Fetal Alcohol Syndrome Disorder Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Using meconium to establish prenatal alcohol exposure in the UK: ethical, legal and social considerations
An expanding policy framework aimed at monitoring alcohol consumption during pregnancy has emerged. The primary justification is prevention of harm from what is termed ‘prenatal alcohol exposure’ (PAE), by enabling more extensive diagnosis of the disability labelled fetal alcohol spectrum disorder (FASD). Here we focus on proposals to include biomarkers as a PAE ‘screening tool’, specifically those found in meconium (the first newborn excrement), which are discussed as an ‘objective’ measure of PAE. We ask the overarching question, ‘Can routine screening of meconium to establish PA...
Source: Journal of Medical Ethics - July 24, 2023 Category: Medical Ethics Authors: Arkell, R., Lee, E. Tags: Current controversy Source Type: research

Ethanol-induced AMPA alterations are mediated by mGLU5 receptors through miRNA upregulation in hippocampal slices
Eur J Pharmacol. 2023 Jul 9:175878. doi: 10.1016/j.ejphar.2023.175878. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) affects neuronal networks and brain development causing a range of physical, cognitive and behavioural disorders in newborns that persist into adulthood. The array of consequences associated with PAE can be grouped under the umbrella-term 'fetal alcohol spectrum disorders' (FASD). Unfortunately, there is no cure for FASD as the molecular mechanisms underlying this pathology are still unknown. We have recently demonstrated that chronic EtOH exposure, followed by withdrawal, induces a significa...
Source: European Journal of Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Elisabetta Gerace Lorenzo Curti Lucia Caffino Elisabetta Bigagli Francesca Mottarlini Fernando Castillo D íaz Alice Ilari Cristina Luceri Carlo Dani Fabio Fumagalli Alessio Masi Guido Mannaioni Source Type: research

Genes, Vol. 14, Pages 1392: ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder
ałecka Increasing alcohol consumption by women of childbearing age contributes to more frequent cases of fetal alcohol spectrum disorder. The cause of the syndrome is fetal alcohol exposure, particularly what is referred to as high prenatal alcohol exposure. Low metabolic activity of fetal enzymes shifts the burden of ethanol removal to maternal metabolism. One of the factors influencing the pathogenesis of FASD is the genetic background. It can determine the rate of elimination of ethanol, thus increasing or decreasing the time of fetal exposure to ethanol and also decreasing its concentration. Genetic polymorphisms ...
Source: Genes - July 2, 2023 Category: Genetics & Stem Cells Authors: Arnold Kukowka Bogus ław Brzuchalski Mateusz Kurzawski Damian Malinowski Monika Anna Bia łecka Tags: Article Source Type: research

Abortion, Impairment, and Well-Being
J Med Philos. 2023 Jun 28:jhad031. doi: 10.1093/jmp/jhad031. Online ahead of print.ABSTRACTHendricks' The Impairment Argument (TIA) claims that it is immoral to impair a fetus by causing it to have fetal alcohol syndrome (FAS). Since aborting a fetus impairs it to a greater degree than causing it to have FAS, then abortion is also immoral. In this article, I argue that TIA ought to be rejected. This is because TIA can only succeed if it explains why causing an organism to have FAS impairs it to a morally objectionable degree, entails that abortion impairs an organism to a morally objectionable and greater degree than causi...
Source: The Journal of Medicine and Philosophy - June 28, 2023 Category: Medical Ethics Authors: Alex R Gillham Source Type: research

Dog-Assisted Therapy vs Relaxation for Children and Adolescents with Fetal Alcohol Spectrum Disorder: A Randomized Controlled Study
J Autism Dev Disord. 2023 Jun 20. doi: 10.1007/s10803-023-06023-5. Online ahead of print.ABSTRACTThe rationale of this study was to evaluate the efficacy of Dog-assisted Therapy (DAT) in children and adolescents with Fetal Alcohol Spectrum Disorder (FASD). We conducted a randomized controlled trial in a cohort of 71 children and adolescents with FASD. Participants were randomly assigned either to DAT group (n = 38) or Relaxation Group (control group) (n = 33). Results revealed that participants who were assigned to the DAT group experienced significantly reduced externalizing symptoms (CBCL Externalizing Inattention: t (69...
Source: Journal of Autism and Developmental Disorders - June 20, 2023 Category: Psychiatry Authors: Raquel Vidal Laura Vidal Jorge Lugo Francesc Ristol Eva Dom ènec Teresa Casas Anna Veiga Cristina Vico Josep Antoni Ramos-Quiroga Nuria G ómez-Barros Source Type: research

Growth response of syndromic versus non-syndromic children born small for gestational age (SGA) to growth hormone therapy: a Belgian study
ConclusionsCompared to non-syndromic SGA patients, syndromic SGA patients were shorter when starting rhGH therapy, started rhGH therapy earlier, and received a higher dose of rhGH. At AH, syndromic SGA patients were shorter than non-syndromic ones, but their height gain under rhGH therapy was comparable. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research

Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools
CONCLUSIONS: Biomarkers and screening tools of PAE and its impact fall short of ideal predictive validity characteristics. Higher specificity than sensitivity was found for many of the biomarkers and screening tools used to identify PAE and its impact, suggesting that current methods continue to under-identify the full range of individuals impacted by PAE. Exceptions to this were found in recent investigations using microRNAs related to growth and vascular development, proteomic changes associated with PAE, and combinations of markers estimating levels of various cytokines. Replications of these findings are needed across ...
Source: Alcohol Research - June 1, 2023 Category: Addiction Authors: Julie A Kable Kenneth Lyons Jones Source Type: research