Spatially Fractionated Radiation Therapy in Sarcomas: A Large Single-Institution Experience
CONCLUSIONS: The current series is the largest to date documenting outcomes for SFRT in sarcomas. Our results suggest combined SFRT with EBRT is associated with a favorable toxicity profile and high rates of symptomatic and radiographic responses for metastatic or unresectable sarcomas.PMID:38495033 | PMC:PMC10943518 | DOI:10.1016/j.adro.2023.101401 (Source: Adv Data)
Source: Adv Data - March 18, 2024 Category: Epidemiology Authors: Safia K Ahmed Ivy A Petersen Michael P Grams Randi R Finley Michael G Haddock Dawn Owen Source Type: research

A Randomized Trial Comparing Quality of Life After LDR or HDR Prostate Brachytherapy Boost with Pelvic External Beam Radiation Therapy
CONCLUSIONS: Patient experience for combined EBRT and prostate BT is improved with HDR BT. Urinary QoL improves over time to be equivalent between the 2 modalities after 18 months, but LDR patients report lasting bowel symptoms.PMID:38493901 | DOI:10.1016/j.ijrobp.2024.02.064 (Source: Health Physics)
Source: Health Physics - March 17, 2024 Category: Physics Authors: Juanita Crook Nikitha Moideen Greg Arbour Felipe Castro C ánovas Cynthia Araujo Deidre Batchelar Ross Halperin Michelle Hilts David Kim David Petrik Jim Rose J C Cheng Francois Bachand Source Type: research

Treatment intensification strategies for men undergoing definitive radiotherapy for high-risk prostate cancer
ConclusionTreatment intensification using a combination of EBRT, advanced hormonal therapies, and brachytherapy may improve patient outcomes and survival in men with high-risk prostate cancer. Shared decision-making between patients and multidisciplinary teams of radiation oncologists, urologists, and medical oncologists is essential for personalizing care in this setting and deciding which strategies make sense for individual patients. (Source: World Journal of Urology)
Source: World Journal of Urology - March 16, 2024 Category: Urology & Nephrology Source Type: research

Radiotherapy in localized prostate cancer: a multicenter analysis evaluating tumor control and late toxicity after brachytherapy and external beam radiotherapy in 1293 patients
CONCLUSION: All types of therapy were effective and well received. HDR-BT caused the least late toxicities, especially GI.PMID:38488901 | DOI:10.1007/s00066-024-02222-w (Source: Cancer Control)
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Matthias Moll Elisabeth Nechvile Christian Kirisits Oxana Komina Thomas Pajer Bettina Kohl Marcin Miszczyk Joachim Widder Tomas-Hendrik Knocke-Abulesz Gregor Goldner Source Type: research

Radiotherapy in localized prostate cancer: a  multicenter analysis evaluating tumor control and late toxicity after brachytherapy and external beam radiotherapy in 1293 patients
ConclusionAll types of therapy were effective and well received. HDR-BT caused the least late toxicities, especially GI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 15, 2024 Category: Cancer & Oncology Source Type: research

A Randomized Trial Comparing Quality of Life After LDR or HDR Prostate Brachytherapy Boost with Pelvic External Beam Radiation Therapy
To compare health-related Quality of Life (QoL) in urinary, bowel and sexual domains after combined external beam radiotherapy (EBRT) and either low dose rate (LDR) or high dose rate (HDR) prostate brachytherapy (BT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Juanita Crook, Nikitha Moideen, Greg Arbour, Felipe Castro C ánovas, Cynthia Araujo, Deidre Batchelar, Ross Halperin, Michelle Hilts, David Kim, David Petrik, Jim Rose, JC Cheng, Francois Bachand Tags: Clinical Investigation Source Type: research

Safety and Toxicity of Iopofosine I-131 with External Beam Radiation Therapy (EBRT) in Recurrent or Metastatic Head and Neck Cancer (HNC): Results of a Phase 1 Study
Retreatment of recurrent HNC is often limited by tumor adherence to critical structures or normal tissue tolerance to radiation therapy. Iopofosine I-131 (CLR 131) is a novel targeted small molecular phospholipid ether (PLE) drug conjugate that delivers iodine-131 selectively to malignant tumor cells optimized through specialized regions called lipid rafts. Radiation exposure is selective to cancer cells due to the interaction of the PLE with the highly enriched lipid rafts of the plasma membrane, which are non-reliant on cell surface markers. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J.Y. Bruce, A. Burr, R.J. Kimple, M. Yu, D. Trask, S. Piaskowski, K. Oliver, J. Longcor, S.Y. Cho, B. Bednarz, P.M. Harari Tags: 149 Source Type: research

External radiation therapy of primary central nervous system tumors - current trends and practice
Magy Onkol. 2024 Mar 14;68(1):37-50. Epub 2023 Oct 22.ABSTRACTThe family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.PMID:38484374 (Source: Magyar Onkologia)
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Árpád Kovács Source Type: research

External radiation therapy of primary central nervous system tumors - current trends and practice
Magy Onkol. 2024 Mar 14;68(1):37-50. Epub 2023 Oct 22.ABSTRACTThe family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.PMID:38484374 (Source: Magyar Onkologia)
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Árpád Kovács Source Type: research

External radiation therapy of primary central nervous system tumors - current trends and practice
Magy Onkol. 2024 Mar 14;68(1):37-50. Epub 2023 Oct 22.ABSTRACTThe family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.PMID:38484374 (Source: Magyar Onkologia)
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Árpád Kovács Source Type: research

Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response
Ionizing radiation has garnered considerable attention as a combination partner for immunotherapy due to its potential immunostimulatory effects. In contrast to the more commonly used external beam radiation, we explored the feasibility of combining chimeric antigen receptor (CAR) T cell therapy with targeted radionuclide therapy (TRT), which is achieved by delivering β-emitting 177Lu-DOTATATE to tumor via tumor-infiltrating CAR T cells that express somatostatin receptor 2 (SSTR2). We hypothesized that the delivery of radiation to tumors could synergize with CAR T therapy, resulting in enhanced antitumor immunity and tumo...
Source: Frontiers in Immunology - March 14, 2024 Category: Allergy & Immunology Source Type: research

Apparent diffusion coefficient values predict response to brachytherapy in bulky cervical cancer
Diffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radia... (Source: Radiation Oncology)
Source: Radiation Oncology - March 13, 2024 Category: Cancer & Oncology Authors: Elizabeth E. Dong, Junqian Xu, Joo-Won Kim, Jason Bryan, Jewel Appleton, Daniel A. Hamstra, Michelle S. Ludwig and Alexander N. Hanania Tags: Research Source Type: research

Concurrent nivolumab and external beam radiation therapy for hepatocellular carcinoma with macrovascular invasion: A phase II study
CONCLUSION: Concurrent nivolumab therapy and EBRT showed encouraging PFS with acceptable safety in patients with advanced HCC and macrovascular invasion.IMPACT AND IMPLICATIONS: Immune checkpoint inhibitors, the standard care for advanced hepatocellular carcinoma (HCC), show relatively poor therapeutic effects in patients with advanced HCC and macrovascular invasion. In this investigator-initiated phase II study, we, for the first time, show that concurrent external beam radiation therapy with nivolumab, an immune checkpoint inhibitor, led to encouraging progression-free survival in patients with HCC and macrovascular inva...
Source: Cancer Control - March 11, 2024 Category: Cancer & Oncology Authors: Bo Hyun Kim Hee Chul Park Tae Hyun Kim Young-Hwan Koh Jung Yong Hong Yuri Cho Dong Hyun Sinn Boram Park Joong-Won Park Source Type: research

BRACHYTHERAPY (Interventional Radiotherapy): The radiation oncologist opinion
Urologia. 2024 Mar 11:3915603241231732. doi: 10.1177/03915603241231732. Online ahead of print.ABSTRACTThe role of the radiation oncologist in the management of patients affected by prostate cancer is increasingly considered thanks to important technological innovations that have marked the radiotherapeutic approach in its three main fields: external beam radiotherapy (EB-RT), brachytherapy (interventional radiotherapy, I-RT), and metabolic radiotherapy (M-RT) through the use of new radiopharmaceuticals. Regarding the modern brachytherapy, the introduction of intensity-modulated techniques (IM-IRT), thanks to the implementa...
Source: Cancer Control - March 11, 2024 Category: Cancer & Oncology Authors: Luca Tagliaferri Vincenzo Valentini Source Type: research

Dosimetric impact of bone marrow sparing for robustly optimized IMPT for locally advanced cervical cancer
Standard treatment of locally advanced cervical cancer (LACC) combines external beam radiotherapy, cisplatin-based concurrent chemotherapy, and image-guided brachytherapy [1]. Although this treatment combination provides a good clinical outcome in terms of local and pelvic tumor control [2,3], it is associated with a high incidence of morbidities, including gastrointestinal (GI) and genitourinary (GU) toxicities as well as hematologic toxicity (HT) [4,5]. HT, and more specifically radiation-induced lymphopenia, has been associated with a poorer prognosis on overall survival [6,7]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 10, 2024 Category: Radiology Authors: S.C. Kuipers, J. Godart, A. Corbeau, S. Breedveld, J.W.M. Mens, S.M. de Boer, R.A. Nout, M.S. Hoogeman Tags: Original Article Source Type: research