Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway
In this study, we evaluated the anti-angiogenic and anti-proliferative effects of a hydro-alcoholic extract of fenugreek seed (HAEF) on human umbilical vein endothelial cells (HUVECs). Human umbilical vein endothelial cells were treated with various concentrations of HAEF and the half-maximal inhibitory concentration (IC50) value was estimated by using the MTT assay. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and matrix metalloproteinase enzyme (MMP-2 and MMP-9) gene expression profiles were evaluated by using quantitative RT-PCR (qRT-PCR). Moreover, MMP activities and PI3K, Akt and cy...
Source: Alternatives to Laboratory Animals : ATLA - June 22, 2023 Category: Research Authors: Samaneh Safarpour Farshad Mirzavi Farzad Rahmani Fatemeh Forouzanfar Hamid Reza Sadeghnia Baratali Mashkani Daryoush Hamidi Alamdari Mohammad Soukhtanloo Source Type: research
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway
In this study, we evaluated the anti-angiogenic and anti-proliferative effects of a hydro-alcoholic extract of fenugreek seed (HAEF) on human umbilical vein endothelial cells (HUVECs). Human umbilical vein endothelial cells were treated with various concentrations of HAEF and the half-maximal inhibitory concentration (IC50) value was estimated by using the MTT assay. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and matrix metalloproteinase enzyme (MMP-2 and MMP-9) gene expression profiles were evaluated by using quantitative RT-PCR (qRT-PCR). Moreover, MMP activities and PI3K, Akt and cy...
Source: Alternatives to Laboratory Animals : ATLA - June 22, 2023 Category: Research Authors: Samaneh Safarpour Farshad Mirzavi Farzad Rahmani Fatemeh Forouzanfar Hamid Reza Sadeghnia Baratali Mashkani Daryoush Hamidi Alamdari Mohammad Soukhtanloo Source Type: research
Multivariate analysis of seed chemical diversity among wild fenugreek (Trigonella monantha C. A. Mey.) ecotypes
Wild fenugreek (Trigonella monantha), a multi-purpose annual plant, has traditionally been used as a food, forage, and medicinal plant. However, the knowledge of the diversity of its chemical characteristics is l... (Source: BMC Plant Biology)
Source: BMC Plant Biology - June 16, 2023 Category: Biology Authors: Neda Esamaeilinejad Hasaroeih, Farangis Ghanavati, Foad Moradi, Jahangir Abbasi Kohpalkani and Majid Rahimizadeh Tags: Research Source Type: research
Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi-target pharmacology of fenugreek against diabetes
J Cell Mol Med. 2023 May 31. doi: 10.1111/jcmm.17787. Online ahead of print.ABSTRACTFenugreek is an ancient herb that has been used for centuries to treat diabetes. However, how the fenugreek-derived chemical compounds work in treating diabetes remains unclarified. Herein, we integrate molecular docking and network pharmacology to elucidate the active constituents and potential mechanisms of fenugreek against diabetes. First, 19 active compounds from fenugreek and 71 key diabetes-related targets were identified through network pharmacology analysis. Then, molecular docking and simulations results suggest diosgenin, luteoli...
Source: Molecular Medicine - May 31, 2023 Category: Molecular Biology Authors: Wenfeng Luo Jie Deng Jiecheng He Liang Yin Rong You Lingkun Zhang Jian Shen Zeping Han Fangmei Xie Jinhua He Yanqing Guan Source Type: research
Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi-target pharmacology of fenugreek against diabetes
J Cell Mol Med. 2023 May 31. doi: 10.1111/jcmm.17787. Online ahead of print.ABSTRACTFenugreek is an ancient herb that has been used for centuries to treat diabetes. However, how the fenugreek-derived chemical compounds work in treating diabetes remains unclarified. Herein, we integrate molecular docking and network pharmacology to elucidate the active constituents and potential mechanisms of fenugreek against diabetes. First, 19 active compounds from fenugreek and 71 key diabetes-related targets were identified through network pharmacology analysis. Then, molecular docking and simulations results suggest diosgenin, luteoli...
Source: J Cell Mol Med - May 31, 2023 Category: Molecular Biology Authors: Wenfeng Luo Jie Deng Jiecheng He Liang Yin Rong You Lingkun Zhang Jian Shen Zeping Han Fangmei Xie Jinhua He Yanqing Guan Source Type: research
The Anabolic Effect of Fenugreek: A Systematic Review with
Meta-analysis
Int J Sports Med DOI: 10.1055/a-2048-5925The use of plant steroids to improve physical health and performance is becoming
increasingly popular. One of these plant steroids is diosgenin, which is mainly
available in fenugreek. As a result, some studies have been conducted to improve
physical health. Fenugreek extracts are also becoming increasingly popular in
the context of athletic performance. Based on these assumptions, a systematic
review with meta-analysis was conducted to evaluate the promoting effects of
fenugreek on strength performance, body composition, a...
Source: International Journal of Sports Medicine - May 30, 2023 Category: Sports Medicine Authors: Isenmann, Eduard Alisauskas, Pijus Flenker, Ulrich Schalla, Jan Diel, Patrick Tags: Review Source Type: research
Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease
DISCUSSION: Fenugreek significantly improves the pathological symptoms of neurodegenerative disease, especially AD and can be used as a therapeutic agent to control disease conditions as evidenced by the review of the literature.PMID:37231762 | DOI:10.2174/1567205020666230525154300 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - May 26, 2023 Category: Neurology Authors: Himanshi Varshney Yasir Hasan Siddique Source Type: research
Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease
DISCUSSION: Fenugreek significantly improves the pathological symptoms of neurodegenerative disease, especially AD and can be used as a therapeutic agent to control disease conditions as evidenced by the review of the literature.PMID:37231762 | DOI:10.2174/1567205020666230525154300 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - May 26, 2023 Category: Neurology Authors: Himanshi Varshney Yasir Hasan Siddique Source Type: research
Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease
DISCUSSION: Fenugreek significantly improves the pathological symptoms of neurodegenerative disease, especially AD and can be used as a therapeutic agent to control disease conditions as evidenced by the review of the literature.PMID:37231762 | DOI:10.2174/1567205020666230525154300 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - May 26, 2023 Category: Neurology Authors: Himanshi Varshney Yasir Hasan Siddique Source Type: research
Synergism and toxicity of iron nanoparticles derived from Trigonella foenum-graecum against pyrethriod treatment in S. litura and H. armigera (Lepidoptera: Noctuidae)
Environ Res. 2023 May 6:116079. doi: 10.1016/j.envres.2023.116079. Online ahead of print.ABSTRACTThe tobacco cutworm, Spodoptera litura and cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) are important pests of various agricultural crops that cause sevier economic loses throughout the world. Indiscriminate and frequent use of insecticide may lead to development of resistance in these pests. Nanotechnology has given an alternative to manage and overcome insecticide resistance for pest management strategies. In the present study the iron nanoparticles derived from Trigonella foenum-graecum leaf extract (FeNPs)...
Source: Environmental Research - May 8, 2023 Category: Environmental Health Authors: Ranganathan Muthusamy Govindaraju Ramkumar Suresh Kumarasamy Nguyen Thuy Lan Chi Sami Al Obaid Saleh Alfarraj Indira Karuppusamy Source Type: research
Synergism and toxicity of iron nanoparticles derived from Trigonella foenum-graecum against pyrethriod treatment in S. litura and H. armigera (Lepidoptera: Noctuidae)
Environ Res. 2023 May 6:116079. doi: 10.1016/j.envres.2023.116079. Online ahead of print.ABSTRACTThe tobacco cutworm, Spodoptera litura and cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) are important pests of various agricultural crops that cause sevier economic loses throughout the world. Indiscriminate and frequent use of insecticide may lead to development of resistance in these pests. Nanotechnology has given an alternative to manage and overcome insecticide resistance for pest management strategies. In the present study the iron nanoparticles derived from Trigonella foenum-graecum leaf extract (FeNPs)...
Source: Environmental Research - May 8, 2023 Category: Environmental Health Authors: Ranganathan Muthusamy Govindaraju Ramkumar Suresh Kumarasamy Nguyen Thuy Lan Chi Sami Al Obaid Saleh Alfarraj Indira Karuppusamy Source Type: research
A comprehensive review on Trigonella foenum-graecum L. with special reference to Unani medicine
This article seeks to underscore the potential of Hulba in addressing a variety of health conditions as identified by esteemed classical Unani scholars, as well as to investigate its phytochemistry and pharmacological properties in contemporary medicine. The authors have utilized electronic databases, such as PubMed, Science Direct, DOAJ, Google Scholar, and Ayush Research Portal to filter published material. According to the gathered literature, Unani physicians have consistently recommended Ḥulba seeds for a variety of ailments, such as indigestion, flatulence, colitis, arthritis, backache, paralysis, headaches, common...
Source: Combinatorial Chemistry and High Throughput Screening - May 5, 2023 Category: Chemistry Authors: Faiza Khatoon Mohd Azahar Qamar Uddin Nazim Husain Md Sanaul Moin Shayni Khan Source Type: research
A comprehensive review on Trigonella foenum-graecum L. with special reference to Unani medicine
This article seeks to underscore the potential of Hulba in addressing a variety of health conditions as identified by esteemed classical Unani scholars, as well as to investigate its phytochemistry and pharmacological properties in contemporary medicine. The authors have utilized electronic databases, such as PubMed, Science Direct, DOAJ, Google Scholar, and Ayush Research Portal to filter published material. According to the gathered literature, Unani physicians have consistently recommended Ḥulba seeds for a variety of ailments, such as indigestion, flatulence, colitis, arthritis, backache, paralysis, headaches, common...
Source: Combinatorial Chemistry and High Throughput Screening - May 5, 2023 Category: Chemistry Authors: Faiza Khatoon Mohd Azahar Qamar Uddin Nazim Husain Md Sanaul Moin Shayni Khan Source Type: research
A comprehensive review on Trigonella foenum-graecum L. with special reference to Unani medicine
This article seeks to underscore the potential of Hulba in addressing a variety of health conditions as identified by esteemed classical Unani scholars, as well as to investigate its phytochemistry and pharmacological properties in contemporary medicine. The authors have utilized electronic databases, such as PubMed, Science Direct, DOAJ, Google Scholar, and Ayush Research Portal to filter published material. According to the gathered literature, Unani physicians have consistently recommended Ḥulba seeds for a variety of ailments, such as indigestion, flatulence, colitis, arthritis, backache, paralysis, headaches, common...
Source: Combinatorial Chemistry and High Throughput Screening - May 5, 2023 Category: Chemistry Authors: Faiza Khatoon Mohd Azahar Qamar Uddin Nazim Husain Md Sanaul Moin Shayni Khan Source Type: research
Perception of herbs use in treating diabetes among patients attending specialized polyclinics of National Guard Health Affairs, Jeddah
CONCLUSION: This study concluded that herbs are commonly used among diabetic patients and the majority of patients perceive herbs as a cofactor in controlling diabetes.PMID:37091011 | PMC:PMC10114559 | DOI:10.4103/jfmpc.jfmpc_1155_22 (Source: Primary Care)
Source: Primary Care - April 24, 2023 Category: Primary Care Authors: Mahmoud A Alzahrani Khulood A Alsiary Muhammad A Khan Adeeb Bushnaq Bassam Alzahrani Marwan Salama Nawaf S Alamri Source Type: research
