Management of bleeding peptic duodenal ulcer refractory to endoscopic treatment: surgery or transcatheter arterial embolization as first-line therapy? A retrospective single-center study and systematic review
The objective of this study was to compare the results of transcatheter arterial embolization(TAE) with surgery in terms of efficacy in the context of bleeding duodenal ulcer (BDU) refractory to endoscopic treatment.Materials and methodsFrom January 2006 to December 2016, all patients treated for a BDU refractory to endoscopic treatment were included in this observational, comparative, retrospective, single-center study. Primary endpoint was the overall success of treatment of BDU requiring surgical and/or TAE. The secondary endpoints were pre-interventional data, recurrence rates, feasibility of secondary treatment, morbi...
Source: European Journal of Trauma and Emergency Surgery - April 3, 2020 Category: Emergency Medicine Source Type: research

A Case of Unexplained Duodenal Ulcer and Massive Gastrointestinal Bleed
Publication date: Available online 29 March 2020Source: Clinica Chimica ActaAuthor(s): Yiqi Ruben Luo, Robert Goodnough, Rebecca Menza, Adina Badea, Hubert Yiu-Wei Luu, Lucy Z. Kornblith, Kara L. Lynch (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 31, 2020 Category: Laboratory Medicine Source Type: research

A Case of Unexplained Duodenal Ulcer and Massive Gastrointestinal Bleed.
Abstract A 73-year-old man was displaying symptoms of massive gastrointestinal (GI) bleed. Surgical actions were performed to control the bleed caused by an erosive duodenal ulcer with duodenal perforation. When investigating the culprit of this case, the pain medications prescribed two weeks prior by a traditional Chinese medicine doctor raised attention. The patient's admission serum sample and the pain medications from unknown sources were analyzed using a clinically validated liquid chromatography-high-resolution mass spectrometry (LC-HRMS) method. The NSAIDs diclofenac, piroxicam, and indomethacin were identi...
Source: International Journal of Clinical Chemistry - March 29, 2020 Category: Chemistry Authors: Ruben Luo Y, Goodnough R, Menza R, Badea A, Yiu-Wei Luu H, Kornblith LZ, Lynch KL Tags: Clin Chim Acta Source Type: research

Prevalence of Helicobacter pylori babA , oipA , sabA , and homB genes in isolates from Chinese patients with different gastroduodenal diseases
This study aimed to investigate the correlation between the four OMP genes (babA,oipA,sabA, andhomB) and gastroduodenal diseases. One hundred and seventy-sevenH. pylori strains were isolated from Chinese patients with different gastroduodenal diseases (49 chronic gastritis, 19 gastric ulcer, 33 gastric cancer, and 76 duodenal ulcer), 94 of which contained pathological information (41 superficial gastritis, 24 intestinal hyperplasia, and 29 gastric adenocarcinoma). The full-length amplification ofbabA,oipA,sabA,and homB genes was acquired and sequenced. Then, the genetic polymorphism was analyzed to compare with the referen...
Source: Medical Microbiology and Immunology - March 26, 2020 Category: Microbiology Source Type: research

Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population.
eybek B Abstract Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical association of the cagL gene with host HLA alleles in H. pylori strains that were isolated from patients with gastric cancer, DU, and non-ulcer dyspepsia (NUD) and to determine the HLA al...
Source: Infection, Genetics and Evolution - March 13, 2020 Category: Genetics & Stem Cells Authors: Kocak BT, Saribas S, Demiryas S, Yilmaz E, Uysal O, Kepil N, Demirci M, Dınc HO, Akkus S, Gülergün R, Gareayaghi N, Dağdeviren HE, Ozbey D, Dağ HH, Tokman HB, Tasci I, Kocazeybek B Tags: Infect Genet Evol Source Type: research

Duodenal ulcer promoting gene (DupA), plasticity region genes and sigma factors in H. pyloristrains from Nigeria
Conclusion: These results suggest that the presence ofjhp0917, jhp0914/917 and G27 variant could be used as marker to predict the pathological effect of severity in Nigeria patients withH. pylori infection. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - February 29, 2020 Category: Infectious Diseases Source Type: research

The use of emergency laparoscopy for acute abdomen in the elderly: the FRAILESEL Italian Multicenter Prospective Cohort Study
AbstractAs the world population is aging rapidly, emergency abdominal surgery for acute abdomen in the elderly represents a global issue, both in developed and developing countries. Data regarding all the elderly patients who underwent emergency abdominal surgery from January 2017 to December 2017 at 36 Italian surgical departments were analyzed with the aim to appraise the contemporary reality regarding the use of emergency laparoscopy for acute abdomen in the elderly. 1993 patients were enrolled. 1369 (68.7%) patients were operated with an open technique; whereas, 624 (31.3%) underwent a laparoscopic operation. The posto...
Source: Updates in Surgery - February 22, 2020 Category: Surgery Source Type: research

Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway.
Conclusions: Our data demonstrate that LZD protects the duodenal mucosa from IND-caused lesions, which is at least partially attributable to the interaction of its potential cytoprotective and anti-inflammatory mechanisms together with enhancement of the mucosal immunity through TLR-2/MyD88 signaling pathway. PMID: 32063985 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 19, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Rare malignant ulcer related to primary intestinal diffuse large B-cell lymphoma: A case report
We present a case of a 57-year-old male diagnosed in the Gastroenterology Department, which presented a bleeding duodenal ulcer with irregular borders. Diagnoses: The immunohistochemical staining showed: CD20(+++), CD10(+) and Ki-67>40%. Interventions: The patient was successfully treated by Poly-chemotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vindesine and prednisolone). Outcomes: After 6 courses of chemotherapy treatment, the duodenal ulcer was completely healed by reviewing the UGIE. Lessons: Our report might give further strength to avoiding the erroneous and missed diagnosis for PI-D...
Source: Medicine - February 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Bezoar in upper gastrointestinal endoscopy: A single center experience.
CONCLUSION: The findings of this study indicated that bezoars are more common among subjects with history of gastrointestinal surgery, diabetes mellitus, or psychiatric disorders; bezoars are closely related to peptic ulcer and reflux esophagitis; and they can be successfully treated with endoscopy. PMID: 32141815 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Gökbulut V, Kaplan M, Kaçar S, Akdoğan Kayhan M, Coşkun O, Kayaçetin E Tags: Turk J Gastroenterol Source Type: research

Endoloop rescue therapy for a duodenal ulcer that re-bled under the clip base after application of an 11/3 traumatic over-the-scope clip
Endoscopy DOI: 10.1055/a-1089-7580 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - January 29, 2020 Category: Gastroenterology Authors: Jung, Carlo Sportes, Adrien Ellenrieder, Volker Wedi, Edris Tags: E-Videos Source Type: research

Successful closure of chronic recurrent Enterocutaneous fistula with a concurrent over ‐the‐scope closure and a stent placement
We report a case of perforated duodenal ulcer that failed surgical intervention and, however, was successfully closed with over‐the‐scope clip ( OTSC) closure with concomitant placement of fully covered stent. AbstractGastrointestinal ulcers and perforations can occur as a complication of nonsteroidal anti ‐inflammatory drugs (NSAID). Emerging endoscopic technologies can be utilized to successfully intervene perforations that fail surgical intervention. We report a case of perforated duodenal ulcer that failed surgical intervention and, however, was successfully closed with over‐the‐scope clip ( OTSC) closure wit...
Source: Clinical Case Reports - January 20, 2020 Category: General Medicine Authors: Abdulfatah Issak, Mustafa Musleh Tags: CASE REPORT Source Type: research

Single-Port Laparoscopic Repair of Perforated Duodenal Ulcers
ConclusionLaparoscopic single-port repair using conventional straight laparoscopic instruments with intra-corporeal knot tying technique was safe and feasible for patients with perforated duodenal ulcers with low risk factors. This method offers results comparable to those expected with the standard multiport laparoscopic approach with the addition of improved cosmetic outcomes. (Source: World Journal of Surgery)
Source: World Journal of Surgery - January 2, 2020 Category: Surgery Source Type: research

Endoscopic visualization of an intervention-treated pseudoaneurysm at a duodenal ulcer.
PMID: 31875665 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 28, 2019 Category: Internal Medicine Authors: You MW, Oh CH, Kwon SW, Dong SH Tags: Korean J Intern Med Source Type: research

A survey of primary-care pediatricians regarding the management of Helicobacter pylori infection and celiac disease
ConclusionsAdherence to the guidelines on management ofH. pylori infection was low, while adherence to the guidelines on celiac disease management was high among primary-care pediatricians. Educational interventions are needed to improveH. pylori infection management among primary-care pediatricians. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - December 27, 2019 Category: International Medicine & Public Health Source Type: research

Medicinal plants in the treatment of peptic ulcer disease: A review.
Abstract Peptic ulcer disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to evaluate the potential role of nat...
Source: Mini Reviews in Medicinal Chemistry - December 27, 2019 Category: Chemistry Authors: Ardalani H, Hadipanah A, Sahebkar A Tags: Mini Rev Med Chem Source Type: research

Impact of PSCA polymorphisms on the risk of duodenal ulcer.
CONCLUSIONS: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population. PMID: 31839644 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - December 17, 2019 Category: Epidemiology Tags: J Epidemiol Source Type: research

Variable expressivity and novel pten gene mutations in cowden syndrome
We reported an isolated case and 1 family with several individuals affected by CS. The isolated case showed typical features including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity and was caused by a novel nonsense mutation (c.940 G>T) in the PTEN gene. In the family, the proband showed erythema nodosum, duodenal ulcer, intestinal polyps, cervical lipoma, renal cysts, and glaucoma, whereas her family revealed multiple members with intestinal polyps and a sister with breast cancer diagnosed at early age. (Source: Oral Surgery, Oral Medicine, Oral Patho...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: RENATO ASSIS MACHADO, L ÍVIA MARIS RIBEIRO PARANAÍBA, BRENO AMARAL ROCHA, GERALDO DE OLIVEIRA SILVA, THAYS TEIXEIRA DE SOUZA, FÁBIO RAMOA PIRES, RICARDO DELLA COLETTA Source Type: research

Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.
CONCLUSIONS: The effect of PAP therapy on all-cause mortality was uncertain. In addition, although we found evidence that PAP therapy did not reduce the risk of cardiac-related mortality and rehospitalisation, there was some indication of an improvement in quality of life for heart failure patients with CSA. Furthermore, the evidence was insufficient to determine whether adverse events were more common with PAP than with usual care. These findings were limited by low- or very low-quality evidence. PAP therapy may be worth considering for individuals with heart failure to improve quality of life. PMID: 31797360 [PubMed...
Source: Cochrane Database of Systematic Reviews - December 4, 2019 Category: General Medicine Authors: Yamamoto S, Yamaga T, Nishie K, Nagata C, Mori R Tags: Cochrane Database Syst Rev Source Type: research

Lactate Level Predicts Mortality in Patients with Upper Gastrointestinal Bleeding.
Conclusions: The venous blood lactate value of a patient who was admitted to the emergency department with UGI bleeding might be helpful in predicting the transfusion needs of the patient and predicting the mortality. PMID: 31781189 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Severe bleeding from a duodenal ulcer after orthognathic surgery: a case report
Chronic non-steroidal anti-inflammatory drug use is strongly associated with peptic ulcer disease, and corticosteroid use has also been cited as a risk factor. Both are frequently prescribed for short courses after orthognathic surgery to minimize edema. It appears that no cases of severe bleeding from a duodenal ulcer have been reported during the postoperative period after orthognathic surgery. This case describes a patient who experienced this severe bleeding despite having no risk factors. (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - November 21, 2019 Category: ENT & OMF Authors: Matthew Pham, Natalie Dunlop, Linda Pham, Timothy Turvey Tags: Case Report Source Type: research

Helicobacter pylori And Duodenal Ulcer: Systematic Review Of Controversies In Causation
(Source: Clinical and Experimental Gastroenterology)
Source: Clinical and Experimental Gastroenterology - November 18, 2019 Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research

Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival.
Conclusions: Our results suggest that KFX has protective effects on WIRS-induced gastric ulcer via inflammatory reactions, oxidative stress inhibition, and pro-survival action, which were the results of activating the IGF-1/PTEN/Akt signalling pathway. Our results provide evidence of KFX for treating gastric ulcer. PMID: 31696757 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 9, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The safety and effectiveness of vonoprazan-based Helicobacter pylori eradication therapy; a prospective post-marketing surveillance.
Conclusion: No new safety concerns were observed, and the effectiveness of vonoprazan-based triple therapy was confirmed in routine clinical practice. Trial registration: This study is registered at the Japan Pharmaceutical Information Center Clinical Trials Information (JapicCTI-153003). PMID: 31646920 [PubMed - as supplied by publisher] (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - October 27, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Pathogenesis and clinical management of Helicobacter pylori gastric infection.
Abstract Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. However, its prevalence varies among different geographic areas, and is influenced by several factors. The infection can be acquired by means of oral-oral or fecal-oral transmission, and the pathogen possesses various mechanisms that improve its capacity of mobility, adherence and manipulation of the gastric microenvironment, making possible the colonization of an organ with a highly acidic lumen. In addition, H. pylori presents a large variety of virulence factors that improve its pa...
Source: World Journal of Gastroenterology : WJG - October 7, 2019 Category: Gastroenterology Authors: de Brito BB, da Silva FAF, Soares AS, Pereira VA, Santos MLC, Sampaio MM, Neves PHM, de Melo FF Tags: World J Gastroenterol Source Type: research

Successful biliary self ‐expandable metallic stenting using an ultra‐slim endoscope for cholangitis caused by pancreatic cancer
AbstractAn 80 ‐year‐old man who had a 10×50‐mm self‐expandable metallic stent (SEMS) (BONA‐SHIMSTENT biliary‐covered; Standard SciTech Inc, Seoul, South Korea) placed for biliary obstruction due to pancreatic cancer presented with fever and jaundice. He previously underwent distal gastrectomy with Bi llroth II reconstruction for duodenal ulcer. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - October 4, 2019 Category: Gastroenterology Authors: Akihiko Kida, Koichiro Matsuda, Masaaki Yano, Fumitaka Arihara, Kohei Ogawa, Mitsuru Matsuda, Akito Sakai Tags: How I Do It Source Type: research

Clinical Outcome of the Visible Coil During Endoscopy After Transcatheter Arterial Embolization for Gastrointestinal Bleeding
ConclusionsExtravascular coil after TAE for gastrointestinal bleeding is rare, and the most common underlying cause is duodenal ulcer bleeding. The extravascular coils eventually show a healing process with adequate treatment of underlying bowel pathologies. (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - October 2, 2019 Category: Radiology Source Type: research

A226 Giant Perforated Duodenal Ulcer after Vertical Banded Gastroplasty
We present a case of a 45 year old gentleman with a remote history of vertical banded gastroplasty and abdominal pain. Workup ultimately revealed a chronic complex large ulcer with erosion of the vertical banded gastroplasty. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Amy Yetasook, Aaron Sabbota, Pearl Ma, Amarita Klar, Keith Boone, Kelvin Higa Source Type: research

Clinical Profile, Severity and Outcome of Acute Upper Gastrointestinal Bleeding in Elderly Patients Compared to Non-elderly Patients: A Prospective Observational Study.
Authors: Sourabh S, Sharma N, Sharma R, Kumar R, Thakur S, Bodh V, Sharma B Abstract Aim: To determine the clinical profile, severity and outcome of acute upper gastrointestinal bleeding (UGIB) in elderly subjects (>60 years) compared to the non elderly ones (
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer —A Study of the GANNET53 Consortium
Conclusions: The combination of ganetespib 150 mg/m2 with paclitaxel 80 mg/m2 once weekly for 3 out of 4 weeks was generally well-tolerated with no DLTs, and therefore chosen for the randomized phase II trial. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 10, 2019 Category: Cancer & Oncology Source Type: research

Ilaprazole Compared With Rabeprazole in the Treatment of Duodenal Ulcer: A Randomized, Double-blind, Active-controlled, Multicenter Study
Conclusions: Ilaprazole 5 mg is not inferior to rabeprazole 10 mg in treating DU, and a dose-effect relationship have been revealed between 5 mg and 10 mg of ilaprazole. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Prevalence of and Helicobacter pylori infection rate in heterotopic gastric mucosa on histological analysis of duodenal specimens from patients with duodenal ulcer.
This study was designed to assess the prevalence and associations of heterotopic gastric mucosa in duodenal ulcers. The present study included 137 patients who underwent biopsy or resection of duodenal ulcer. We detected gastric foveolar metaplasia due to inflammation from a heterotopic gastric mucosa using immunohistochemical staining. Heterotopic gastric mucosa consists of foveolar epithelium (MUC5AC-positive) and fundic gland (H⁺K⁺ ATPase-positive parietal cells, pepsinogen I-positive chief cells and MUC6-positive mucous neck cells), whereas gastric metaplasia is composed of foveolar epithelium without fundic glands...
Source: Histology and Histopathology - July 4, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research

Endoscopic stent treatment of a duodenal ulcer perforation using a semi ‐covered stent
Placement of a covered self ‐expandable metal stent when primary surgery had failed to close the duodenal ulcer perforation or as a primary modality is a promising procedure when compared to other currently available types of surgical rescue or intervention. AbstractPlacement of a covered self ‐expandable metal stent when primary surgery had failed to close the duodenal ulcer perforation or as a primary modality is a promising procedure when compared to other currently available types of surgical rescue or intervention. (Source: Clinical Case Reports)
Source: Clinical Case Reports - July 4, 2019 Category: General Medicine Authors: Thor Erik Holm, Snorri Olafsson, Airazat M. Kazaryan Tags: CASE REPORT Source Type: research

Efficacy and safety of eradication therapy for elderly patients with helicobacter pylori infection
This study investigated the efficacy and safety of H. pylori eradication therapy for elderly patients. Retrospective investigation of 1271 cases (median age: 61 years, 730 male) of H. pylori infection was performed to compare clinical indications and outcomes among the younger group (75 years old). Chronic gastritis (77.0%) and gastric and/or duodenal ulcer (16.4%) were the most frequent indications for eradication therapy in the cohort. The respective eradication and AE rates for the first and second treatment regimens were 92.1% (1044 of 1133 cases) and 9.1% (103 of 1133 cases) and 84.2% (123 of 146 cases) and 8.9% (13...
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Changing patterns of upper gastrointestinal bleeding over 23 years in Turkey.
CONCLUSION: Over the 23 years studied, the causes of NVUGB changed, probably because the population was increasingly elderly population and because of the use of anticoagulants and better therapeutic approaches to chronic duodenal ulcers. The use of emergency surgical hemostasis reduced, but mortality rate did not significantly change between the two specific periods. PMID: 31258140 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - July 1, 2019 Category: Gastroenterology Authors: Danış N, Tekin F, Akarca US, Ünal NG, Erdoğan EI, Akat K, Demirkoparan Ü, Karasu Z, Turan İ, Oruç N, Aydın A, Ersöz G, Vardar R, Özütemiz Ö, Günşar F Tags: Turk J Gastroenterol Source Type: research

Laparoscopy in Acute Care Surgery: Repair of Perforated Duodenal Ulcer
Conclusions: Laparoscopy in the treatment of perforated duodenal ulcer is safe and can be utilized as a routine approach for the treatment of this pathology.Med Princ Pract (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - June 12, 2019 Category: Internal Medicine Source Type: research

Tu1947 STENT TREATMENT OR SURGICAL CLOSURE FOR PERFORATED DUODENAL ULCERS – A PROSPECTIVE RANDOMIZED STUDY IN PATIENTS
Standard treatment for perforated duodenal ulcer is open or laparoscopic surgery. Treatment with nasogastric tube and suction is sometimes used in patients with high co-morbidity but has shown poor results. We have previously used stent treatment in patients with high co-morbidity with good results. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - June 1, 2019 Category: Gastroenterology Authors: Jorge Arroyo V ázquez, Maria Bergström, Per-Ola Park Tags: Tuesday abstract Source Type: research

Endoscopic and Histological Findings among Israeli Populations Infected with Helicobacter pylori: Does Ethnicity Matter?
Authors: Mahamid M, Mari A, Khoury T, Bragazzi NL, Ghantous M, Abu-Elhija O, Watad A Abstract BACKGROUND: The prevalence of Helicobacter pylori varies geographically by age, race, and socioeconomic status (SES). However, the impact of ethnicity on endoscopic outcomes in infected individuals is not well known. OBJECTIVES: To assess the impact of ethnicity among Israelis with biopsy-proven H. pylori infection. METHODS: A retrospective study, including patients who underwent gastroscopy and were diagnosed histologically with H. pylori infection, was conducted. Information on demographics, SES, medications, and...
Source: The Israel Medical Association Journal - May 31, 2019 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Helicobacter pylori genotypes among Belarus patients with gastroduodenal disorders and their association with clinical outcome.
Abstract The aim of this study was to evaluate the prevalence of Helicobacter pylori genotypes (vacA and cagPAI) directly in gastric biopsy specimens in patients with gastric diseases in Belarus. Gastric biopsies were collected from 461 patients with different gastrointestinal disorders: superficial gastritis (287 subjects), atrophy gastritis (59 subjects), erosive gastritis (47 subjects), duodenal ulcer disease (54 subjects), and stomach ulcer (14 subjects). PCR-based genotyping was used to detect s1a, s1b, s2, m1a, m1b, m2, cagM, cagA, and cagT genes. Overall prevalence of vacA s1a allele was 60.5% followed by m...
Source: Acta Microbiologica et Immunologica Hungarica - May 17, 2019 Category: Microbiology Authors: Yanovich O, Doroshko M, Titov L Tags: Acta Microbiol Immunol Hung Source Type: research

Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer
Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokin... (Source: BMC Research Notes)
Source: BMC Research Notes - May 15, 2019 Category: Research Authors: Ljiljana Milic, Aleksandar Karamarkovic, Dusan Popadic, Ana Sijacki, Ilijana Grigorov, Emina Milosevic, Vladica Cuk and Predrag Pesko Tags: Research note Source Type: research

Assessment of PULP score in predicting 30-day perforated duodenal ulcer morbidity, and comparison of its performance with Boey and ASA, a retrospective study
ConclusionPULP score had the largest AUC and was the only score to significantly predict post PDU repair 30-day morbidity. (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - May 11, 2019 Category: General Medicine Source Type: research

Over-the-scope clip used to treat duodenal ulcer can cause damage to ulcer base and massive bleeding
Endoscopy DOI: 10.1055/a-0885-9786 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - May 2, 2019 Category: Gastroenterology Authors: Daire, Emilien Forte, Emmanuel Mennassel, Badis Ber, Charles-Eric Roy, Emilie Jacques, J érémie Pioche, Mathieu Tags: E-Videos Source Type: research

Gastrointestinal basidiobolomycosis in a patient suffering from duodenal ulcer with perforation: First case report from Italy.
We report here the first case of GIB diagnosed in Italy in a patient suffering from a duodenal ulcer with perforation. The patient was successfully treated with itraconazole. The absence of non-specific signs and symptoms of GIB may delay a definitive diagnosis and treatment. A microbiological investigation should always be requested in order to reach a rapid and definitive diagnosis and to rule out other intestinal diseases. PMID: 30994179 [PubMed - as supplied by publisher] (Source: New Microbiologica)
Source: New Microbiologica - April 19, 2019 Category: Microbiology Tags: New Microbiol Source Type: research

Helicobacter pylori and hematological disorders.
Authors: Santambrogio E, Orsucci L Abstract Helicobacter pylori (H. pylori) is one of the most common worldwide infection, which can affect adults as children. The prevalence of this bacterium is variable in different countries, depending on various hygienic and socioeconomic conditions and living customs. The major damaged tissues of the infection are in the upper gastrointestinal tract, causing gastritis, gastric and duodenal ulcer and gastrointestinal malignancy. Nevertheless, other disorders are associated with this pathogen, including several hematological diseases, such as iron deficiency anemia, immune throm...
Source: Minerva Gastroenterologica e Dietologica - April 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers.
Authors: Spiropoulou A, Zareifopoulos N, Bellou A, Spiropoulos K, Tsalikis L Abstract Both periodontitis and chronic obstructive pulmonary disease (COPD) are among the most common diseases associated with smoking. These conditions frequently present alongside comorbidities including diabetes, coronary heart disease, duodenal ulcer, deep vein thrombosis, pulmonary embolism, osteoporosis and muscle atrophy. Chronic inflammation contributes to the pathology of both periodontitis and COPD, and in patients suffering from both conditions treatment of periodontitis may lead to relief from COPD symptoms as well. Smoking co...
Source: Monaldi Archives for Chest Disease - April 12, 2019 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Carrying a 112  bp-segment in Helicobacter pylori dupA may associate with increased risk of duodenal ulcer.
Carrying a 112 bp-segment in Helicobacter pylori dupA may associate with increased risk of duodenal ulcer. Infect Genet Evol. 2019 Apr 11;: Authors: Fatahi G, Abadi ATB, Peerayeh SN, Forootan M Abstract The discovery of Helicobacter pylori in 1983 challenged researchers around the world to identify this pathogen's major virulence factors. The main rationale for this kind of research was to identify a biomarker associated with specific diseases following H. pylori colonization. Among different investigated virulence factors, duodenal ulcer promoting gene A (dupA) has been found to be associated with ...
Source: Infection, Genetics and Evolution - April 11, 2019 Category: Genetics & Stem Cells Authors: Fatahi G, Abadi ATB, Peerayeh SN, Forootan M Tags: Infect Genet Evol Source Type: research

[Stereotactic body radiation therapy for hepatocellular carcinoma: Results from a retrospective multicentre study].
CONCLUSION: Stereotactic body radiation therapy is effective and well-tolerated for inoperable hepatocellular carcinoma or as a bridge to liver transplantation. Toxicity is mainly related to cirrhotic background and requires a selection of patients and strict dose constraints. PMID: 30952560 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 2, 2019 Category: Cancer & Oncology Authors: Scher N, Janoray G, Riet FG, Le Bayon AG, Debbi K, Lévy S, Louisot P, Garaud P, Chajon E, Barillot I, Salamé É, de Crevoisier R, Chapet S, Calais G Tags: Cancer Radiother Source Type: research

Bilio-digestive secondary to duodenal ulcer.
PMID: 30926208 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Meriam S, Dorra T, Asma O, Hela E, Dalila G Tags: Presse Med Source Type: research

Ten-year experience of smoking cessation in a single center in Japan
ConclusionsBaseline exhaled CO level and mental disorders were significantly associated with either success or failure of smoking cessation. (Source: Respiratory Investigation)
Source: Respiratory Investigation - February 20, 2019 Category: Respiratory Medicine Source Type: research