Considering the Near Future of Senotherapeutics
Senescent cells accumulate with age, and this accumulation drives a sizable fraction of the dysfunction of degenerative aging. While never present in very large numbers, these cells energetically secrete signal molecules that provoke inflammation and tissue remodeling. As noted here, a major theme in the development of senotherapeutic drugs to either selectively destroy senescent cells or broadly suppress the disruptive signaling of senescent cells is the need for greater understanding of the diversity of cellular senescence. Different tissues, different cell types, different origins of the senescent state may all be meani...
Source: Fight Aging! - February 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Patient Advocates Argue Exercising Bayh-Dole " March-In " Rights Reasonable to Ensure Ongoing Supply of an Insulin Novo Nordisk Intends to Discontinue
Back in 2016 (when President Obama was still in office), the trade group known as the Pharmaceutical Research and Manufacturers of America (better known by the acronym PhRMA) claimed in an organization-published white paper (seehttps://web.archive.org/web/20161022175500/https://phrma.org/sites/default/files/pdf/bayh-dole-act-white-paper-summary.pdf for an archived copy of that paper from PhRMA; note that it has since been removed from PhRMA ' s website, hence I found a copy on the Internet Archive) that championed the Bayh-Dole Act of 1980. Understand that what PhRMA really wants to prevent a particular provision...
Source: Scott's Web Log - February 11, 2024 Category: Endocrinology Tags: march-in rights 2024 Alliance to Protect Insulin Choice APIC Bayh-Dole insulin detemir Levemir Novo Nordisk Source Type: blogs

There ’s no place like home when it comes to health care, except for those who fall through the cracks
Maria (name changed to protect patient privacy) is a brilliant woman with a troubled health history. After a mental health diagnosis cut short her career as a high-level government official, Maria has struggled with diabetes, peripheral neuropathy, depression, and advanced kidney disease, leading to a series of toe amputations and a decade of disability. She Read more… There’s no place like home when it comes to health care, except for those who fall through the cracks originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 9, 2024 Category: General Medicine Authors: Tags: Conditions Primary Care Source Type: blogs

The Money ’ s in the Wrong Place. How to Fund Primary Care
By MATTHEW HOLT I was invited on the Health Tech Talk Show by Kat McDavitt and Lisa Bari and I kinda ranted (go to 37.16 here) about why we don’t have primary care, and where we should find the money to fix it. I finally got around to writing it up. It’s a rant but a rant with a point! We’re spending way too much money on stuff that is the wrong thing. 30 years ago, I was taught that we were going to have universal health care reform. And then we were going to have capitated at-risk entities. then below that, you have all these tech enabled services, which are going to make all this stuff work an...
Source: The Health Care Blog - February 5, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt ACA ACO CVS FQHCs Health Systems hedge funds Hospitals Medisync primary care Walgreens Walmart Source Type: blogs

FREE safe driving program for teens with diabetes
Free event for T1D teens! A safe driving program specifically designed for teens with diabetes on March 2, 2024 near Phoenix, ZA Register FREE! Download (PDF, 787KB) The post FREE safe driving program for teens with diabetes appeared first on Scott's Diabetes. (Source: Scott's Diabetes Blog)
Source: Scott's Diabetes Blog - February 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

FREE safe driving program for teens with diabetes
Sharing an AWESOME opportunity for teens with diabetes near Chandler, AZ on Saturday, March 2! The professionals at Radford Racing School are helping JDNL host the upcoming Check B4U Drive - 2024 session - a safe driving clinic for teens with diabetes! (Source: Scott's Diabetes Blog)
Source: Scott's Diabetes Blog - February 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

5 Insights Of The Medical Futurist ’ s 100 Digital Health And AI Companies Of 2024
We are proud to introduce The Medical Futurist’s 100 Digital Health And AI Companies Of 2024 infographic. We create this list year after year and it is always among our most popular, most shared visuals. Our aim here is not to create a ranking, nor a toplist, but to highlight companies to watch this year. The reason to publish this list is simple: the digital health realm is saturated with hype, distinguishing the promising players from the noise is a challenge. The annual list is our way of cutting through the clamor to spotlight those we believe are genuinely making strides in this space. Disclosure Just l...
Source: The Medical Futurist - February 1, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Digital Health Research top 100 Source Type: blogs

How to make the diagnosis of type 2 diabetes less difficult
Conclusion Being diagnosed with type 2 diabetes is undoubtedly an overwhelming experience. However, healthcare providers can make a significant difference by acknowledging and addressing the emotional challenges. Engaging in collaborative conversations, offering support, and providing helpful resources can empower people to manage their diabetes and see it is possible to live a long and healthy life with diabetes.Thanks for joining us today, and remember – you are not alone in your diabetes journey. ...
Source: Scott's Diabetes Blog - February 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

How to make the diagnosis of type 2 diabetes less difficult
This episode of BDI Briefs explores the emotional side of type 2 diabetes diagnosis with Dr. Polonsky and Dr. Guzman. It is a critical moment that can reverberate for years and set the tone for diabetes management. We emphasize the need for healthcare providers to address the strong negative emotions patients face, encourage hope, and provide resources like the "Don't Freak Out Booklet" to hopefully create a better diagnosis experience for people with diabetes. (Source: Scott's Diabetes Blog)
Source: Scott's Diabetes Blog - February 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

Putting West Virginia Students on the Path to Scientific Careers
Credit: NIGMS. Two NIGMS-funded programs are teaming up to shape the future of science and technology in West Virginia (WV). One engages high school students in science, technology, engineering, math, and medicine (STEM+M); introduces them to research; and provides direct access to college through tuition waivers. In the other program, undergraduate students are paired with a researcher at their institution for a paid internship—an important step toward a career in science. The Health Sciences & Technology Academy “We liken our students to rosebuds. As they grow, you see them blossom into self-confident lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 31, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education SEPA Training Source Type: blogs

Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A talk with Andy Bell on thriving with diabetes
Andy Bell:Experiencing diabetes beyond just numbers I recently had the privilege of catching up with Andy Bell. A good friend and part of the diabetes community, Andy shared his story, which is packed with perseverance and resilience.Andy was diagnosed with type 1 diabetes in 1994 at the age of 14. His experience, like that of many others living with diabetes, has been a rollercoaster ride. During our conversation, Andy touched on his diagnosis story, how living with diabetes has impacted his life, his unique career path, and how he manages now that heâ€...
Source: Scott's Diabetes Blog - January 26, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

A talk with Andy Bell on thriving with diabetes
Andy Bell, diagnosed with type 1 diabetes at 14, shares his story of resilience, navigating life beyond diabetes to become a personal trainer, JDRF employee, law enforcement officer, black belt in jiu-jitsu, yoga instructor, father, and more. Recently diagnosed with another autoimmune disease, Addison's, Andy continues to embody determination and hope. Join me to learn more about his fascinating story. (Source: Scott's Diabetes Blog)
Source: Scott's Diabetes Blog - January 26, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

The Business Case for a Biosimilar Company to Bring a Copy of Levemir to Market
My readers may recall that in November 2023, I blogged that Novo Nordisk announced it plans to retire (stop making) its first " Lantus killer " known as Levemir (insulin detemir injection) in the U.S. in 2024 (catch my post at https://blog.sstrumello.com/2023/11/novo-nordisk-to-discontinue-levemir-in.html for more). At the time I learned of the announcement, I was on vacation in Amsterdam, so I just made a note of the development and blogged about it a few weeks later upon my return.Like other patients my age, I have endured the company ' s previous insulin " retirements " . Novo Nordisk ' s time-frame for withdr...
Source: Scott's Web Log - January 25, 2024 Category: Endocrinology Tags: 2024 Biosimilar Levemir Novo Nordisk PBM Source Type: blogs

Acute chest pain in a patient with LVH and known coronary disease. What does the ECG show?
A 40-something with severe diabetes on dialysis and with known coronary disease presented with acute crushing chest pain.Here is his ED ECG:What do you think?There is a flat and downsloping ST segment in V2 and V3.  This could be due to posterior OMI.  Is there an old ECG for comparison?Here is the most recent previous ECG:Indeed, there was some normal ST elevation in V2 and V3, discordant to a relatively deep S-wave which could be due to some LVH.Here is another previous ECG:So it looks like a posterior OMI.2 years prior he had an angiogram which showed 90% proximal stenosis of the circumflex.  It...
Source: Dr. Smith's ECG Blog - January 25, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs