Evaluation of safety margins for cone beam CT-based adaptive prostate radiotherapy
External beam radiotherapy treatment delivery entails uncertainties [1,2] that can affect the coverage of the target and therefore the treatment outcome [3,4]. In order to account for them, a margin is added to the clinical target volumes (CTV) to create planning target volumes (PTV). This margin depends on the uncertainties that we are dealing with, and can be computed using safety margin recipes, for instance the so-called Van Herk formula [5]. This recipe is based on the separation of systematic uncertainties, that affect the treatment as a whole, and the random uncertainties, that affect each fraction independently. (S...
Source: Physica Medica: European Journal of Medical Physics - April 24, 2024 Category: General Medicine Authors: Florian Dupont, David Dechambre, Edmond Sterpin Tags: Original paper Source Type: research
Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up
CONCLUSION: Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up.PMID:38652872 | DOI:10.1200/JCO.23.01391 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Christian Ekanger Svein Inge Helle Lars Reis æter Liv Bolstad Hysing Rune Kv åle Alfred Honor é Karsten Gravdal Sara Pilskog Olav Dahl Source Type: research
Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up
CONCLUSION: Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up.PMID:38652872 | DOI:10.1200/JCO.23.01391 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Christian Ekanger Svein Inge Helle Lars Reis æter Liv Bolstad Hysing Rune Kv åle Alfred Honor é Karsten Gravdal Sara Pilskog Olav Dahl Source Type: research
Immunoradiotherapy for NSCLC: mechanisms, clinical outcomes, and future directions
AbstractNon-small-cell lung cancer (NSCLC) has an extremely low 5-year survival rate, with the only effective treatment being immunoradiotherapy (iRT). Here, we review the progress of clinical research on iRT for non-small-cell lung cancer (NSCLC) over 2018 –2023, as well as the future directions. We first discuss the synergistic mechanisms of iRT, reflected in three aspects: immune regulation of RT, RT-activated immune-related pathways, and RT-related immune sensitization. iRT may include either external-beam or stereotactic-body RT combined with ei ther immune checkpoint inhibitors (e.g., immunoglobulins against immune...
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Exploratory study of using Magnetic resonance Prognostic Imaging markers for Radiotherapy In Cervix cancer (EMPIRIC): a prospective cohort study protocol
Introduction
Radical chemoradiotherapy represents the gold standard for locally advanced cervical cancer. However, despite significant progress in improving local tumour control, distant relapse continues to impact overall survival. The development of predictive and prognostic biomarkers is consequently important to risk-stratify patients and identify populations at higher risk of poorer treatment response and survival outcomes. Exploratory study of using Magnetic resonance Prognostic Imaging markers for Radiotherapy In Cervix cancer (EMPIRIC) is a prospective exploratory cohort study, which aims to investigate the role of...
Source: BMJ Open - April 18, 2024 Category: General Medicine Authors: Abdul-Latif, M., Chowdhury, A., Tharmalingam, H., Taylor, N. J., Lakhani, A., Padhani, A., Hoskin, P., Tsang, Y. Tags: Open access, Radiology and imaging Source Type: research
Large Skull Metastasis in Follicular Thyroid Carcinoma: A Comprehensive Case Presentation and Systematic Review
Conclusion Managing secondary skull metastases from FTC requires a comprehensive approach, including surgical intervention, radiotherapy, and potential systemic therapies. The rarity of these metastases underscores the need for further research to establish standardized treatment guidelines, explore molecular profiling, and investigate immunotherapy and combination therapies, offering hope for improved outcomes in this challenging clinical scenario. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - April 15, 2024 Category: Neurosurgery Authors: Scalia, Gianluca Porzio, Massimiliano Costanzo, Roberta Giurato, Eliana Gibilisco, Fabio Iacopino, Domenico Gerardo Maugeri, Rosario Nicoletti, Giovanni Federico Umana, Giuseppe Emmanuele Alessandrello, Raffaele Tags: Review Article Source Type: research
Management of Intraocular Retinoblastoma: ICMR Consensus Guidelines
AbstractRetinoblastoma (RB) is the most common childhood intraocular malignancy. Delayed presentation due to a lack of awareness and advanced intraocular tumors are a common scenario in low-middle income countries (LMICs). Remarkable treatment advances have been made in the past few decades allowing globe salvage in advanced intraocular RB (IORB) including systemic chemotherapy with focal consolidation and targeted treatments like intraarterial chemotherapy and intravitreal chemotherapy. However, a lack of availability and affordability limits the use of such advances in LMICs. External beam radiotherapy, despite risk of s...
Source: Indian Journal of Pediatrics - April 13, 2024 Category: Pediatrics Source Type: research
Patient Reported Sexual Adaptation Following Prostate Cancer Treatment: An Analysis of Related Variables and Sexual Outcomes Associated with Sexual Adaptation Styles
Arch Sex Behav. 2024 Apr 12. doi: 10.1007/s10508-024-02855-z. Online ahead of print.ABSTRACTSexual concerns after prostate cancer (PCa) treatment are high. Flexible coping is a crucial element to maintaining sexual activity after PCa and improves adaptation outcomes. We aimed to identify potential sexual adaptation styles reported by men following PCa treatment, and to assess relationships among associated variables and outcomes. Individuals (n = 223) with PCa treatment history (e.g., radical prostatectomy [n = 165, 74.0%], external beam radiation [n = 83, 37.2%], hormone/androgen deprivation therapy [n = 83, 37.2%]), comp...
Source: Archives of Sexual Behavior - April 12, 2024 Category: Psychiatry & Psychology Authors: Fatima I Shah Fiona MacLeod Lauren M Walker Source Type: research
Patient Reported Sexual Adaptation Following Prostate Cancer Treatment: An Analysis of Related Variables and Sexual Outcomes Associated with Sexual Adaptation Styles
Arch Sex Behav. 2024 Apr 12. doi: 10.1007/s10508-024-02855-z. Online ahead of print.ABSTRACTSexual concerns after prostate cancer (PCa) treatment are high. Flexible coping is a crucial element to maintaining sexual activity after PCa and improves adaptation outcomes. We aimed to identify potential sexual adaptation styles reported by men following PCa treatment, and to assess relationships among associated variables and outcomes. Individuals (n = 223) with PCa treatment history (e.g., radical prostatectomy [n = 165, 74.0%], external beam radiation [n = 83, 37.2%], hormone/androgen deprivation therapy [n = 83, 37.2%]), comp...
Source: Archives of Sexual Behavior - April 12, 2024 Category: Psychiatry & Psychology Authors: Fatima I Shah Fiona MacLeod Lauren M Walker Source Type: research
Patient Reported Sexual Adaptation Following Prostate Cancer Treatment: An Analysis of Related Variables and Sexual Outcomes Associated with Sexual Adaptation Styles
Arch Sex Behav. 2024 Apr 12. doi: 10.1007/s10508-024-02855-z. Online ahead of print.ABSTRACTSexual concerns after prostate cancer (PCa) treatment are high. Flexible coping is a crucial element to maintaining sexual activity after PCa and improves adaptation outcomes. We aimed to identify potential sexual adaptation styles reported by men following PCa treatment, and to assess relationships among associated variables and outcomes. Individuals (n = 223) with PCa treatment history (e.g., radical prostatectomy [n = 165, 74.0%], external beam radiation [n = 83, 37.2%], hormone/androgen deprivation therapy [n = 83, 37.2%]), comp...
Source: Archives of Sexual Behavior - April 12, 2024 Category: Psychiatry & Psychology Authors: Fatima I Shah Fiona MacLeod Lauren M Walker Source Type: research
Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments
CONCLUSIONS: Plastic scintillator discs have characteristics that are well-suited for in vivo optical dosimetry for x-ray radiotherapy treatments. Unlike typical point dosimeters, there is no inherent readout time delay, and an optical recording of the measurement is saved after treatment for future reference. While several factors influence the integral output for the same dose, they have been quantified here and may be corrected in post-processing.PMID:38598093 | DOI:10.1002/mp.17071 (Source: Health Physics)
Source: Health Physics - April 10, 2024 Category: Physics Authors: Savannah M Decker Petr Bruza Rongxiao Zhang Benjamin B Williams Lesley A Jarvis Brian W Pogue David J Gladstone Source Type: research
Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report
ConclusionsAchieving long-term local control in pulmonary IMT can be challenging. Multimodality treatment is sometimes needed but the overall outlook remains good. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 10, 2024 Category: General Medicine Source Type: research
Dosimetric comparison of intra-cavitary brachytherapy technique with free-hand (intra-cavitary + interstitial) technique in cervical cancer
CONCLUSIONS: Free-hand brachytherapy (IC + IS) achieves a statistically significant better dose distribution to high-risk clinical target volume (HR-CTV) comparing with ICBT technique with similar dose to organs at risk.PMID:38584889 | PMC:PMC10993890 | DOI:10.5114/jcb.2024.135629 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 8, 2024 Category: Cancer & Oncology Authors: Sumukh Jamadagni Arul Ponni Tr Revathy P Source Type: research
Safety of high-dose-rate brachytherapy in patients with prostate cancer and inflammatory bowel disease: A case series
CONCLUSIONS: HDR brachytherapy appears to be a safe and tolerable treatment modality for patients with prostate cancer and IBD, with minimal acute and late GI and GU toxicity. These findings warrant multi-institutional validation due to small sample size.PMID:38584887 | PMC:PMC10993899 | DOI:10.5114/jcb.2024.135645 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - April 8, 2024 Category: Cancer & Oncology Authors: Horatio Thomas Jie Jane Chen Haitham Shaheen Ali Sabbagh Hasan Abdul-Baki Oi Wai Chau Nauman Malik Alan Ayoub Comron Hassanzadeh I-Chow Hsu Osama Mohamad Source Type: research
