Keverprazan Hydrochloride: First Approval
AbstractKeverprazan hydrochloride ( 凯普拉生) is a potassium ion competitive acid blocker that is being developed by Jiangsu Carephar Pharmaceuticals for the treatment of acid-related disease. Keverprazan hydrochloride was recently approved in China for the treatment of adults with reflux oesophagitis or duodenal ulcer. This artic le summarizes the milestones in the development of keverprazan hydrochloride leading to this first approval for reflux oesophagitis and duodenal ulcer. (Source: Drugs)
Source: Drugs - April 19, 2023 Category: Drugs & Pharmacology Source Type: research
Experience in diagnosis and treatment of duodenal ulcer perforation in children
This study aims to summarize our experience in diagnosis and treatment of pediatric duodenal ulcer perforation in a National Center for Children ’s Health. (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 30, 2023 Category: Pediatrics Authors: Qiulong Shen, Tingting Liu, Siwei Wang, Li Wang and Dayong Wang Tags: Research Source Type: research
Laparoscopic Graham Patch for Anterior Duodenal Perforation in a 6-Year-Old
We present a case of a perforated peptic ulcer in a 6-year-old with abdominal pain and emesis with CT findings of moderate pneumoperitoneum and pelvic free fluid without a distinct cause. He was emergently transferred, found to be peritonitic, and taken to the operating room for diagnostic laparoscopy revealing an anterior duodenal ulcer, and underwent laparoscopic Graham patch repair. Postoperatively, the child had positive fecal antigen for H. pylori. He was treated with triple therapy and underwent subsequent testing to confirm eradication. Perforated peptic ulcer is an uncommon pediatric surgical problem, and imaging m...
Source: The American Surgeon - March 27, 2023 Category: Surgery Authors: Michelle R McCullers Caroline C Shin Christopher M Anderson Source Type: research
Laparoscopic Graham Patch for Anterior Duodenal Perforation in a 6-Year-Old
We present a case of a perforated peptic ulcer in a 6-year-old with abdominal pain and emesis with CT findings of moderate pneumoperitoneum and pelvic free fluid without a distinct cause. He was emergently transferred, found to be peritonitic, and taken to the operating room for diagnostic laparoscopy revealing an anterior duodenal ulcer, and underwent laparoscopic Graham patch repair. Postoperatively, the child had positive fecal antigen for H. pylori. He was treated with triple therapy and underwent subsequent testing to confirm eradication. Perforated peptic ulcer is an uncommon pediatric surgical problem, and imaging m...
Source: The American Surgeon - March 27, 2023 Category: Surgery Authors: Michelle R McCullers Caroline C Shin Christopher M Anderson Source Type: research
dupA+H. pylori reduces diversity of gastric microbiome and increases risk of erosive gastritis
Helicobacter pylori is believed to induce gastropathy; however, the exact pathogenic molecules involved in this process have not been elucidated. Duodenal ulcer promoting gene A (DupA) is a virulence factor with a controversial role in gastric inflammation and carcinogenesis. To explore and confirm the function of DupA in gastropathy from the perspective of the microbiome, we investigated the microbial characteristics of 48 gastritis patients through 16S rRNA amplicon sequencing. In addition, we isolated 21 H. pylori strains from these patients and confirmed the expression of dupA using PCR and qRT-PCR. Bioinformatics anal...
Source: Frontiers in cellular and infection microbiology - March 17, 2023 Category: Microbiology Source Type: research
The Distribution and Phenotypes of Blood Groups in Hematologic Malignancies
CONCLUSION: We determined a significant relationship between hematologic malignancies and blood group systems. In our study, due to the low number of cases and few hematological malignancy types, extensive studies with more cases and more hematologic cancer types are needed.PMID:36861861 | DOI:10.5152/eurasianjmed.2023.21124 (Source: Cancer Control)
Source: Cancer Control - March 2, 2023 Category: Cancer & Oncology Authors: Mete Erdemir Fuat Erdem G ülden Sincan Source Type: research
Case Report: Erector Spinae Block in Perforated Viscus
CONCLUSION: ESPB can provide opioid free analgesia for laparoscopic repair of perforated duodenal ulcer both intra and postoperatively.PMID:36814519 | PMC:PMC9940489 | DOI:10.2147/LRA.S393913 (Source: Local and Regional Anesthesia)
Source: Local and Regional Anesthesia - February 23, 2023 Category: Anesthesiology Authors: Jassim Rauf Mohammad Mohsin A M Haji Source Type: research
