Which chemotherapeutic agent is well known to cause coronary vasospasm?
5-fluorouracil is well known to cause coronary vasospasm. 5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrhythmia or even sudden death can occur in up to 5% of patients. Vascular toxicity occurs generally within 72 hours of the...
Source: Cardiophile MD - November 13, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Red Light Activated Cancer Drug Improves Treatment in Mice
Researchers from the City University of Hong Kong have developed a new, controllable cancer drug called phorbiplatin that only becomes active and potent after red light stimulation. Their work demonstrates that in the dark the cancer drug does not have substantial toxicity, but the drug is able to substantially reduce tumor size when activated by red light. One day, this technology may be used to improve cancer treatment and reduce its side effects.
Currently, many cancer drugs are administered and have toxic effects on both cancer cells and our body’s healthy cells. This leads to incredibly challenging side effects ...
Source: Medgadget - October 7, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Oncology Source Type: blogs
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent well known to cause coronary vasospasm:Correct answer: c) 5-fluorouracil
5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrh...
Source: Cardiophile MD - February 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
MKSAP: 58-year-old man with cancer of the ascending colon
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 58-year-old man undergoes follow-up evaluation for cancer of the ascending colon diagnosed 3 weeks ago. Colonoscopy at that time revealed a fungating mass in the ascending colon. Biopsy revealed adenocarcinoma, and additional studies showed no evidence of metastatic disease. Right hemicolectomy was performed. The pathology report showed a 4-cm primary adenocarcinoma with clear margins at resection, full-thickness penetration through the colonic wall into pericolonic fat, and 4/21 lymph nodes involved (stage II...
Source: Kevin, M.D. - Medical Weblog - August 26, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Nanoparticles Made of Building Blocks Integrate Multiple Chemo Agents
Researchers at MIT have developed a method of creating nanoparticles that can carry three or more different chemo drugs simultaneously into a tumor. Moreover, in an unusual twist, it seems like the drugs ended up acting differently than when delivered systemically, pointing to the delivery method affecting how a medication actually behaves. “People tend to take it as a given that when you put a drug into a nanoparticle it’s the same drug, just in a nanoparticle,” said Jeremiah Johnson, associate professor of chemistry at MIT in a statement. “Here, in collaboration with Mike Hemann [associate professor of biolog...
Source: Medgadget - September 21, 2016 Category: Medical Equipment Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs
An interesting case
SAN DIEGO — A La Jolla oncologist was sentenced in San Diego federal court Tuesday to a year of probation, stemming from a scheme in which he and his practice treated patients with unapproved foreign cancer drugs, then fraudulently billed Medicare $1.7 million.Dr. Joel I. Bernstein’s sentence is in addition to the one his medical corporation received Friday. His practice was ordered to pay a $500,000 fine, forfeit $1.2 million and make restitution to Medicare for $1.7 million.The payments have all been paid, said his attorney, Charles Sevilla.A federal judge also sentenced the practice to a year of probation, mean...
Source: PharmaGossip - July 3, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs
2012: Banner Year for New Drugs
Fueled by new cancer therapeutics, last year the annual new molecular and biological entity approval count from the U.S. Food and Drug Administration (FDA) saw its highest year since 1997. One-third of the novel products approved by the FDA’s Center for Drug Evaluation and Research (CDER) are used to treat cancers of the blood, breast, colon, prostate, skin and thyroid.
As part of the U.S. Food and Drug Administration (FDA), the Center for Drug Evaluation and Research (CDER) promotes and protects the health of Americans by assuring that all prescription and over-the-counter drugs are safe and effective. The CDE...
Source: Highlight HEALTH - February 13, 2013 Category: Medical Scientists Authors: Walter Jessen, Ph.D. Source Type: blogs
Successful colon cancer treatment
Jim’s son successful colon cancer treatment includes colon cancer chemotherapy – Oxaliplatin & Xeloda – and alternative cancer treatments given by a family member practitioner: an oncology nurse with an Msc. in cancer nursing. Stage iv colon cancer Jim’s son has stage iv colon cancer spread to liver and lungs, a loving […] (Source: Metastatic liver cancer)
Source: Metastatic liver cancer - February 4, 2009 Category: Cancer Authors: Kim Tags: Jim's son metastatic liver cancer survivor CANCER TREATMENT Colon Cancer colon cancer treatment oxaliplatin secondary liver cancer. cancer treatment options stage iv colon cancer xeloda Source Type: blogs
