Molecules, Vol. 28, Pages 7798: HPLC-DAD-MS Characterization, Antioxidant Activity, & alpha;-amylase Inhibition, Molecular Docking, and ADMET of Flavonoids from Fenugreek Seeds
Molecules, Vol. 28, Pages 7798: HPLC-DAD-MS Characterization, Antioxidant Activity, α-amylase Inhibition, Molecular Docking, and ADMET of Flavonoids from Fenugreek Seeds
Molecules doi: 10.3390/molecules28237798
Authors:
Mohammed Lamine Khenifi
Talia Serseg
Piotr Migas
Mirosława Krauze-Baranowska
Sadin Özdemir
Chawki Bensouici
Mohammed I. Alghonaim
Khattab Al-Khafaji
Sulaiman A. Alsalamah
Messaoud Boudjeniba
Mohamed Yousfi
Fehmi Boufahja
Hamdi Bendif
Mohamed Mahdid
Fenugreek (Trigonella foenum-graecum) has a great beneficial health effect; it has been used in traditional medicin...
Source: Molecules - November 27, 2023 Category: Chemistry Authors: Mohammed Lamine Khenifi Talia Serseg Piotr Migas Miros ława Krauze-Baranowska Sadin Özdemir Chawki Bensouici Mohammed I. Alghonaim Khattab Al-Khafaji Sulaiman A. Alsalamah Messaoud Boudjeniba Mohamed Yousfi Fehmi Boufahja Hamdi Bendif Mohamed Mahdid Tags: Article Source Type: research
The role of fenugreek seed extract in alleviating pancreatic toxic effects and altering glucose homeostasis induced by acetamiprid via modulation of oxidative stress, apoptosis, and autophagy
Tissue Cell. 2023 Nov 5;86:102265. doi: 10.1016/j.tice.2023.102265. Online ahead of print.ABSTRACTAcetamiprid (ACMP) is a second-generation neonicotinoid that has been extensively used in the last few years. The present study examined the toxic effects of ACMP on the pancreas and glucose homeostasis through the evaluation of histological and biochemical changes and the possible ameliorative role of fenugreek seed extract (FG). Fifty adult albino rats were divided into 5 groups: negative control, positive control, FG-treated, ACMP-treated, and ACMP + FG-treated groups by oral gavage for 12 weeks. The ACMP-treated group high...
Source: Tissue and Cell - November 10, 2023 Category: Cytology Authors: Samah A El-Nagdy Yara M Elfakharany Manal Mohammad Morsy Marwa M Ahmad Samaa Salah Abd El-Fatah Eman El-Sayed Khayal Source Type: research
The role of fenugreek seed extract in alleviating pancreatic toxic effects and altering glucose homeostasis induced by acetamiprid via modulation of oxidative stress, apoptosis, and autophagy
Tissue Cell. 2023 Nov 5;86:102265. doi: 10.1016/j.tice.2023.102265. Online ahead of print.ABSTRACTAcetamiprid (ACMP) is a second-generation neonicotinoid that has been extensively used in the last few years. The present study examined the toxic effects of ACMP on the pancreas and glucose homeostasis through the evaluation of histological and biochemical changes and the possible ameliorative role of fenugreek seed extract (FG). Fifty adult albino rats were divided into 5 groups: negative control, positive control, FG-treated, ACMP-treated, and ACMP + FG-treated groups by oral gavage for 12 weeks. The ACMP-treated group high...
Source: Tissue and Cell - November 10, 2023 Category: Cytology Authors: Samah A El-Nagdy Yara M Elfakharany Manal Mohammad Morsy Marwa M Ahmad Samaa Salah Abd El-Fatah Eman El-Sayed Khayal Source Type: research
Fabrication and evaluation of anticancer potential of diosgenin incorporated chitosan-silver nanoparticles; in vitro, in silico and in vivo studies
Int J Biol Macromol. 2023 Nov 7:127975. doi: 10.1016/j.ijbiomac.2023.127975. Online ahead of print.ABSTRACTThe discovery of effective therapeutic approaches with minimum side effects and their tendency to completely eradicate the disease is the main challenge in the history of cancer treatment. Fenugreek (FGK) seeds are a rich source of phytochemicals, especially Diosgenin (DGN), which shows outstanding anticancer activities. In the present study, chitosan-silver nanoparticles (ChAgNPs) containing Diosgenin (DGN-ChAgNPs) were synthesized and evaluated for their anticancer activity against breast cancer cell line (MCF-7). F...
Source: International Journal of Biological Macromolecules - November 9, 2023 Category: Biochemistry Authors: Sumera Zaib Hamid Saeed Shah Imtiaz Khan Zobia Jawad Muhammad Sarfraz Huma Riaz Hafiz Muhammad Mazhar Asjad Memoona Ishtiaq Hanan A Ogaly Gehan Othman Dalia Abd El Moneim Ahmed Source Type: research
Fenugreek Seed Ethanolic Extract Improves Alveolar Bone Parameters by Attenuating Inflammation in Ovariectomized Rats
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - October 30, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research
Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7
CONCLUSION: Our findings indicate that TRL can alleviate tubular epithelial-mesenchymal transition and renal fibrosis in db/db mice by upregulating Smad7 in PTCs, suggesting that TRL is a promising medicine against DKD.PMID:37864898 | DOI:10.1016/j.biopha.2023.115747 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 21, 2023 Category: Drugs & Pharmacology Authors: Minmin Gong Yujin Guo Hui Dong Wenbin Wu Fan Wu Fuer Lu Source Type: research
