Should Cytoreductive Surgery Alone for Peritoneal Metastases of Colorectal Origin be Centralized? A National Study of 4159 Procedures
CONCLUSIONS: Centralization of CRS alone should improve patient selection as well as FTR and POM. After P7, CRS/HIPEC decreased mostly in Cancer centers, without any impact on the number of CRS-alone cases referred to expert centers.PMID:38549002 | DOI:10.1245/s10434-024-15180-5 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2024 Category: Cancer & Oncology Authors: Barbara Noiret Xavier Lenne Am élie Bruandet Guillaume Piessen Clarisse Eveno Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Should Cytoreductive Surgery Alone for Peritoneal Metastases of Colorectal Origin be Centralized? A National Study of 4159 Procedures
CONCLUSIONS: Centralization of CRS alone should improve patient selection as well as FTR and POM. After P7, CRS/HIPEC decreased mostly in Cancer centers, without any impact on the number of CRS-alone cases referred to expert centers.PMID:38549002 | DOI:10.1245/s10434-024-15180-5 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2024 Category: Cancer & Oncology Authors: Barbara Noiret Xavier Lenne Am élie Bruandet Guillaume Piessen Clarisse Eveno Source Type: research
Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis
Eur J Pharmacol. 2024 Mar 27:176538. doi: 10.1016/j.ejphar.2024.176538. Online ahead of print.ABSTRACTChemotherapy is one of the primary and indispensable intervention against cancers though it is always accompanied by severe side effects especially cachexia. Cachexia is a fatal metabolic disorder syndrome, mainly characterized by muscle loss. Oxidative stress is the key factor that trigger cachectic muscle loss by inducing imbalance in protein metabolism and apoptosis. Here, we showed an oral compound (Z526) exhibited potent alleviating effects on C2C12 myotube atrophy induced by various chemotherapeutic agents in vitro a...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaofan Gu Shanshan Lu Meng Fan Shuang Xu Guangyu Lin Yun Zhao Weili Zhao Xuan Liu Xiaochun Dong Xiongwen Zhang Source Type: research
13-oxyingenol dodecanoate derivatives induce mitophagy and ferroptosis through targeting TMBIM6 as potential anti-NSCLC agents
Eur J Med Chem. 2024 Mar 24;270:116312. doi: 10.1016/j.ejmech.2024.116312. Online ahead of print.ABSTRACTIngenol diterpenoids continue to attract the attention for their extensive biological activity and novel structural features. To further explore this type of compound as anti-tumor agent, 13-oxyingenol dodecanoate (13-OD) was prepared by a standard chemical transformation from an Euphorbia kansui extract, and 29 derivatives were synthesized through parent 13-OD. Their inhibition activities against different types of cancer were screened and some derivatives showed superior anti-non-small cell lung cancer (NSCLC) cells c...
Source: European Journal of Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Yaxu Wang Liwei Gu Jichong Li Ruqi Wang Yuan Zhuang Xiangyun Li Xinye Wang Junzhe Zhang Qingbo Liu Jigang Wang Shao-Jiang Song Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis
Eur J Pharmacol. 2024 Mar 27:176538. doi: 10.1016/j.ejphar.2024.176538. Online ahead of print.ABSTRACTChemotherapy is one of the primary and indispensable intervention against cancers though it is always accompanied by severe side effects especially cachexia. Cachexia is a fatal metabolic disorder syndrome, mainly characterized by muscle loss. Oxidative stress is the key factor that trigger cachectic muscle loss by inducing imbalance in protein metabolism and apoptosis. Here, we showed an oral compound (Z526) exhibited potent alleviating effects on C2C12 myotube atrophy induced by various chemotherapeutic agents in vitro a...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaofan Gu Shanshan Lu Meng Fan Shuang Xu Guangyu Lin Yun Zhao Weili Zhao Xuan Liu Xiaochun Dong Xiongwen Zhang Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Quma Tongluo Prescription in the Treatment of Chronic Oxaliplatin Related Peripheral Neuropathy: A Single-Center, Open, Randomized Controlled Study
CONCLUSIONS: Quma Tongluo decoction can effectively treat oxaliplatin-related chronic peripheral neuropathy, reduce the symptoms while reducing the scope of symptoms, and has no obvious adverse reactions in clinical practice, with good safety.PMID:38551443 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jianing Jia Yi Yang Chuan Shi Meilu Du Yufei Tang Xiaoling Yin Fenggang Hou Source Type: research
Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer
CONCLUSIONS: Our evidence suggests that sphingolipid metabolism is dysregulated in PDAC. Furthermore, S1P inhibition can sensitize PDAC to Oxa therapy through increasing ER stress and can potentiate ICD induction. This highlights a potential therapeutic target for chemosensitizing PDAC as well as an adjunct for future chemoimmunotherapy strategies.PMID:38545484 | PMC:PMC10965266 | DOI:10.14740/wjon1768 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Zachary Gao Harinarayanan Janakiraman Yang Xiao Sung Wook Kang Jiangling Dong Jasmine Choi Besim Ogretmen Hyun-Sung Lee Ernest Ramsay Camp Source Type: research
Cancers, Vol. 16, Pages 1291: Perioperative Chemotherapy for Gastro-Esophageal or Gastric Cancer: Anthracyclin Triplets versus FLOT
Conclusion(s): Real-world data showed no significant OS improvement for FLOT-treated patients compared to anthracyclin triplets, despite more staging laparoscopies. However, FLOT patients demonstrated higher rates of neoadjuvant therapy completion, proceeding to adjuvant therapy, and increased pCR rates. Therefore, we recommend the continued use of neoadjuvant FLOT therapy in the current clinical setting. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Julie F. M. Geerts Charl ène J. van der Zijden Pieter C. van der Sluis Manon C. W. Spaander Grard A. P. Nieuwenhuijzen Camiel Rosman Hanneke W. M. van Laarhoven Rob H. A. Verhoeven Bas P. L. Wijnhoven Sjoerd M. Lagarde Bianca Mostert Tags: Article Source Type: research
Efficacy and safety of natural killer cells injection combined with XELOX chemotherapy in postoperative patients with stage III colorectal cancer in China: a prospective randomised controlled clinical trial study protocol
Background
Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery.
Methods and analysis
This is a prospective, randomised contro...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Geng, S., Yu, X., Yu, S. Tags: Open access, Oncology Source Type: research
S100A6 mediated epithelial-mesenchymal transition affects chemosensitivity of colorectal cancer to oxaliplatin
CONCLUSION: In conclusion, the knockdown of S100A6 may overcome the L-OHP resistance of CRC cells by modulating EMT.PMID:38521111 | DOI:10.1016/j.gene.2024.148406 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Chunying Zhang Menglu Zeng Yihan Xu Bihan Huang Pengchong Shi Xianjin Zhu Yingping Cao Source Type: research
