Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease
ConclusionsData from an integrated analysis of studies in TD and an integrated analysis of studies of chorea in HD showed that deutetrabenazine has a favorable safety profile and is well tolerated across indications.Trial RegistrationClinicalTrials.gov identifiers, NCT02291861, NCT02195700, NCT01795859, NCT02198794, NCT01897896. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 1, 2024 Category: Neurology Source Type: research
4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms
Neuropharmacology. 2024 Mar 28:109926. doi: 10.1016/j.neuropharm.2024.109926. Online ahead of print.ABSTRACTWe tested the efficacy of 4'-fluorocannabidiol (4'-F-CBD), a semisynthetic cannabidiol derivative, and HU-910, a cannabinoid receptor 2 (CB2) agonist in resolving l-DOPA-induced dyskinesia (LID). Specifically, we were interested in studying whether these compounds could restrain striatal inflammatory responses and rescue glutamatergic disturbances characteristic of the dyskinetic state. C57BL/6 mice were rendered hemiparkinsonian by unilateral striatal lesioning with 6-OHDA. Abnormal involuntary movements were then i...
Source: Neuropharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Maur ício Dos Santos Pereira Gabriel Henrique Dias de Abreu Leonardo Cala ça Arruda Vanderlei Rita Raisman-Vozari Francisco Silveira Guimar ães Hui-Chen Lu Patrick Pierre Michel Elaine Del Bel Source Type: research
4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms
Neuropharmacology. 2024 Mar 28:109926. doi: 10.1016/j.neuropharm.2024.109926. Online ahead of print.ABSTRACTWe tested the efficacy of 4'-fluorocannabidiol (4'-F-CBD), a semisynthetic cannabidiol derivative, and HU-910, a cannabinoid receptor 2 (CB2) agonist in resolving l-DOPA-induced dyskinesia (LID). Specifically, we were interested in studying whether these compounds could restrain striatal inflammatory responses and rescue glutamatergic disturbances characteristic of the dyskinetic state. C57BL/6 mice were rendered hemiparkinsonian by unilateral striatal lesioning with 6-OHDA. Abnormal involuntary movements were then i...
Source: Neuropharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Maur ício Dos Santos Pereira Gabriel Henrique Dias de Abreu Leonardo Cala ça Arruda Vanderlei Rita Raisman-Vozari Francisco Silveira Guimar ães Hui-Chen Lu Patrick Pierre Michel Elaine Del Bel Source Type: research
4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms
Neuropharmacology. 2024 Mar 28;251:109926. doi: 10.1016/j.neuropharm.2024.109926. Online ahead of print.ABSTRACTWe tested the efficacy of 4'-fluorocannabidiol (4'-F-CBD), a semisynthetic cannabidiol derivative, and HU-910, a cannabinoid receptor 2 (CB2) agonist in resolving l-DOPA-induced dyskinesia (LID). Specifically, we were interested in studying whether these compounds could restrain striatal inflammatory responses and rescue glutamatergic disturbances characteristic of the dyskinetic state. C57BL/6 mice were rendered hemiparkinsonian by unilateral striatal lesioning with 6-OHDA. Abnormal involuntary movements were th...
Source: Neuropharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Maur ício Dos Santos Pereira Gabriel Henrique Dias de Abreu Leonardo Cala ça Arruda Vanderlei Rita Raisman-Vozari Francisco Silveira Guimar ães Hui-Chen Lu Patrick Pierre Michel Elaine Del Bel Source Type: research
Phosphoserine aminotransferase deficiency diagnosed by whole ‐exome sequencing and LC–MS/MS reanalysis: A case report and review of literature
ConclusionsOur findings demonstrate the importance of WES combined with LC –MS/MS reanalysis in the diagnosis of genetic diseases and expand thePSAT1 variant spectrum in PSATD. Moreover, we summarize all the cases caused byPSAT1 variants in the literature. This case provides a vital reference for the diagnosis of future cases. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - March 28, 2024 Category: Genetics & Stem Cells Authors: Jiaci Li,
Xinping Wei,
Yuchen Sun,
Xiaofang Chen,
Ying Zhang,
Xiaoyu Cui,
Jianbo Shu,
Dong Li,
Chunquan Cai Tags: CLINICAL REPORT Source Type: research
Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature
CONCLUSIONS: Our findings demonstrate the importance of WES combined with LC-MS/MS reanalysis in the diagnosis of genetic diseases and expand the PSAT1 variant spectrum in PSATD. Moreover, we summarize all the cases caused by PSAT1 variants in the literature. This case provides a vital reference for the diagnosis of future cases.PMID:38546032 | DOI:10.1002/mgg3.2400 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Jiaci Li Xinping Wei Yuchen Sun Xiaofang Chen Ying Zhang Xiaoyu Cui Jianbo Shu Dong Li Chunquan Cai Source Type: research
Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature
CONCLUSIONS: Our findings demonstrate the importance of WES combined with LC-MS/MS reanalysis in the diagnosis of genetic diseases and expand the PSAT1 variant spectrum in PSATD. Moreover, we summarize all the cases caused by PSAT1 variants in the literature. This case provides a vital reference for the diagnosis of future cases.PMID:38546032 | DOI:10.1002/mgg3.2400 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Jiaci Li Xinping Wei Yuchen Sun Xiaofang Chen Ying Zhang Xiaoyu Cui Jianbo Shu Dong Li Chunquan Cai Source Type: research
Respiratory Aspects of Primary Ciliary Dyskinesia
This review article explores the respiratory aspects of primary ciliary dyskinesia (PCD), a rare, heterogenous, genetic disorder characterized by impaired motile ciliary function. It discusses the clinical diagnosis and management strategies for PCD-related respiratory disease, including chronic sinusitis, otitis media with effusion, recurrent pneumonia, and bronchiectasis. The review emphasizes the need for a multidisciplinary approach to optimize care and clinical trials to improve outcomes in individuals with PCD, highlighting the importance of accurate diagnosis. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - March 28, 2024 Category: Respiratory Medicine Authors: Wilfredo De Jes ús-Rojas, Adam J. Shapiro, Amelia Shoemark Source Type: research
Efficacy of acupuncture (Jins three-needle) on motor symptoms and anxiety in patients with Parkinsons disease: protocol for a multicentre, randomised, assessor-blinded clinical trial
Introduction
Parkinson’s disease (PD) has a significant impact on a substantial number of individuals in China. Notably, 31% of patients with PD also grapple with the additional burden of anxiety. This dual challenge of managing both PD and anxiety underscores the complexity of the condition and the diverse range of symptoms patients may experience. Considering the circumstances, the cost and potential drawbacks associated with traditional antiparkinsonian drugs become increasingly relevant. Acupuncture emerges as a significant non-pharmacological adjunct therapy. Offering a potentially safer and more cost-effective ...
Source: BMJ Open - March 28, 2024 Category: General Medicine Authors: Liu, X., Fan, J., Leong, I. I., Lu, W., Zhang, Y., Gong, M., Zhuang, L. Tags: Open access, Neurology Source Type: research
