Breast Cancer Subtypes: Clinicopathologic Features and Treatment Considerations
AbstractPurpose of reviewThe purpose of this review is to provide an overview of ten unique breast cancer subtypes and their clinicopathologic features and treatment implications.Recent findingsRecent findings show that while many subtypes (mucinous, papillary, tubular, apocrine) have favorable biology, with better overall survival than invasive ductal carcinoma, some (metaplastic, adenoid cystic) are more aggressive portending worse prognosis for patients.SummaryThe differences in histology represented in these breast cancer subtypes often impacts biology, behavior, and prognosis. Due to their rarity, additional research ...
Source: Current Breast Cancer Reports - March 26, 2024 Category: Cancer & Oncology Source Type: research
Delayed Diagnosis of Inflammatory Breast Cancer Presenting as Acute Mastitis in a Patient One Month Postpartum
Am Surg. 2024 Mar 24:31348241241736. doi: 10.1177/00031348241241736. Online ahead of print.ABSTRACTInflammatory breast cancer (IBC) is a rare yet aggressive form of invasive ductal carcinoma, with a poor prognosis and decreased 5-year survival rates. Characteristic findings for IBC include rapid onset of breast edema, peau d'orange appearance, and involvement of the breast skin. Additionally, diagnosis is confirmed with a skin punch biopsy. With such nonspecific features, IBC can be mistaken for benign etiologies, causing delays in diagnosis and treatment. This patient is a 44-year-old woman presenting with left breast swe...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: Ananya Seth Eliza M Slama Source Type: research
Delayed Diagnosis of Inflammatory Breast Cancer Presenting as Acute Mastitis in a Patient One Month Postpartum
Am Surg. 2024 Mar 24:31348241241736. doi: 10.1177/00031348241241736. Online ahead of print.ABSTRACTInflammatory breast cancer (IBC) is a rare yet aggressive form of invasive ductal carcinoma, with a poor prognosis and decreased 5-year survival rates. Characteristic findings for IBC include rapid onset of breast edema, peau d'orange appearance, and involvement of the breast skin. Additionally, diagnosis is confirmed with a skin punch biopsy. With such nonspecific features, IBC can be mistaken for benign etiologies, causing delays in diagnosis and treatment. This patient is a 44-year-old woman presenting with left breast swe...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: Ananya Seth Eliza M Slama Source Type: research
Intra and peritumoral PET radiomics analysis to predict the pathological response in breast cancer patients receiving neoadjuvant chemotherapy
CONCLUSIONS: Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.PMID:38527731 | DOI:10.1016/j.remnie.2024.500002 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2024 Category: Molecular Biology Authors: Ay şegül Aksu G üç Zeynep Gülsüm Kadir Alper K üçüker Ahmet Alacac ıoğlu B ülent Turgut Source Type: research
Electrochemiluminescence biosensor for specific detection of pancreatic ductal carcinoma through dual targeting of MUC1 and miRNA-196a
Biosens Bioelectron. 2024 Mar 22;254:116241. doi: 10.1016/j.bios.2024.116241. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) poses significant diagnostic challenges due to its asymptomatic nature in its early stages, low specificity of conventional in vitro assays, and limited efficacy of surgical interventions. However, clinical specificity of the current serum biomarkers is suboptimal, leading to diagnostic inaccuracies and oversights. Therefore, this study introduced a novel dual-target electrochemiluminescence (ECL) biosensor to address these critical issues. The ECL biosensor synergistically emp...
Source: Biosensors and Bioelectronics - March 25, 2024 Category: Biotechnology Authors: Yuxuan Chen Zhuoxin Ye Mo Ma Jukun Yang Ruiyan Liu Yan Zhang Pinyi Ma Daqian Song Source Type: research
Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports
ConclusionsWe observed two cases of recurrent severe hypocalcemia in patients with advanced breast cancer and bone metastases after modifications to their therapy regimens. These cases differed from the typical hypocalcemia induced by bone-modifying agents. It is possible that antitumor drugs affect calcium and bone metabolism associated with bone metastases. While these cases are rare, it is crucial for oncologists to be aware of hypocalcemia not only at the initiation of bone-modifying agents but also throughout the entire antitumor therapy, as hypocalcemia can lead to fatal outcomes. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 25, 2024 Category: General Medicine Source Type: research
