Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
This article was originally published on The Conversation. News in Context: Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging What are cognitive abilities and how to boost them? The post Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 14, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimer’s biological Brain-Fitness cognition cognitive engagement cognitive-abilities cognitive-reserve dementia depression exercise inflammation lifestyle neuroplasticity optimize cognition Stress Source Type: blogs

Top 6 Medical Trends To Watch for 2024
This study also reported a weight reduction of 4.0 kilograms and a 10.8-millimeter reduction in systolic blood pressure among patients. This segment is becoming significant in market terms as well: the market for DTx was valued at USD 5.53 billion in 2022 and is expected to grow to USD 28.66 billion by 2030. The increased prevalence of chronic conditions, as the result of our longer lives, fuels this growth as conditions like diabetes or hypertension can be more efficiently managed with a combination of traditional medicine and DTx.  While these apps are available in a large number of medical specialties, channe...
Source: The Medical Futurist - December 14, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Source Type: blogs

Abbott Gets Real About " Formulary Exclusions " Bankrolled by Rival Dexcom in the U.S.
My followers may recall that I ' ve written not-so-kind blog posts about how Dexcom paying legally-exempted rebate kickbacks (seehttps://blog.sstrumello.com/2023/06/dexcom-pays-pbms-kickbacks-to-exclude.html for one such blog post) to major Pharmacy Benefit Managers (PBMs) contingent upon " formulary exclusions of less costly rival continuous glucose monitoring (CGM) systems such as Abbott Freestyle Libre. The retail prices for both CGM sensor brands are remarkably close (ranging from $57.33/sensor to $61.28/sensor). However, the cost computation is not based on the cost per sensor, but must be computed on a cost per ...
Source: Scott's Web Log - December 14, 2023 Category: Endocrinology Tags: 2023 Abbott Freestyle Libre 3 coupons Dexcom PBM PBMs Source Type: blogs

Science Snippet: Zooming In on Nanoparticles
Nanoparticles come in many different shapes and configurations. Credit: Adapted from Stevens, et. al., under Creative Commons License 4.0. Nanoparticles may sound like gadgets from a science fiction movie, but they exist in real life. They’re particles of any material that are less than 100 nanometers (one-billionth of a meter) in all dimensions. Nanoparticles appear in nature, and humans have, mostly unknowingly, used them since ancient times. For example, hair dyeing in ancient Egypt involved lead sulfite nanoparticles, and artisans in the Middle Ages added gold and silver nanoparticles to stained-glass windows. Over...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Cool Videos Medicines Science Snippet Source Type: blogs

Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. « Back to ...
Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mari Ruddy and Extreme Healing
Today, I have the pleasure of sharing an incredibly inspiring conversation with one of my heroes, Mari Ruddy. If you are not familiar with Mari, buckle up – her story is one of profound resilience, strength, and healing. Like me, Mari lives with type 1 diabetes. She was diagnosed in 1981, and in addition to dealing with diabetes, Mari has also courageously overcome several other life challenges. Mari discovered her love for distance cycling at the age of 39. TeamWILD, one of the organizations she created, played a crucial role in my journey, and it...
Source: Scott's Diabetes Blog - December 10, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

Mari Ruddy and Extreme Healing
I sat down with Mari Ruddy, a tireless advocate, successful author, and my personal hero. Mari uses her experience to empower others facing similar challenges. In our discussion, we explore Mari's journey from discovering her love for distance cycling to writing her brilliant book, 'Extreme Healing'. Listen in as she shares the highs, the lows, her strategies for dealing with chronic illness, and her passion for endurance sports. You’ll also hear her personal challenges of conquering cancer and living with diabetes. But most importantly, you'll hear about the resilience, the courage, and the unyielding spirit that ha...
Source: Scott's Diabetes Blog - December 10, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

A Twin Study to Assess Short Term Cardiometabolic Health Benefits of a Vegan Diet
If you're familiar with discussion of veganism as a lifestyle choice, nothing in this material will all that surprising. Vegans tend towards lower calorie intake and the benefits resulting from that, and that may be the dominant effect when looking at commonly measured health metrics in vegan study participants. It would be interesting to see more comparison studies in which the vegans were held to the same calorie intake as the omnivore control participants, but, alas, that is logistically harder and thus not the approach chosen by most study organizers. Although it's well-known that eating less meat improves car...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The State Of CRISPR Clinical Trials And Their Future Potentials
CRISPR, short for “Clustered Regularly Interspaced Short Palindromic Repeats” – and more specifically CRISPR–Cas9 – relates to a gene-editing method that gained popularity in the past decade; and not for trivial reasons. Being the most efficient and accurate method to edit a cell’s genome, CRISPR holds potentials that range from treating conditions such as HIV to finding new drug targets. While such potentials are real and are being actively investigated, you might be curious about more practical examples of CRISPR applications. By taking the US Clinical Trials registry as an example, we consider lis...
Source: The Medical Futurist - December 7, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF CRISPR therapy clinical trials gene editing Source Type: blogs

Towards Drugs to Treat Sarcopenia
Here, researchers review present efforts to develop drugs to treat sarcopenia, the age-related loss of muscle mass and strength that occurs in every individual, leading to eventual frailty. As a snapshot of the research and development community, it is representative of efforts across age-related disease generally, in that the primary focus falls on more easily developed options that cannot possibly produce results larger than those resulting from exercise, particular resistance exercise. This is the unfortunate outcome of the present medical regulatory system, in which the costs of regulatory approval are made so high tha...
Source: Fight Aging! - December 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment. In today's open access paper, the authors make the interesting point ...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Most Overhyped Technologies in Healthcare
The hype about technological development in healthcare should not blind us in terms of the probabilities and possibilities of today’s healthcare and the future of medicine. To remain objective and conscious but still optimistic, let’s look at the most overhyped technologies and keep in mind the realistic development opportunities in healing. You know the saying: the pessimist says the glass is half empty, the optimist says it is half full, and, well, the cynic asks who drank the other half? I’m truly an optimist – especially when it comes to the future of medicine and healthcare, but we need to ask the uncom...
Source: The Medical Futurist - December 5, 2023 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine 3d printing robotics virtual reality wearables GC1 hype organs Source Type: blogs

Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice. In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Novo Nordisk to Discontinue Levemir in 2024
Upgrade to Patent-Protected Tresiba — or else!On Wednesday, November 8, 2023, Novo Nordisk announced that it would discontinue its long-acting insulin Levemir (insulin detemir injection) in the United States, citing manufacturing constraints, reduced patient access and available alternatives. The company ' s official statement (seehttps://www.novomedlink.com/diabetes/products/treatments/levemir.html) said: " We will continue to provide Levemir FlexPen and Levemir vials to wholesalers while supplies last, up to the discontinuation dates, but supply disruptions should be expected. "It added further: " Levemir FlexPen,...
Source: Scott's Web Log - November 29, 2023 Category: Endocrinology Tags: 2023 basal insulin diatribe discontinue insulin detemir Levemir Novo Nordisk Source Type: blogs