Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota
This study aimed to investigate the effects of paeoniflorin on OIPN and probe into the underlying mechanisms. The OIPN model was established through oxaliplatin injection in rats. The ameliorative effects of paeoniflorin on OIPN was assessed by nociceptive hypersensitivities through pain behavioral methods. Neuroinflammation were examined by measuring the levels of inflammatory cytokines and immune cells infiltration. The signaling pathway of TLR4/MyD88/NF-κB was evaluated by Western blotting. Gut microbial changes were detected by 16S rDNA sequencing technology. In addition, antibiotics-induced microbiota eradication and...
Source: European Journal of Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Jiayue Xu Langqing Lu Shiqin Jiang Zhiyan Qin Junyuan Huang Min Huang Jing Jin Source Type: research
Prevention of allergic reactions during oxaliplatin desensitization through inhibition of Bruton ’s tyrosine kinase
Capsule Summary: Acalabrutinib 100 mg orally twice daily starting in the evening 2 days before and continuing through a rapid drug desensitization protocol allowed a sensitized patient to successfully and safely receive oxaliplatin. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Kristin A. Erickson, James E. Norton, Jennifer Law, Nicole Soriano, Malgorzata Strojny, Nicole Gentry, Morgan Fried, Bruce S. Bochner, Sheetal Kircher, Whitney W. Stevens Source Type: research
Lycium barbarum polysaccharide reverses drug resistance in oxaliplatin-resistant colon cancer cells by inhibiting PI3K/AKT-dependent phosphomannose isomerase
Objective: Here, we aimed to explore the effect of LBP in combination with Oxaliplatin (OXA) on reversing drug resistance in colon cancer cells through in vitro and in vivo experiments. We also aimed to explore the possible mechanism underlying this effect. Finally, we aimed to determine potential targets of Lycium barbarum polysaccharide (LBP) in colon cancer (CC) through network pharmacology and molecular docking.Methods: The invasion ability of colon cancer cells was assessed using the invasion assay. The migration ability of these cells was assessed using the migration assay and wound healing assay. Cell cycle analysis...
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research
Prevention of allergic reactions during oxaliplatin desensitization through inhibition of Bruton tyrosine kinase
Acute infusion reactions to oxaliplatin, a chemotherapeutic used to treat gastrointestinal cancers, are observed in about 20% of patients. Rapid drug desensitization (RDD) protocols often allow the continuation of oxaliplatin in patients with no alternative options. Breakthrough symptoms, including anaphylaxis, can still occur during RDD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Kristin A. Erickson, James E. Norton, Jennifer Law, Nicole Soriano, Malgorzata Strojny, Nicole Gentry, Morgan Fried, Bruce S. Bochner, Sheetal Kircher, Whitney W. Stevens Tags: Brief report Source Type: research
Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1
Res Sq [Preprint]. 2024 Mar 5:rs.3.rs-4009459. doi: 10.21203/rs.3.rs-4009459/v1.ABSTRACTCisplatin and oxaliplatin cause the secretion of high mobility group box 1 (HMGB1) from cancer cells, which is necessary for initiation of immunogenic cell death (ICD). Calreticulin (CRT) translocation from the endoplasmic reticulum to the plasma membrane is also required; oxaliplatin induces this translocation but cisplatin does not. We have discovered that oxaliplatin causes the secretion of both HMGB1 and HMGB2 from the nucleus into the extracellular milieu. We previously showed that cisplatin mediated secretion of HMGB1 is controlle...
Source: Cell Research - March 18, 2024 Category: Cytology Authors: Ian Blair Jingqi Fan Kevin Gillespie Clementina Mesaros Source Type: research
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
J Inorg Biochem. 2024 Mar 1;254:112515. doi: 10.1016/j.jinorgbio.2024.112515. Online ahead of print.ABSTRACTChemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effe...
Source: Journal of Inorganic Biochemistry - March 15, 2024 Category: Biochemistry Authors: Tangli Wei Lihua Chen Pengmin Shi Changli Wang Yusheng Peng Jing Yang Xiali Liao Bo Yang Chuanzhu Gao Source Type: research
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
J Inorg Biochem. 2024 Mar 1;254:112515. doi: 10.1016/j.jinorgbio.2024.112515. Online ahead of print.ABSTRACTChemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effe...
Source: Journal of Inorganic Biochemistry - March 15, 2024 Category: Biochemistry Authors: Tangli Wei Lihua Chen Pengmin Shi Changli Wang Yusheng Peng Jing Yang Xiali Liao Bo Yang Chuanzhu Gao Source Type: research
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
J Inorg Biochem. 2024 Mar 1;254:112515. doi: 10.1016/j.jinorgbio.2024.112515. Online ahead of print.ABSTRACTChemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effe...
Source: Journal of Inorganic Biochemistry - March 15, 2024 Category: Biochemistry Authors: Tangli Wei Lihua Chen Pengmin Shi Changli Wang Yusheng Peng Jing Yang Xiali Liao Bo Yang Chuanzhu Gao Source Type: research
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
J Inorg Biochem. 2024 Mar 1;254:112515. doi: 10.1016/j.jinorgbio.2024.112515. Online ahead of print.ABSTRACTChemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effe...
Source: Journal of Inorganic Biochemistry - March 15, 2024 Category: Biochemistry Authors: Tangli Wei Lihua Chen Pengmin Shi Changli Wang Yusheng Peng Jing Yang Xiali Liao Bo Yang Chuanzhu Gao Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
