Fetal Alcohol Syndrome Disorder Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol
Introduction Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%–94% of children with FASD meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is a paucity of evidence around medication efficacy for ADHD symptoms in children with FASD. This series of N-of-1 trials aims to provide pilot data on the feasibility of conducting N-of-1 trials in children with FASD and ADHD. Methods and analysis...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Crichton, A., Harris, K., McGree, J. M., Nikles, J., Anderson, P. J., Williams, K. Tags: Open access, Paediatrics Source Type: research

Carer-reported sleep disturbance and carer- and teacher-rated executive functioning in children with prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder
Child Neuropsychol. 2024 Apr 12:1-22. doi: 10.1080/09297049.2024.2337715. Online ahead of print.ABSTRACTChildren with prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorder (FASD) have high rates of sleep disturbance and marked difficulties with executive functioning (EF). Sleep disturbance has been associated with poorer EF across development in typically developing children. The contribution of insomnia symptoms and nightmares to EF difficulties in children with PAE and FASD is unclear. The current study examined whether caregiver-reported insomnia symptoms and nightmares predicted difficulties with EF in ch...
Source: Child Neuropsychology - April 12, 2024 Category: Child Development Authors: Ned Chandler-Mather Ali Crichton Doug Shelton Katrina Harris Caroline Donovan Sharon Dawe Source Type: research

Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure
Prenatal alcohol exposure (PAE) occurs in ~11% of North American pregnancies and is the most common known cause of neurodevelopmental disabilities such as fetal alcohol spectrum disorder (FASD; ~2–5% prevalence). PAE has been consistently associated with smaller gray matter volumes in children, adolescents, and adults. A small number of longitudinal studies show altered gray matter development trajectories in late childhood/early adolescence, but patterns in early childhood and potential sex differences have not been characterized in young children. Using longitudinal T1-weighted MRI, the present study characterized gray...
Source: Frontiers in Human Neuroscience - April 10, 2024 Category: Neuroscience Source Type: research

Fetal alcohol spectrum disorder diagnostic clinic capacity in Canadian Provinces and territories
This study investigated the diagnostic capacity for Fetal Alcohol Spectrum Disorder (FASD) in multidisciplinary clinics across several provincial and one territorial jurisdictions of Canada: Alberta, British Columbia, Manitoba, Ontario and Northwest Territories. The data were collected directly fr om clinics capable of providing diagnoses of FASD and examined annual capacity for the assessment and diagnosis of FASD per year from 2015 to 2019. In total, 58 FASD diagnostic clinics were identified and 33 clinics participated in this survey. The study identified inadequate FASD diagnostic capacit y in all participating jurisdi...
Source: PLoS One - April 3, 2024 Category: Biomedical Science Authors: Svetlana Popova Source Type: research

Perceptions of perinatal alcohol use and treatment needs in Cape Town, South Africa: a qualitative study
ConclusionsFindings from this study highlight the need for an alcohol intervention programme that is innovative and tailored to the needs of women who are pregnant or postpartum. It also highlights the importance of including community-based support and partner involvement in these interventions. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 13, 2024 Category: Psychiatry Source Type: research

Reduced Interhemispheric Coherence and Cognition in Children with Fetal Alcohol Spectrum Disorder (FASD) —A Quantitative EEG Study
Conclusion Our findings could imply hypoconnectivity between the hemispheres with impact on cognition. We suggest that EEG coherence analysis could be a sensitive parameter in the detection of electrophysiological abnormalities in FASD with possible clinical relevance. These results may indicate that QEEG could be used as biomarker for FASD. However, further research is needed to determine the role of QEEG analysis in the diagnosis of FASD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Neuropediatrics)
Source: Neuropediatrics - March 6, 2024 Category: Neurology Authors: Gerstner, Thorsten Henning, Oliver L øhaugen, Gro Skranes, Jon Tags: Original Article Source Type: research

Constitutional chromosomal anomalies in children, fetal alcohol syndrome, and maternal toxicant exposures: A longitudinal cohort study
Mutat Res Genet Toxicol Environ Mutagen. 2024 Feb-Mar;894:503737. doi: 10.1016/j.mrgentox.2024.503737. Epub 2024 Feb 9.ABSTRACTDNA alterations in gametes, which may occur either spontaneously or as a result of exposure to genotoxicants, can lead to constitutional chromosomal anomalies in the offspring. Alcohol is an established genotoxicant. The goal of this hypothesis-testing longitudinal cohort study was to evaluate the effect of significant/sustained maternal alcohol exposure on clinically diagnosed constitutional chromosomal anomalies among children diagnosed with fetal alcohol syndrome (FAS). De-identified eligibility...
Source: Cell Research - March 3, 2024 Category: Cytology Authors: David A Geier Mark R Geier Source Type: research

GSE134588 Maternal folic acid overconsumption in mice leads to sex-specific transcriptional alterations in cerebral cortex in offspring
Contributors : Marta Cos ín-Tomás ; Yan Luan ; Daniel Leclerc ; Olga Maleysheva ; Nidia Lauzon ; Renata H Bahous ; Karen Christensen ; Marie Caudill ; Rima RozenSeries Type : Expression profiling by arrayOrganism : Mus musculusRecent concerns have been raised regarding high folate intake during pregnancy and lactation, particularly following food forti ﬁcation and increased vitamin supplement use. Epidemiologic studies have shown that high folic acid (FA) intake can negatively impact motor and neurocognitive development in offspring.We used microarray to investigate the mechanisms by which a supplemented diet c...
Source: GEO: Gene Expression Omnibus - March 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Scoping review on the role of the family doctor in the prevention and care of patients with foetal alcohol spectrum disorder
CONCLUSION: The interventions of GPs in the management of patients with FASD are comprehensive: prevention, identification, diagnosis, follow-up, education, and the role of coordinator for patients, their families, and pregnant women and their partners. Prevention interventions would decrease the incidence of FASD, thereby reducing the incidence of mental retardation, developmental delays, and social, educational and legal issues. A further study with a cluster randomized trial with a group of primary care practitioners trained in screening for alcohol use during pregnancy would be useful to measure the impact of training ...
Source: Primary Care - February 22, 2024 Category: Primary Care Authors: S ébastien Leruste B érénice Doray Thierry Maillard Christophe Lebon Catherine Marimoutou Michel Spodenkiewicz Source Type: research

Scoping review on the role of the family doctor in the prevention and care of patients with foetal alcohol spectrum disorder
Foetal alcohol spectrum disorder (FASD) is the leading preventable cause of nongenetic mental disability. Given the patient care pathway, the General Practitioner (GP) is in the front line of prevention and id... (Source: BMC Family Practice)
Source: BMC Family Practice - February 22, 2024 Category: Primary Care Authors: S ébastien Leruste, Bérénice Doray, Thierry Maillard, Christophe Lebon, Catherine Marimoutou and Michel Spodenkiewicz Tags: Research Source Type: research

‘No one believed us: no one came to help’: caregivers' experiences of violence and abuse involving children with fetal alcohol spectrum disorder
AbstractChild and adolescent-to-parent violence and abuse (CAPVA) refers to abusive and violent behaviours by children towards their parents or primary caregivers. The abuse and harmful behaviours can include a full range of physical, emotional, verbal, financial, and material actions over prolonged periods of time, from childhood to young adulthood. Parents and caregivers of children with neuro-developmental conditions are vulnerable to CAPVA, and little research has been undertaken exploring the experiences of caregivers of children with fetal alcohol spectrum disorder (FASD). In Aotearoa New Zealand, 56 caregivers were ...
Source: Australian and New Zealand Journal of Family Therapy (ANZJFT) - February 18, 2024 Category: Psychiatry & Psychology Authors: Anita Gibbs Tags: ORIGINAL ARTICLE Source Type: research

Juvenile Competency Complications: Protocol, Unmet Needs, Developmental Immaturity, FASD, and Comorbidity
Am J Law Med. 2023 Jul;49(2-3):173-192. doi: 10.1017/amj.2023.26. Epub 2024 Feb 12.ABSTRACTThis Article focuses on unifying the protocol for state competency evaluations, but with special concerns about undiagnosed FASD and developmental immaturity in adolescents. States do not mandate any process whereby psychometric tests are first performed prior to psychiatric mental status evaluations, often causing disparities in evaluations which might easily be avoided in court proceedings. Adding to the complications in current competency evaluations are recent studies from Canada and Australia identifying exceptionally high rates...
Source: American Journal of Law and Medicine - February 12, 2024 Category: Medical Law Authors: David R Katner Source Type: research