in this sample.PMID:38042254 | DOI:10.1016/j.ejmg.2023.104890 (Source: European Journal of Medical Genetics)
Source: European Journal of Medical Genetics - December 2, 2023 Category: Genetics & Stem Cells Authors: Miguel Del Campo Julie A Kable Claire D Coles Michael Suttie Christina D Chambers Gretchen Bandoli Source Type: research

Prenatal Exposure to Alcohol Not Linked to Accelerated Brain Aging, Study Shows
Exposure to alcohol in the womb is known to increase the risk of abnormal brain development and a range of cognitive and behavioral problems known as fetal alcohol spectrum disorders (FASD) in offspring. Astudy appearing inJAMA Network Open that compared the brains of a group of middle-aged people with and without FASD suggests that those with FASD are no more likely to experience accelerated brain aging in their 40s than those without FASD. While the study participants with FASD continued to exhibit alcohol-induced structural deficits in the brain and had observable behavioral symptoms as they did as young adult...
Source: Psychiatr News - November 21, 2023 Category: Psychiatry Tags: aging brain alcohol use during pregnancy brain development JAMA Network Open long-term brain health middle age MRI prenatal alcohol exposure Source Type: research

Questioning cognitive heterogeneity and intellectual functioning in fetal alcohol spectrum disorders from the Wechsler intelligence scale for children
Conclusion: Our results question the notion of WISC profile heterogeneity in FASD and point to working memory and processing speed over-impairment, with global repercussions but most often preserved elementary reasoning abilities.PMID:37974061 | DOI:10.1080/13854046.2023.2281703 (Source: The Clinical Neuropsychologist)
Source: The Clinical Neuropsychologist - November 17, 2023 Category: Psychiatry & Psychology Authors: Eliot Kerdreux Justine Fraize Pauline Garz ón Esther Chalain L éa Etchebarren Delphine Sitbon Anna Maruani Odile Boespflug-Tanguy Lucie Hertz-Pannier Marion Noulhiane Charlotte Pinabiaux David Germanaud Source Type: research

GSE202254 Peripheral RNA biomarkers for neurocognitive impairment shared by prenatal alcohol exposure (PAE) and offspring from mother with diabetes (OMD) in mice.
This study posits that AS of lymphocyte RNA is a rich resource, and deep-learning is an effective tool, for discovery of peripheral biomarkers of neurobehavioral deficits in children of diverse adverse pregnancies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression
CONCLUSIONS: Our findings suggest that heavy alcohol exposure during pregnancy can influence the proportion of fetal placental villi macrophages (Hofbauer cells) and increased expression of inflammatory genes. Future studies are needed to further characterize these effects and to assess the potential functional roles of placental inflammation in FASD.PMID:37918548 | DOI:10.1016/j.gene.2023.147951 (Source: Gene)
Source: Gene - November 2, 2023 Category: Genetics & Stem Cells Authors: Randy P Williams Corina Lesseur Haoxiang Cheng Qian Li Maya Deyssenroth Christopher D Molteno Ernesta M Meintjes Sandra W Jacobson Joseph L Jacobson Helen Wainwright Ke Hao Jia Chen R Colin Carter Source Type: research

Transcranial magnetic stimulation as a feasible, non-invasive, neuromodulatory intervention in fetal alcohol spectrum disorders. A very first proof of concept
CONCLUSION: FASD is a very complex disorder that is difficult to treat. In addition, comorbidities as atypical responses to pharmacotherapies are frequent. For this reason, non-invasive, innovative therapies for children with FASD have to be developed. For the first time, rTMS was shown to be safe, tolerable, and acceptable and thus well feasible in paediatric patients with FASD. Further clinical studies with larger samples are needed to identify effective stimulation protocols and to evaluate treatment response.PMID:37913649 | DOI:10.1016/j.ejpn.2023.10.004 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - November 1, 2023 Category: Neurology Authors: Anja Melder Esther Wittmann Lucia Bulubas Beate Dornheim Katharina Kerber Ulrike Vogelmann Mattia Campana Jasmin Hubert Vivien Schmidt Florian Heinen Frank Padberg Mirjam N Landgraf Source Type: research