Breast Cancer Screening: We Can Do Better
The three risk assessment tools now in use fall far short. Using the latest deep learning techniques, investigators are developing more personalized ways to locate women at high risk.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.The promise of personalized medicine will eventually allow clinicians to offer individual patients more precise advice on prevention, early detection and treatment. Of course, the operative word iseventually.A closer examination of the screening tools available to detect breast c...
Source: Life as a Healthcare CIO - August 31, 2021 Category: Information Technology Source Type: blogs
Evaluation of the Surgical Specimen After Neoadjuvant Systemic Therapy
ConclusionPostneoadjuvant systemic therapy histopathological changes are complex, and careful systematic review of the specimen is required for accurate diagnosis and follow-up treatment. For pathological complete response to be used as an indicator of response to novel therapies, it is essential to have a standardized way in which residual disease is measured and reported. We designed the recommendations specifically for the clinical trial setting; however, they can be optionally incorporated into routine practice because, in our opinion, standardization is most effective when uniformly applied. Hopefully, such standardiz...
Source: Oncopathology - March 23, 2021 Category: Cancer & Oncology Tags: breast Breast Biopsy Procedure breast cancer Source Type: blogs
More intensive treatment of DCIS reduces the risk of invasive breast cancer
This study showed that increased cancer risk persisted for more than 15 years after a diagnosis of DCIS, and that more intensive therapy than lumpectomy alone — whether with mastectomy, radiation therapy, or endocrine therapy — reduced the risk of invasive breast cancer among women with DCIS. The lowest risk of invasive breast cancer was in women who chose mastectomy.
The risk of invasive breast cancer was seen regardless of severity of DCIS. Women who had low- or moderate-grade DCIS, as well as high-grade DCIS, had long-term increased risk.
Women who are recently diagnosed with DCIS should work with their treatment te...
Source: Harvard Health Blog - January 19, 2021 Category: Consumer Health News Authors: Kathryn Rexrode, MD, MPH Tags: Breast Cancer Women's Health Source Type: blogs
Is it time to give up your annual mammogram?
If you dread your annual mammogram, you’re not alone. For many women, this breast cancer screening examination can be painful, stressful, and just an overall hassle.
You may wonder, are you old enough to give it up? If you’re over age 75, the answer is: maybe or maybe not. The fact is, breast cancer screening isn’t right for all older adults, but there’s no expert consensus on the right age to stop. This is mostly because scientific evidence in this area is lacking, says Dr. Kathryn Rexrode, associate professor of medicine at Harvard Medical School and chief of the Division of Women’s Health at Brigham and Womenâ...
Source: Harvard Health Blog - May 1, 2020 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Breast Cancer Healthy Aging Managing your health care Screening Women's Health Source Type: blogs
Microcalcification DCIS: Radiopath correlation
Microcalcifications result from the Calcium phosphate, usually in the form of calcium hydroxyapatite is more easily recognized in histopathology as it stains purple with haematoxylin and eosin. It is more commonly associated with malignant lesions than calcium oxalateFamous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - June 26, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
MRI is a Non-Invasive Way to Detect Hypoxia in Breast Cancer Patients
Hypoxia and neovascularization in breast cancer can now be identified using magnetic resonance imaging (MRI) techniques, according to a  studyrecently published inMolecular Imaging and Biology.Researchers from the Medical University of Vienna were intrigued by a couple of recently developed imaging methods that successfully analyzed hypoxia in patients with brain cancer and wanted to see if the same technology could be used to detect the condition in breast cancer patients. Advanced quantitative blood oxygenation level dependent (qBOLD) imaging can evaluate tissue oxygen and measure tumor hypoxia. Vascular architectural m...
Source: radRounds - February 1, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
Should You Get a Mammogram?
Leda Derderich wishes she had.
Dederich had stage IV breast cancer diagnosed at age 45, two years after she and her doctor discussed and dismissed the need for a routine screening mammogram while breastfeeding at age 43. That decision to delay screening mammograms may have meant that she lost the chance to find and treat her breast cancer before it had spread beyond the breast. It’s a decision she regrets now, and blames on the confusion around mammogram guidelines.
I have had a much harder time accepting that I was not screened for breast cancer before it was too late. Not because I couldn’t be bothered, was t...
Source: The Blog That Ate Manhattan - October 28, 2018 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Breast Cancer Mammography ACOG ACR ACS Guidelines mammogram Stage IV USPSTF Source Type: blogs
Should You Get a Mammogram?
Leda Derderich wishes she’d started having mammograms sooner.
Dederich had stage IV breast cancer diagnosed at age 45, two years after she and her doctor discussed and dismissed the need for a routine screening mammogram while breastfeeding at age 43. That decision to delay screening mammograms may have meant that she lost the chance to find and treat her breast cancer before it had spread beyond the breast. It’s a decision she regrets now, and blames on the confusion around mammogram guidelines.
I have had a much harder time accepting that I was not screened for breast cancer before it was too late. Not be...
Source: The Blog That Ate Manhattan - October 28, 2018 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Breast Cancer Mammography ACOG ACR ACS Guidelines mammogram Stage IV USPSTF Source Type: blogs
Bi-annual MRI More Effective than Annual Mammogram for Breast Cancer Detection
This study could significantly change the way we approach breast cancer screening." MRI is much more sensitive than mammography, " Â saidGreg Karczmar, PhD, professor of radiology at the University of Chicago. " It can find invasive breast cancers sooner than mammograms and it can rule out abnormalities that appear suspicious on a mammogram. Unfortunately, MRI is much too expensive for routine screening. " (Source: radRounds)
Source: radRounds - September 20, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
What's in a name?
From time to time I have commented on the controversies over cancer screening. Most people assume that screening is an unqualified good, that early detection of cancer saves lives. Whenever some panel proposes recommending less screening, we hear screaming and yelling from advocates who claim they are trying to " ration " health care to save money at the expense of people ' s lives.In fact,as a bunch of Australians and a Minnesotan explain in BMJ, there are a few conditions called " cancer " that you are better off not treating, or perhaps treating very conservatively. These include what is called ductal carcinoma in situ ...
Source: Stayin' Alive - August 13, 2018 Category: American Health Source Type: blogs
Rethinking the screening mammogram
This study analyzed data from women over 40 and compared the size of breast cancers at the time of diagnosis detected in the 1970s (before mammography became common) with the size of tumors detected between 2000 and 2002, when screening mammography was routine. Treatments and rates of death due to breast cancer 10 years after the diagnosis were also analyzed. The study found that:
As more women underwent routine screening mammograms, more small breast cancers were detected. Many of these tumors were restricted to the ducts within the breast (called ductal carcinoma in situ), and even without treatment would never threaten...
Source: Harvard Health Blog - June 28, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Source Type: blogs
Tumor Size (Size of Invasive Carcinoma) in Breast Carcinoma
Breast Carcinoma reporting;Tumor Size (Size of Invasive Carcinoma)The size of an invasive carcinoma is an important prognostic factor. The single greatest dimension of the largest invasive carcinoma is used to determine T classification The best size for AJCC T classification should use information from imaging, gross examination, and microscopic evaluation. Visual determination of size is often unreliable, as carcinomas often blend into adjacent fibrous tissue. The size by palpation of a hard mass correlates better with invasion of tumor cells into stroma with a desmoplastic response. Sizes should...
Source: Oncopathology - April 12, 2018 Category: Cancer & Oncology Source Type: blogs
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Methods for estimating the size/extent of DCIS inspecimen.Why to measure size of DCIS in specimen:Higher rates of invasive cancer detected according to DCIS size. Progression to invasive cancer occurred in 10% of DCIS patients with a DCIS tumor size between 2.5 to 3.5 cms, 57% for tumor size 3.6 to 4.5 cms and 71% for tumors between 4.5 and 6 cms.Tumors over 2.5 cms have a higher risk of progressing to invasive cancers.J Exp Clin Cancer Res. 2006 Jun;25(2):223-7.There are multiple methods for estimating the extent of DCIS (see Figure):DCIS in 1 block: The area involved by DCIS can be measured from a single slide...
Source: Oncopathology - March 28, 2018 Category: Cancer & Oncology Source Type: blogs
