A Path to Increasing Glutathione Levels in Mitochondria
Glutathione is an interesting cellular antioxidant, as increased levels can improve health in humans and slow aging in animal models. You might recall recent small human trials of high dose supplementation of glutathione precursors in order to achieve upregulation of glutathione, and corresponding studies in mice. It is thought that glutathione upregulation may largely improve health via mitochondrial function, as mitochondria are a prominent source of oxidative stress in aging cells. Here, researchers find a mechanism that regulates the amount of glutathione that enters the mitochondria, and thus a possible target to incr...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Zealous for Wellness: How to Replace Hype with Data
This article begins a series that looks at useful measures of health and how the companies that promote wellness programs demonstrate their success. We’ll see measurements of objective outcomes, patient-reported outcomes, and what payers look for when they can’t get direct evidence of improvements in wellness.
You’ll note, as we survey the wellness solutions and measurements used, that the leading organizations in this space are payers, not clinicians. I’m sure that doctors and nurse practitioners truly care for the overall happiness and wellbeing of their patients. But the institutions aren’t...
Source: EMR and HIPAA - November 14, 2023 Category: Information Technology Authors: Andy Oram Tags: AI/Machine Learning Ambulatory Analytics/Big Data Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System LTPAC Telemedicine and Remote Monitoring ACOs Avanade Christiana Voelker Cli Source Type: blogs
Putting people in boxes
I just finished readingThe Invisible Kingdom: Reimagining Chronic Illness, by Meghan O ' Rourke. She lived for many years with a debilitating illness that went undiagnosed. She ultimately concluded that she had chronic sequelae of Lyme disease, likely complicated by autoimmune and other manifestations that may have been triggered by Lyme disease or possibly just co-occurring coincidentally. In her desperation to find relief, or at least answers, she saw innumerable physicians and other practitioners, ultimately resorting to people with, shall we say, unorthodox ideas who many people -- I included -- would classify as quack...
Source: Stayin' Alive - November 13, 2023 Category: American Health Source Type: blogs
How confident are clinicians to deliver pain self-management?
Over the past few weeks I’ve been talking about pain self management from many perspectives. It’s an important topic because most people living with pain will be self managing most of the time. Being able to confidently self manage leads to less disability, distress and lives that look like life, not some endless healthcare regime.
A paper by Penlington et al., (2023) explored confidence beliefs of clinicians working in the UK in primary or community settings prior to a training programme that was then delivered to them. The sample included in the survey is therefore a subset of those who might be expected t...
Source: HealthSkills Weblog - November 12, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping Skills Coping strategies Pain conditions Research Science in practice Health healthcare pain management Therapeutic approaches Source Type: blogs
Bonus Features – November 12, 2023 – 93% of clinicians use RPM in cardiac care rehab, telehealth flexibilities remain in place until the end of 2024, plus 25 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The 2024 Medicare Physician Fee Schedule continues many telehealth flexibilities first adopted during the public health emergency, such as an expanded scope of originating sites an expanded definition of qualified practiti...
Source: EMR and HIPAA - November 12, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT 1upHealth Apollo ApolloMed Cedar Cognoa CPSI Deloitte Technology Fast 500™ emtelligent Freshpaint Healthcare IT Today Bonus Features HITRUST Certification Hona Innovaccer Inovalon Jim Hundemer Jim Sparks K Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Emergency department burnout: a cry for change
It’s a busy day in the emergency department. The waiting room is full, and we are short-staffed. I just read an email from administration that morning about how our treat and release times are “slipping,” and in the same breath, they remind us of the importance of patient satisfaction. There are many patients in the
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Emergency department burnout: a cry for change originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 11, 2023 Category: General Medicine Authors: Anonymous Tags: Conditions Diabetes Source Type: blogs
The Immune System Mediates Some of the Benefits of Exercise
It is uncontroversial to point out that exercise is good for long-term health. It slows aging, reduces risk of age-related disease, reduces mortality. A mountain of evidence supports these assertions, both animal studies demonstrating causation, and any number of large human studies showing correlation. Exercise, like the practice of calorie restriction, produces sweeping changes in the operation of metabolism. Near everything is different, both in the short term following exercise, and over the long term when looking at differences between the biochemistry of a fit individual versus that a sedentary individual. This can m...
Source: Fight Aging! - November 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Rosuvastatin or Atorvastatin , Which is good and safe ?
Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry.
Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically establishe...
Source: Dr.S.Venkatesan MD - November 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs
What we have to gain from weight loss drugs
Twenty years ago, the headlines were grim. It was common for studies to warn: “Rising childhood obesity will decrease life expectancy.” In large part, those predictions came true. The rise in obesity – both in children and adults – has correlated to a catastrophic rise in chronic disease that continues to affect life expectancy, cost
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What we have to gain from weight loss drugs originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 9, 2023 Category: General Medicine Authors: Hoag Memorial Hospital Presbyterian Tags: Conditions Endocrinology Source Type: blogs
Magnetic Dressing Improves Diabetic Wound Healing
Researchers at the National University of Singapore have developed a magneto-responsive hydrogel wound dressing that also contains two different regenerative cell types. The hydrogel is also embedded with magnetic particles that can be stimulated using an external magnetic field. The action of the magnetic field on the gel-encapsulated particles causes mechanical stresses within the gel to act on the cells, stimulating them to grow and enhancing their regenerative potential. The advanced dressing is intended to assist in healing diabetic wounds, which can be difficult to treat.
In diabetes, various issues can impair wou...
Source: Medgadget - November 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Surgery diabetic wound hydrogel NUSingapore Source Type: blogs
The Role of Senescent Cells in Age-Related Skeletal Diseases
Compelling evidence obtained from many studies in mice show that the accumulation of senescent cells with age is a major contributing factor in all of the common, inflammatory age-related conditions: cardiovascular disease, dementia, degeneration of bone tissue, and so forth. Senescent cells are created throughout life, mostly as somatic cells reach the Hayflick limit on replication, but accumulate in later life in large part because the immune system falters in its clearance of senescent cells. It still performs this function, but less efficiently, and the balance between creation and destruction of senescent cells tips t...
Source: Fight Aging! - November 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
PhaseV Raises $15 Million to Push the Boundaries of ML for Clinical Trial Optimization
Clinical Trial Platform Uncovers Hidden Signals and Optimizes Next Steps for More Adaptive, Successful, and Efficient Clinical Trials
PhaseV, a pioneer in causal machine learning (ML) technology that optimizes clinical trial design and analysis, announced today that it has raised $15 million in funding, led by Viola Ventures and Exor Ventures, including participation from LionBird and a group of prominent angel investors.
A recent Deloitte study estimates the average cost of developing a single new drug at $2.3 billion in 2022, with an average 7.1-year deployment time. Moreover, the vast majority of drug candidates do...
Source: EMR and HIPAA - November 7, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Deloitte Dr. Brad Carlin Dr. Dan Goldstaub Dr. David Perry Dr. Howard Trachtman Dr. Marcia Levenstein Dr. Miriam Kidron Dr. Murray B. Urowitz Dr. Raviv Pryluk Dr. Sofia Vilar Elad Berkman Exor Vent Source Type: blogs
3D Printing In Medicine And Healthcare – The Ultimate List
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. See the impressive list of 3D-printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of Buffalo have ...
Source: The Medical Futurist - November 7, 2023 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine 3d printed biomaterial tissue engineering Video bioprinting GC1 Innovation Source Type: blogs
Reviewing the Role of Cellular Senescence in Metabolic Disease
Senescent cells accumulate with age throughout the body. In youth the immune system promptly removes senescent cells, but this clearance slows with advancing age, leading to a growing population of lingering senescent cells. Senescent cells cease replicating and devote their efforts to the production of pro-growth, pro-inflammatory signals that become disruptive to tissue structure and function. Thus a population of senescent cells acts to actively maintain a degraded state of tissue, and their removal is immediately beneficial. Mouse studies show compelling, rapid reversals of age-related disease and extended life span re...
Source: Fight Aging! - November 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
