Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis
CONCLUSIONS: The number of LCs performed, intraoperative cholangiography use and conversion rates were higher at ACs whereas bile duct injury and reoperation rates were higher at PCs. Despite a higher incidence of bile duct injury at PCs, the incidence at both PCs and ACs was <1%. In complex cases, a joint operation by both paediatric and adult surgeons might be a better approach to further improve outcomes. Overall, LC was found to be a safe operation with comparable outcomes at PCs and ACs.PMID:38445605 | DOI:10.1308/rcsann.2023.0041 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 6, 2024 Category: Surgery Authors: A Sinha A Mattson I Njere C K Sinha Source Type: research
Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis
CONCLUSIONS: The number of LCs performed, intraoperative cholangiography use and conversion rates were higher at ACs whereas bile duct injury and reoperation rates were higher at PCs. Despite a higher incidence of bile duct injury at PCs, the incidence at both PCs and ACs was <1%. In complex cases, a joint operation by both paediatric and adult surgeons might be a better approach to further improve outcomes. Overall, LC was found to be a safe operation with comparable outcomes at PCs and ACs.PMID:38445605 | DOI:10.1308/rcsann.2023.0041 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 6, 2024 Category: Surgery Authors: A Sinha A Mattson I Njere C K Sinha Source Type: research
Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis
CONCLUSIONS: The number of LCs performed, intraoperative cholangiography use and conversion rates were higher at ACs whereas bile duct injury and reoperation rates were higher at PCs. Despite a higher incidence of bile duct injury at PCs, the incidence at both PCs and ACs was <1%. In complex cases, a joint operation by both paediatric and adult surgeons might be a better approach to further improve outcomes. Overall, LC was found to be a safe operation with comparable outcomes at PCs and ACs.PMID:38445605 | DOI:10.1308/rcsann.2023.0041 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 6, 2024 Category: Surgery Authors: A Sinha A Mattson I Njere C K Sinha Source Type: research
Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis
CONCLUSIONS: The number of LCs performed, intraoperative cholangiography use and conversion rates were higher at ACs whereas bile duct injury and reoperation rates were higher at PCs. Despite a higher incidence of bile duct injury at PCs, the incidence at both PCs and ACs was <1%. In complex cases, a joint operation by both paediatric and adult surgeons might be a better approach to further improve outcomes. Overall, LC was found to be a safe operation with comparable outcomes at PCs and ACs.PMID:38445605 | DOI:10.1308/rcsann.2023.0041 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 6, 2024 Category: Surgery Authors: A Sinha A Mattson I Njere C K Sinha Source Type: research
Case report: Rapid recovery after intrathecal rituximab administration in refractory anti-NMDA receptor encephalitis: report of two cases
ConclusionOur cases provide evidence supporting the intrathecal administration of rituximab as a therapeutic option for patients with refractory anti-NMDAR encephalitis. Considering the limited penetration of intravenous rituximab into the central nervous system, a plausible argument can be made favoring intrathecal administration as the preferred route or the simultaneous administration of intravenous and intrathecal rituximab. This proposition warrants thorough investigation in subsequent clinical trials. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 6, 2024 Category: Allergy & Immunology Source Type: research
Bilateral primary motor area intermittent theta-burst stimulation may alleviate gait and postural disturbances in Parkinson's disease patients by astrocytic modulation, caudate volume changes, and increased functional neuroplasticity
Axial signs, such as gait disturbances and postural abnormalities, are common symptoms in advanced Parkinson's disease (PD). Postural instability is closely linked with both gait and balance dysfunction, and these conditions are directly related to the risk of falls. Compared to dyskinesia and motor complications, gait and postural dysfunctions are some of the most disabling symptoms for individuals with PD and are a major contributor to loss of autonomy and diminished quality of life. In addition, debilitating axial symptoms are common as the condition progresses, result in a substantial reduction in the therapeutic respo...
Source: Parkinsonism and Related Disorders - March 6, 2024 Category: Neurology Authors: Ra úl Rashid-López, Paloma Macías-García, Álvaro J. Cruz-Gómez, Francisco L. Sánchez-Fernández, Fátima Cano-Cano, Florencia Sanmartino, Esteban Sarrias-Arrabal, Elena Lozano-Soto, Constantino Méndez-Bértolo, Fernando López-Sosa, Álvaro Gonzá Tags: Correspondence Source Type: research
Retraction Notice to "Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis" [Neuropharmacology, 107 (2016) 432 - 450]
Neuropharmacology. 2024 Mar 4:109894. doi: 10.1016/j.neuropharm.2024.109894. Online ahead of print.NO ABSTRACTPMID:38443226 | DOI:10.1016/j.neuropharm.2024.109894 (Source: Neuropharmacology)
Source: Neuropharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Asmaa M Teema Sawsan A Zaitone Yasser M Moustafa Source Type: research
Retraction Notice to "Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis" [Neuropharmacology, 107 (2016) 432 - 450]
Neuropharmacology. 2024 Mar 4:109894. doi: 10.1016/j.neuropharm.2024.109894. Online ahead of print.NO ABSTRACTPMID:38443226 | DOI:10.1016/j.neuropharm.2024.109894 (Source: Neuropharmacology)
Source: Neuropharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Asmaa M Teema Sawsan A Zaitone Yasser M Moustafa Source Type: research
Retraction Notice to "Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis" [Neuropharmacology, 107 (2016) 432 - 450]
Neuropharmacology. 2024 Mar 4:109894. doi: 10.1016/j.neuropharm.2024.109894. Online ahead of print.NO ABSTRACTPMID:38443226 | DOI:10.1016/j.neuropharm.2024.109894 (Source: Neuropharmacology)
Source: Neuropharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Asmaa M Teema Sawsan A Zaitone Yasser M Moustafa Source Type: research
Retraction Notice to "Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis" [Neuropharmacology, 107 (2016) 432 - 450]
Neuropharmacology. 2024 Mar 4:109894. doi: 10.1016/j.neuropharm.2024.109894. Online ahead of print.NO ABSTRACTPMID:38443226 | DOI:10.1016/j.neuropharm.2024.109894 (Source: Neuropharmacology)
Source: Neuropharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Asmaa M Teema Sawsan A Zaitone Yasser M Moustafa Source Type: research
Retraction Notice to "Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis" [Neuropharmacology, 107 (2016) 432 - 450]
Neuropharmacology. 2024 May 1;248:109894. doi: 10.1016/j.neuropharm.2024.109894. Epub 2024 Mar 5.NO ABSTRACTPMID:38443226 | DOI:10.1016/j.neuropharm.2024.109894 (Source: Neuropharmacology)
Source: Neuropharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Asmaa M Teema Sawsan A Zaitone Yasser M Moustafa Source Type: research
Primary Ciliary Dyskinesia Caused by Homozygous DNAAF1 Mutations Resulting from a Consanguineous Marriage: A Case Report from Japan
We present the case of a 58-year-old female patient with primary ciliary dyskinesia (PCD). She was born to parents with a consanguineous marriage. Chest computed tomography conducted at age 41 years indicated no situs inversus, and findings of bronchiectasis were limited to the middle and lingular lobes. Despite long-term macrolide therapy, bronchiectasis exacerbations frequently occurred. PCD was suspected because of the low nasal nitric oxide level (20.7 nL/min). Electron microscopy revealed outer and inner dynein arm defects, and a genetic analysis identified a homozygous single-nucleotide deletion in the DNAAF1 gene. B...
Source: Internal Medicine - March 3, 2024 Category: Internal Medicine Authors: Masashi Ito Kozo Morimoto Mikio Saotome Akiko Miyabayashi Keiko Wakabayashi Hiroyuki Yamada Minako Hijikata Naoto Keicho Ken Ohta Source Type: research
AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia
CONCLUSIONS: In conclusion, our results suggest that long-term metformin treatment could promote ΔFosB degradation and thus attenuate the development of LID through activating the AMPK-mediated autophagy pathway. Overall, our results support the AMPK-mediated autophagy pathway as a novel therapeutic target for LID and also indicate that metformin is a promising therapeutic candidate for LID.PMID:38432574 | DOI:10.1016/j.cellsig.2024.111125 (Source: Cellular Signalling)
Source: Cellular Signalling - March 3, 2024 Category: Cytology Authors: Ke Liu Zhaoyuan Zhang Yu Xu Yi Wu Piaopiao Lian Zhuoran Ma Zhicheng Tang Xiaoqian Zhang Xiaoman Yang Heng Zhai Lei Zhang Yan Xu Xuebing Cao Source Type: research
Primary Ciliary Dyskinesia Caused by Homozygous DNAAF1 Mutations Resulting from a Consanguineous Marriage: A Case Report from Japan
We present the case of a 58-year-old female patient with primary ciliary dyskinesia (PCD). She was born to parents with a consanguineous marriage. Chest computed tomography conducted at age 41 years indicated no situs inversus, and findings of bronchiectasis were limited to the middle and lingular lobes. Despite long-term macrolide therapy, bronchiectasis exacerbations frequently occurred. PCD was suspected because of the low nasal nitric oxide level (20.7 nL/min). Electron microscopy revealed outer and inner dynein arm defects, and a genetic analysis identified a homozygous single-nucleotide deletion in the DNAAF1 gene. B...
Source: Internal Medicine - March 3, 2024 Category: Internal Medicine Authors: Masashi Ito Kozo Morimoto Mikio Saotome Akiko Miyabayashi Keiko Wakabayashi Hiroyuki Yamada Minako Hijikata Naoto Keicho Ken Ohta Source Type: research
AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia
CONCLUSIONS: In conclusion, our results suggest that long-term metformin treatment could promote ΔFosB degradation and thus attenuate the development of LID through activating the AMPK-mediated autophagy pathway. Overall, our results support the AMPK-mediated autophagy pathway as a novel therapeutic target for LID and also indicate that metformin is a promising therapeutic candidate for LID.PMID:38432574 | DOI:10.1016/j.cellsig.2024.111125 (Source: Cellular Signalling)
Source: Cellular Signalling - March 3, 2024 Category: Cytology Authors: Ke Liu Zhaoyuan Zhang Yu Xu Yi Wu Piaopiao Lian Zhuoran Ma Zhicheng Tang Xiaoqian Zhang Xiaoman Yang Heng Zhai Lei Zhang Yan Xu Xuebing Cao Source Type: research
