Fight Aging! Newsletter, January 29th 2018
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities.
Delivery of Extracellular Vesicles as a Potential Basis for Therapies
https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/
Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harvest...
Source: Fight Aging! - January 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Even Modest Changes in Calorie Intake and Weight can Ruin any Study of Health
Calorie restriction has a large beneficial effect on health and longevity in mice, and as a result any number of studies carried out over the past century were ruined - usually without the researchers noticing - because no attempt was made to control for calorie intake and weight. Any treatment that causes nausea in mice, and thus a lower calorie intake, may have mistakenly reported benefits. Any treatment that resulted in mice eating more may have mistakenly missed benefits or reported harms.
The same general principle applies for people running their own self-experiments of treatments that might slow or turn back ...
Source: Fight Aging! - January 22, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
True about LGE scar – Cardiology MCQ
True statement/s about LGE (late gadolinium enhancement) in cardiac magnetic resonance imaging for scar in ventricular tachycardia:
Ischemic scars are predominantly subendocardial
Post inflammatory scars are predominantly sub epicardial
Scar in dilated cardiomyopathy is located in the mid wall region
All of the above
Post your answer as a comment below
Correct answer will be published on Dec 27, 2017 @ 18:00
(Source: Cardiophile MD)
Source: Cardiophile MD - December 25, 2017 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiac Magnetic Resonance imaging Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Cardiology MCQ Test 5
Time limit: 0
Quiz-summary
0 of 20 questions completed
Questions:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
...
Source: Cardiophile MD - October 22, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Cardiology MCQ Test 4
Time limit: 0
Quiz-summary
0 of 20 questions completed
Questions:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
...
Source: Cardiophile MD - October 21, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Evidence for Cellular Senescence to be Involved in Cardiac Hypertrophy
In this open access paper, evidence is presented for senescent cells to be involved in the development of age-related cardiac hypertrophy, detrimental changes in the structure of the heart. The results here are somewhat more speculative than much of the recent evidence for cellular senescence to contribute to specific age-related conditions, most of which is direct and robust. Firstly the authors are arguing for senescence to be a relevant mechanism in a cell population that largely doesn't replicate, and therefore will not be generating large numbers of transient senescent cells as somatic cells hit the Hayflick limit. Fe...
Source: Fight Aging! - August 10, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A patient with shortness of breath
This 50-something with a history of alcohol abuse complained of 2 weeks of increasing dyspnea for 2 weeks, with some chest pain and cough. She was not ill-appearing.Her BP was 111/68, with a heart rate of 117, RR 22, Temp 36.4 C and SpO2 of 95%.She had a routine ECG performed at triage, as we do with all patients who are SOB.What do you think?I was brought this ECG and asked what I thought.I responded: there is very low voltage and tachycardia, does the ultrasound show an effusion?Here is the ED point of care ultrasound:There is a huge effusion with collapse of the RV. This is diagnostic of tamponade.A pigtail ca...
Source: Dr. Smith's ECG Blog - June 10, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, April 17th 2017
This study assessed the prevalence of grey hair in patients with coronary artery disease and whether it was an independent risk marker of disease.
This was a prospective, observational study which included 545 adult men who underwent multi-slice computed tomography (CT) coronary angiography for suspected coronary artery disease. Patients were divided into subgroups according to the presence or absence of coronary artery disease, and the amount of grey/white hair. The amount of grey hair was graded using the hair whitening score: 1 = pure black hair, 2 = black more than white, 3 = black equals white, 4 = white more t...
Source: Fight Aging! - April 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Promising Results from an Early Trial of a Stem Cell Heart Patch
Heart patches are one manifestation of the tissue engineering approach to regenerative medicine. Cells delivered to the patient are usually combined with a biodegradable scaffold material that provides support to help the cells survive and undertake beneficial signaling actions. A heart patch is some amount of this combined material applied to the exterior of the heart, in some cases simply by injection since the scaffold can be made to be a viscous fluid. The researchers here claim better results by abandoning the scaffolds, however, and implanting thin sheets of engineered cells. This paper reports on the results of an e...
Source: Fight Aging! - April 10, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dilated cardiomyopathy review in Circulation
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - February 5, 2017 Category: Internal Medicine Tags: cardiovascular Source Type: blogs
All about alternans
Here is all you wanted to know about alternans: Traube’s pulse, total pulsus alternans, diastolic pulsus alternans, right ventricular pulsus alternans, biventricular pulsus alternans and electrical alternans!
Traube’s pulse – pulsus alternans
Pulsus alternans or Traube’s pulse was described by Ludwig Traube in 1872 [1]. Pulsus alternans is nothing but alternating pulses having different volumes and is a feature of left ventricular dysfunction. It is well known that pulsus alternans can be augmented by a premature ventricular contraction [2].
A rare case of pulsus alternans due to 2:1 left bundle branch...
Source: Cardiophile MD - January 25, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology biventricular pulsus alternans Brody's effect diastolic pulsus alternans electrical alternans right ventricular pulsus alternans total pulsus alternans Traube's pulse Source Type: blogs
Cardiomyopathy Quiz
Short quiz on cardiomyopathy
Cardiomyopathy Quiz
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.
If loading fails, click here to try again
Congratulations - you have completed Cardiomyopathy Quiz.
You scored %%SCORE%% out of %%TOTAL%%.
Your performance has been rated as %%RATING%%
Your answers are highlighted below.
Question 1AV block in the presence of features of dilated cardiomyopathy (DC...
Source: Cardiophile MD - December 10, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
AICD use in patients with non-ischemic dilated cardiomyopathy
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - December 9, 2016 Category: Internal Medicine Tags: cardiovascular Source Type: blogs
BAG3 as a Target to Reduce Reperfusion Injury in Heart Tissues
There have been a number of life science discoveries of late that might lead to therapies capable of reducing the level of tissue damage caused by structural failures in important blood vessels, the basis for a range of age-related conditions. News of another possible approach arrived recently, and you will find links to the publicity materials and open access paper below. Blood vessel failures cause an interruption of oxygenated blood flow to tissues, and depending on the location in the body and size of the failed vessel, can produce the dramatic symptoms of stroke, heart attack, and so forth. While methods of prevention...
Source: Fight Aging! - November 18, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
