Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Infection with Angiostrongylus cantonensis (AC) in humans or mice can lead to severe eosinophilic meningitis or encephalitis, resulting in various neurological impairments. Developing effective neuroprotective dr... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 23, 2024 Category: Microbiology Authors: Hui Huang, Zhongyuan Zhang, Mengdan Xing, Zihan Jin, Yue Hu, Minyu Zhou, Hang Wei, Yiwen Liang and Zhiyue Lv Tags: Research Source Type: research
Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease
In conclusion, co-treatment with ACEIs and L-dopa, such as perindopril, captopril, and enalapril, may mitigate the severity of L-DOPA-induced dyskinesia in a mouse model of PD.PMID:38642669 | DOI:10.1016/j.ejphar.2024.176573 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Hye-Yeon Park Ga Seul Lee Jun Go Young-Kyoung Ryu Chul-Ho Lee Jeong Hee Moon Kyoung-Shim Kim Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 18, 2024 Category: Respiratory Medicine Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Stepwise genetic approach for the diagnosis of primary ciliary dyskinesia in highly consanguineous populations
Conclusions
In highly consanguineous regions, a stepwise genetic testing approach is recommended. This approach may be particularly useful in areas where the ability to obtain confirmatory diagnostic tests through other modalities is less accessible. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Gatt, D., Golan Tripto, I., Levanon, E., Arwas, N., Hazan, G., Alkrinawi, S., Goldbart, A. D., Aviram, M. Tags: Original research Source Type: research
Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis
ConclusionThere are differences in age, gender, clinical characteristics, and CSF results in different subtypes of AE. First-line therapy failure would have poor functional recovery, and delayed therapy would increase the risk of relapse. Chloride ion content and white blood cell count in cerebrospinal fluid are positively correlated with the patient's exacerbation and admission to ICU. These indicators have certain clinical value for the prognosis of AE patients. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 18, 2024 Category: Neurology Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
