Breast Cancer Subtypes: Clinicopathologic Features and Treatment Considerations
AbstractPurpose of reviewThe purpose of this review is to provide an overview of ten unique breast cancer subtypes and their clinicopathologic features and treatment implications.Recent findingsRecent findings show that while many subtypes (mucinous, papillary, tubular, apocrine) have favorable biology, with better overall survival than invasive ductal carcinoma, some (metaplastic, adenoid cystic) are more aggressive portending worse prognosis for patients.SummaryThe differences in histology represented in these breast cancer subtypes often impacts biology, behavior, and prognosis. Due to their rarity, additional research ...
Source: Current Breast Cancer Reports - March 26, 2024 Category: Cancer & Oncology Source Type: research

Delayed Diagnosis of Inflammatory Breast Cancer Presenting as Acute Mastitis in a Patient One Month Postpartum
Am Surg. 2024 Mar 24:31348241241736. doi: 10.1177/00031348241241736. Online ahead of print.ABSTRACTInflammatory breast cancer (IBC) is a rare yet aggressive form of invasive ductal carcinoma, with a poor prognosis and decreased 5-year survival rates. Characteristic findings for IBC include rapid onset of breast edema, peau d'orange appearance, and involvement of the breast skin. Additionally, diagnosis is confirmed with a skin punch biopsy. With such nonspecific features, IBC can be mistaken for benign etiologies, causing delays in diagnosis and treatment. This patient is a 44-year-old woman presenting with left breast swe...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: Ananya Seth Eliza M Slama Source Type: research

Delayed Diagnosis of Inflammatory Breast Cancer Presenting as Acute Mastitis in a Patient One Month Postpartum
Am Surg. 2024 Mar 24:31348241241736. doi: 10.1177/00031348241241736. Online ahead of print.ABSTRACTInflammatory breast cancer (IBC) is a rare yet aggressive form of invasive ductal carcinoma, with a poor prognosis and decreased 5-year survival rates. Characteristic findings for IBC include rapid onset of breast edema, peau d'orange appearance, and involvement of the breast skin. Additionally, diagnosis is confirmed with a skin punch biopsy. With such nonspecific features, IBC can be mistaken for benign etiologies, causing delays in diagnosis and treatment. This patient is a 44-year-old woman presenting with left breast swe...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: Ananya Seth Eliza M Slama Source Type: research

Intra and peritumoral PET radiomics analysis to predict the pathological response in breast cancer patients receiving neoadjuvant chemotherapy
CONCLUSIONS: Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.PMID:38527731 | DOI:10.1016/j.remnie.2024.500002 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2024 Category: Molecular Biology Authors: Ay şegül Aksu G üç Zeynep Gülsüm Kadir Alper K üçüker Ahmet Alacac ıoğlu B ülent Turgut Source Type: research

Electrochemiluminescence biosensor for specific detection of pancreatic ductal carcinoma through dual targeting of MUC1 and miRNA-196a
Biosens Bioelectron. 2024 Mar 22;254:116241. doi: 10.1016/j.bios.2024.116241. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) poses significant diagnostic challenges due to its asymptomatic nature in its early stages, low specificity of conventional in vitro assays, and limited efficacy of surgical interventions. However, clinical specificity of the current serum biomarkers is suboptimal, leading to diagnostic inaccuracies and oversights. Therefore, this study introduced a novel dual-target electrochemiluminescence (ECL) biosensor to address these critical issues. The ECL biosensor synergistically emp...
Source: Biosensors and Bioelectronics - March 25, 2024 Category: Biotechnology Authors: Yuxuan Chen Zhuoxin Ye Mo Ma Jukun Yang Ruiyan Liu Yan Zhang Pinyi Ma Daqian Song Source Type: research

Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports
ConclusionsWe observed two cases of recurrent severe hypocalcemia in patients with advanced breast cancer and bone metastases after modifications to their therapy regimens. These cases differed from the typical hypocalcemia induced by bone-modifying agents. It is possible that antitumor drugs affect calcium and bone metabolism associated with bone metastases. While these cases are rare, it is crucial for oncologists to be aware of hypocalcemia not only at the initiation of bone-modifying agents but also throughout the entire antitumor therapy, as hypocalcemia can lead to fatal outcomes. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 25, 2024 Category: General Medicine Source Type: research

Clinicopathological Predictors of Positive Resection Margins in Breast-Conserving Surgery
CONCLUSIONS: Compared with pure IBC, the relative risk of a positive margin with IBC + DCIS is approximately ninefold, significantly higher than prior estimates. This margin-level methodology is believed to represent the impact of DCIS more accurately on margin positivity in IBC.PMID:38520579 | DOI:10.1245/s10434-024-15153-8 (Source: Ann Oncol)
Source: Ann Oncol - March 23, 2024 Category: Cancer & Oncology Authors: Hemali Chauhan Natasha Jiwa Vikneswaran Raj Nagarajan Paul Thiruchelvam Katy Hogben Ragheed Al-Mufti Dimitri Hadjiminas Sami Shousha Ramsey Cutress Hutan Ashrafian Zoltan Takats Daniel Richard Leff Source Type: research

Clinicopathological Predictors of Positive Resection Margins in Breast-Conserving Surgery
CONCLUSIONS: Compared with pure IBC, the relative risk of a positive margin with IBC + DCIS is approximately ninefold, significantly higher than prior estimates. This margin-level methodology is believed to represent the impact of DCIS more accurately on margin positivity in IBC.PMID:38520579 | DOI:10.1245/s10434-024-15153-8 (Source: Ann Oncol)
Source: Ann Oncol - March 23, 2024 Category: Cancer & Oncology Authors: Hemali Chauhan Natasha Jiwa Vikneswaran Raj Nagarajan Paul Thiruchelvam Katy Hogben Ragheed Al-Mufti Dimitri Hadjiminas Sami Shousha Ramsey Cutress Hutan Ashrafian Zoltan Takats Daniel Richard Leff Source Type: research

Re-Evaluation of Ipsilateral Multiple-Focal Breast Cancer: Case Report and Literature Review
CONCLUSION: This case highlights the need for more evidence-based data to support risk-level stratification of heterogenous foci and treatment decisions for ipsilateral multiple breast cancer and challenges current clinical practice.PMID:38518165 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Lei Hou Ziyi Fan Luming Zheng Source Type: research

Re-Evaluation of Ipsilateral Multiple-Focal Breast Cancer: Case Report and Literature Review
CONCLUSION: This case highlights the need for more evidence-based data to support risk-level stratification of heterogenous foci and treatment decisions for ipsilateral multiple breast cancer and challenges current clinical practice.PMID:38518165 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Lei Hou Ziyi Fan Luming Zheng Source Type: research

Re-Evaluation of Ipsilateral Multiple-Focal Breast Cancer: Case Report and Literature Review
CONCLUSION: This case highlights the need for more evidence-based data to support risk-level stratification of heterogenous foci and treatment decisions for ipsilateral multiple breast cancer and challenges current clinical practice.PMID:38518165 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Lei Hou Ziyi Fan Luming Zheng Source Type: research

Long-term outcome of 9G MRI-guided vacuum-assisted breast biopsy: results of 293 single-center procedures and underestimation rate of high-risk lesions over 12  years
ConclusionOur results confirm that 1.5  T and 3 T MRI-guided VABB is an accurate and safe procedure for histopathologic final diagnosis of MRI-only lesions. Critical issues remain the potential high-risk underestimation rate of B3b VABB results and management of follow-up of benign lesions. (Source: La Radiologia Medica)
Source: La Radiologia Medica - March 21, 2024 Category: Radiology Source Type: research

Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
A woman in her late 70s was referred to urology clinic to consider intervention for a biopsy-proven 24 mm WHO/International Society of Urological Pathology (ISUP) grade 1 clear cell renal cell carcinoma (CCRCC) that was diagnosed 4 years prior and managed with active surveillance up to that point. The patient had a history of right invasive breast cancer (ductal carcinoma) first diagnosed more than 20 years ago and treated with wide local excision and adjuvant radiotherapy. She developed breast cancer recurrence in the scalp and chest wall 3 years before and was treated with letrozole, with satisfactory disease control. Fo...
Source: Journal of Clinical Pathology - March 20, 2024 Category: Pathology Authors: Hau, J., Briosa Neves, J., Varia, M. Tags: PostScript Source Type: research

Breast tissue imaging atlas using ultra-fast confocal microscopy to identify cancer lesions
The objective of the study was to create an atlas of ex vivo UFCM images of breast tissues and breast carcinomas based on the first extensive collection of large field-of-view UFCM breast images. One hundred sixty patients who underwent conserving surgery for breast cancer were included. Their fresh surgical specimens were sliced, stained with acridine orange, and imaged at high resolution with large-field-of-view UFCM. The resulting images were digitally false colored to resemble frozen sections. Each UFCM image was correlated with the corresponding definitive histology. Representative images of normal tissue, inflammatio...
Source: Virchows Archiv - March 19, 2024 Category: Pathology Source Type: research

Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research