Sink or Swim? Clinical Objective Tests and Measures Associated with Shoulder Pain in Swimmers of Varied Age Levels of Competition: A Systematic Review
CONCLUSION: Swimmers of various ages may have different objective clinical tests and measures associated with the risk for developing shoulder pain. More studies are needed to fully understand risk factors for shoulder pain in the masters swim competition level, and to validate recommended cut points for various tests and measures.KEY LEVEL OF EVIDENCE: 3, Systematic review of mostly Level 3 studies.PMID:38179580 | PMC:PMC10761606 | DOI:10.26603/001c.90282 (Source: Physical Therapy)
Source: Physical Therapy - January 5, 2024 Category: Physiotherapy Authors: June Kennedy Thomas Otley Steph Hendren Heather Myers Angela Tate Source Type: research
Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa — a case report and literature review
Dyskinesia-hyperpyrexia syndrome, a rare medical emergency in Parkinson's disease, is first described in 2010. It is characterized by severe continuous dyskinesia associated with rhabdomyolysis, hyperthermia and subsequent alteration of the mental state. Gradual reduction of dopaminergic dose or DBS is recommended treatment. The prognosis is usually good, but sometimes fatal. But so far, this potentially fatal complication is not widely recognized by clinicians. In emergency, if clinicians fail to make prompt diagnosis and treatment, patients' conditions may get worse, and their lives may be threatened in serious cases. (S...
Source: Frontiers in Neurology - January 5, 2024 Category: Neurology Source Type: research
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines
Cell Res. 2024 Jan 2. doi: 10.1038/s41422-023-00906-z. Online ahead of print.ABSTRACTMonoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage and subsequent release in neurons. Impaired VMAT2 function underlies various neuropsychiatric diseases. VMAT2 inhibitors reserpine and tetrabenazine are used to treat hypertension, movement disorders associated with Huntington's Disease and Tardive Dyskinesia. Despite its physiological and pharmacological significance, the structural basis underlying VMAT2 substrate recognition and its inhibi...
Source: Cell Research - January 1, 2024 Category: Cytology Authors: Yuwei Wang Pei Zhang Yulin Chao Zhini Zhu Chuanhui Yang Zixuan Zhou Yaohui Li Yonghui Long Yuehua Liu Dianfan Li Sheng Wang Qianhui Qu Source Type: research
GSE250361 Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia I
Contributors : David Figge ; Karen E JaunarajsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusL-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). We found repeated L-DOPA exposure induces unique transcriptional behavior in striatal neurons that is associated with the development of dyskinetic behaviors. These results suggest the development of a long-term neuronal engram underlying the persistence of LID . (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE250362 Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia II
Contributors : David Figge ; Karen E JaunarajsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusL-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). We found repeated L-DOPA exposure induces unique transcriptional behavior in striatal neurons that is associated with the development of dyskinetic behaviors. These results suggest the development of a long-term neuronal engram underlying the persistence of LID . (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE250364 Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Disease Manifestations in Siblings with Primary Ciliary Dyskinesia
Annals of the American Thoracic Society,Volume 21, Issue 1, Page 173-175, January 2024. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - December 29, 2023 Category: Respiratory Medicine Authors: Dvir Gatt Michelle Shaw Jacob McCoy Fiona Kritzinger Melinda Solomon Sharon Dell Felix Ratjen Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings
CONCLUSION: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.PMID:38154480 | DOI:10.3349/ymj.2023.0238 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 28, 2023 Category: Universities & Medical Training Authors: Jiyoung Oh Jin-Sung Lee Moo Suk Park Young Ae Kang Hyung-Ju Cho Song Yee Kim Jinsei Jung Sun Och Yoon Kyung Won Kim Source Type: research
