Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease
CONCLUSION: 4 weeks of aerobic exercise can effectively alleviate the development of L-DOPA-induced dyskinesia and improve motor function in PD mice. The related mechanism may be related to the inhibition of striatal Erk/MAPK signaling pathway overactivation by aerobic exercise, but this change did not occur selectively in D1-MSNs.PMID:38395109 | DOI:10.1016/j.brainresbull.2024.110906 (Source: Brain Research)
Source: Brain Research - February 23, 2024 Category: Neurology Authors: Fangyuan Zhou Longwei Wei Yinhao Wang Wei Chen Source Type: research
Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease
CONCLUSION: 4 weeks of aerobic exercise can effectively alleviate the development of L-DOPA-induced dyskinesia and improve motor function in PD mice. The related mechanism may be related to the inhibition of striatal Erk/MAPK signaling pathway overactivation by aerobic exercise, but this change did not occur selectively in D1-MSNs.PMID:38395109 | DOI:10.1016/j.brainresbull.2024.110906 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Fangyuan Zhou Longwei Wei Yinhao Wang Wei Chen Source Type: research
Caspase-8 dependent apoptosis contributes to dyskinesia caused by muscle defects and neurotoxicity in zebrafish exposed to zearalenone
Food Chem Toxicol. 2024 Feb 19:114516. doi: 10.1016/j.fct.2024.114516. Online ahead of print.ABSTRACTZearalenone (ZEA), one of the usual mycotoxins, has been recognized in many areas and crops, posing a significant threat to the living organisms even to human beings. However, the mechanisms of locomotive defects remain unknown. Herein, zebrafish larvae was employed to investigate ZEA effects on developmental indexes, muscle and neural toxicity, apoptosis, transcriptome and motor behaviors of zebrafish larvae. Zebrafish larvae exposed to ZEA (0, 0.5, 1, 2 and 4 μM) showed no change in survival rate, but the malformation ra...
Source: Food and Chemical Toxicology - February 21, 2024 Category: Food Science Authors: Yunpeng Wang Shuaiting Li Zhi Cheng Ziyuan Zhang Yu Xu Huan Zhang Ting Xu Jianqiang Chen Danyang Yin Wenhua Yan Huizhe Huang Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
Caspase-8 dependent apoptosis contributes to dyskinesia caused by muscle defects and neurotoxicity in zebrafish exposed to zearalenone
Food Chem Toxicol. 2024 Feb 19:114516. doi: 10.1016/j.fct.2024.114516. Online ahead of print.ABSTRACTZearalenone (ZEA), one of the usual mycotoxins, has been recognized in many areas and crops, posing a significant threat to the living organisms even to human beings. However, the mechanisms of locomotive defects remain unknown. Herein, zebrafish larvae was employed to investigate ZEA effects on developmental indexes, muscle and neural toxicity, apoptosis, transcriptome and motor behaviors of zebrafish larvae. Zebrafish larvae exposed to ZEA (0, 0.5, 1, 2 and 4 μM) showed no change in survival rate, but the malformation ra...
Source: Food and Chemical Toxicology - February 21, 2024 Category: Food Science Authors: Yunpeng Wang Shuaiting Li Zhi Cheng Ziyuan Zhang Yu Xu Huan Zhang Ting Xu Jianqiang Chen Danyang Yin Wenhua Yan Huizhe Huang Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
The value of re-evaluation and thorough family history taking for the diagnostic work-up of chorea
Tijdschr Psychiatr. 2024;66(1):51-54.ABSTRACTThe differential diagnosis of chorea encompasses a broad range of disorders. In psychiatry, tardive dyskinesia may be difficult to discern from other causes, particularly when the family history is negative. A 59-year-old man with an unclear medical history had been using risperidone for over a decade when we first saw him. He presented with severe dyskinesia in all extremities. The family history for neuropsychiatric disorders was negative. We interpreted the movement disorder as tardive dyskinesia, but later he turned out to suffer from Huntington’s disease. To impro...
Source: Tijdschrift voor Psychiatrie - February 21, 2024 Category: Psychiatry Authors: J J Luykx E van Duijn B Geerdinck E Burgers H P H Kremer R Veenhuizen Source Type: research
