Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report
CONCLUSIONS: The dose ratio of the sigmoid colon to HR-CTV D90 was decreased by introducing a hydrogel spacer into the meso-sigmoid. In cases where the sigmoid colon is in proximity to the cervical tumor, this novel technique can be considered to achieve better clinical outcomes.PMID:38230404 | PMC:PMC10789158 | DOI:10.5114/jcb.2023.134174 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Madoka Sakuramachi Naoya Murakami Ayaka Nagao Kanako Kojima Yusaku Miyata Tairo Kashihara Tomoya Kaneda Kana Takahashi Koji Inaba Kae Okuma Yuko Nakayama Hiroyuki Okamoto Mitsuya Ishikawa Hiroshi Igaki Source Type: research

3D-printed vaginal cylindrical template with curved needle channels in MRI-guided vaginal cuff brachytherapy
CONCLUSIONS: With careful pre-planning, 3D-PVCT provides good target coverage and sparing of OARs. The results from these two patients indicate that this approach is very promising due to its flexibility and potential widespread application in the future.PMID:38230399 | PMC:PMC10789162 | DOI:10.5114/jcb.2023.133227 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Zhuang Mao Hongfu Zhao Source Type: research

Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report
CONCLUSIONS: The dose ratio of the sigmoid colon to HR-CTV D90 was decreased by introducing a hydrogel spacer into the meso-sigmoid. In cases where the sigmoid colon is in proximity to the cervical tumor, this novel technique can be considered to achieve better clinical outcomes.PMID:38230404 | PMC:PMC10789158 | DOI:10.5114/jcb.2023.134174 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Madoka Sakuramachi Naoya Murakami Ayaka Nagao Kanako Kojima Yusaku Miyata Tairo Kashihara Tomoya Kaneda Kana Takahashi Koji Inaba Kae Okuma Yuko Nakayama Hiroyuki Okamoto Mitsuya Ishikawa Hiroshi Igaki Source Type: research

Clinical implementation of three-dimensional standardized template-guided brachytherapy for patients with locally advanced cervical cancer
CONCLUSIONS: The implementation of 3D standardized template can potentially improve the precision and consistency in the needle insertion procedure that may replace some customized 3D templates, and achieve clinical satisfied dose distribution in IC/ISBT plans for patients with LACC.PMID:38230396 | PMC:PMC10789161 | DOI:10.5114/jcb.2023.134170 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Yeqiang Tu Jiahao Wang Yukai Chen Yuanyuan Chen Qiu Tang Source Type: research

3D-printed vaginal cylindrical template with curved needle channels in MRI-guided vaginal cuff brachytherapy
CONCLUSIONS: With careful pre-planning, 3D-PVCT provides good target coverage and sparing of OARs. The results from these two patients indicate that this approach is very promising due to its flexibility and potential widespread application in the future.PMID:38230399 | PMC:PMC10789162 | DOI:10.5114/jcb.2023.133227 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Zhuang Mao Hongfu Zhao Source Type: research

Clinical implementation of three-dimensional standardized template-guided brachytherapy for patients with locally advanced cervical cancer
CONCLUSIONS: The implementation of 3D standardized template can potentially improve the precision and consistency in the needle insertion procedure that may replace some customized 3D templates, and achieve clinical satisfied dose distribution in IC/ISBT plans for patients with LACC.PMID:38230396 | PMC:PMC10789161 | DOI:10.5114/jcb.2023.134170 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Yeqiang Tu Jiahao Wang Yukai Chen Yuanyuan Chen Qiu Tang Source Type: research

3D-printed vaginal cylindrical template with curved needle channels in MRI-guided vaginal cuff brachytherapy
CONCLUSIONS: With careful pre-planning, 3D-PVCT provides good target coverage and sparing of OARs. The results from these two patients indicate that this approach is very promising due to its flexibility and potential widespread application in the future.PMID:38230399 | PMC:PMC10789162 | DOI:10.5114/jcb.2023.133227 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Zhuang Mao Hongfu Zhao Source Type: research

Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report
CONCLUSIONS: The dose ratio of the sigmoid colon to HR-CTV D90 was decreased by introducing a hydrogel spacer into the meso-sigmoid. In cases where the sigmoid colon is in proximity to the cervical tumor, this novel technique can be considered to achieve better clinical outcomes.PMID:38230404 | PMC:PMC10789158 | DOI:10.5114/jcb.2023.134174 (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - January 17, 2024 Category: Cancer & Oncology Authors: Madoka Sakuramachi Naoya Murakami Ayaka Nagao Kanako Kojima Yusaku Miyata Tairo Kashihara Tomoya Kaneda Kana Takahashi Koji Inaba Kae Okuma Yuko Nakayama Hiroyuki Okamoto Mitsuya Ishikawa Hiroshi Igaki Source Type: research

Cancers, Vol. 16, Pages 362: Hypofractionated Radiotherapy in Gynecologic Malignancies & mdash;A Peek into the Upcoming Evidence
Cancers, Vol. 16, Pages 362: Hypofractionated Radiotherapy in Gynecologic Malignancies—A Peek into the Upcoming Evidence Cancers doi: 10.3390/cancers16020362 Authors: Razan Amjad Nataliya Moldovan Hamid Raziee Eric Leung David D’Souza Lucas C. Mendez Radiotherapy (RT) has a fundamental role in the treatment of gynecologic malignancies, including cervical and uterine cancers. Hypofractionated RT has gained popularity in many cancer sites, boosted by technological advances in treatment delivery and image verification. Hypofractionated RT uptake was intensified during the COVID-19 pandemic and ha...
Source: Cancers - January 15, 2024 Category: Cancer & Oncology Authors: Razan Amjad Nataliya Moldovan Hamid Raziee Eric Leung David D ’Souza Lucas C. Mendez Tags: Review Source Type: research

A clinical solution for non-toxic 3D-printed photon blocks in external beam radiation therapy
CONCLUSIONS: This study validates a novel, efficient 3D-printing method for photon block creation in clinical settings. Despite potential limitations, the benefits include reduced manual labor, automated processes, and greater precision. It holds potential for widespread adoption in radiation therapy, furthering non-toxic radiation shielding.PMID:38213084 | DOI:10.1002/acm2.14225 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 12, 2024 Category: Physics Authors: Joseph B Schulz Piotr Dubrowski Clinton Gibson Amy S Yu Lawrie Basil Skinner Source Type: research

Take Your Best Shot Upfront!
For a pelvic recurrence of endometrial cancer, the standard of care is external beam radiation therapy (EBRT).1 Why? Many series and the yet-to-be-published GOG 0238 trial demonstrate the efficacy of EBRT alone. Klopp et al presented the findings of GOG 0238 at the International Gynecologic Cancer Society 2022 annual meeting.2 This was a randomized trial of radiation therapy for pelvic recurrence of endometrial cancer with and without chemotherapy. The trial took 13 years to accrue 157 patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2024 Category: Radiology Authors: Lindsay Burt, David Gaffney Tags: Gray Zone Source Type: research

Can Extreme Dose Escalation With External Beam Radiation Therapy and Low-Dose-Rate Brachytherapy Boost Obviate the Need for Long-Term Androgen Deprivation Therapy in Patients With High-Risk Localized Prostate Cancer?
Over the past 2 decades, long-term androgen deprivation therapy (ADT) has become a standard-of-care treatment recommendation for patients undergoing external beam radiation therapy (EBRT). Multiple randomized controlled trials involving EBRT1-4 have reported that long-term ADT reduced distant metastases and prostate cancer –specific mortality compared with short-term ADT. The TROG RADAR study even reported a benefit of long-term ADT in the EBRT + high-dose-rate brachytherapy boost stratification. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2024 Category: Radiology Authors: Martin T. King, Peter F. Orio, Anthony V. D'Amico Tags: Editorial Source Type: research

Nodal Recurrence of Uterine Cancer: A Growing Problem
GOG 258 was a negative trial because patients in the radiation cohort received less full-dose chemotherapy and had it delayed.1 This resulted in a 7% higher rate of distant metastasis in the radiation therapy group, offsetting the 13% improvement in locoregional control. Isolated vaginal relapse occurred in only 5% of patients treated with chemotherapy alone, whereas 14% had nodal relapse without distant relapse. This suggests there still may be a role for sequential adjuvant external beam radiation therapy (EBRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2024 Category: Radiology Authors: Scott Glaser Tags: Gray Zone Source Type: research

An Economic Analysis of SC24 in Canada: A Randomized Study of SBRT Compared with Conventional Palliative RT for Spinal Metastases
xx.xx was a multicenter randomized controlled phase 2/3 trial conducted in Canada and Australia. Patients with painful spinal metastases were randomized to either 24 Gy/2 stereotactic body radiotherapy (SBRT) or 20 Gy/5 conventional external beam radiotherapy (CRT). The study met its primary endpoint demonstrating superior complete pain response rates (CRR) at 3 months following SBRT (35%) vs CRT (14%). SBRT planning and delivery is resource intensive. Given its benefits in xx.xx, we performed an economic analysis to determine the incremental cost-effectiveness of SBRT compared to CRT. (Source: International Journal of Rad...
Source: International Journal of Radiation Oncology * Biology * Physics - January 11, 2024 Category: Radiology Authors: Marc Kerba, Richard De Abreu Lourenco, Arjun Sahgal, Rafael de Feria Cardet, Shankar Siva, Keyue Ding, Sten Myrehaug, Giuseppina L Masucci, Michael Brundage, Wendy R. Parulekar Tags: Brief Report Source Type: research

Multicentric assessment of safety and efficacy of combinatorial adjuvant brain metastasis treatment by intraoperative radiotherapy and immunotherapy
Following surgical resection of brain metastases (BMs), intraoperative radiation therapy (IORT) provides a promising alternative to adjuvant external beam radiation therapy (EBRT) by enabling superior organ at risk preservation, reduction of in-hospital times and timely admission to subsequent systemic treatments, which increasingly comprise novel targeted immunotherapeutic approaches. We sought to assess safety and efficacy of IORT in combination with immune checkpoint inhibitors (ICIs) and other targeted therapies (TTs). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 8, 2024 Category: Radiology Authors: Julian P. Layer, Ehab Shiban, Stefanie Brehmer, Christian D. Diehl, Douglas Guedes de Castro, Motaz Hamed, Cas S. Dejonckheere, Daniel T. Cifarelli, Lea L. Friker, Ulrich Herrlinger, Michael H ölzel, Hartmut Vatter, Matthias Schneider, Stephanie E. Combs Tags: Clinical Investigation Source Type: research