Fight Aging! Newsletter, January 29th 2018
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harvested from, say, some form of stem cell, and then delivered to a patient. One of the ways in which stem cell therapies might branch and evolve in the near future is to discard the cells themselves in favor of the signals produced by those cells. The evidence to date strongly suggests that many of the current forms of cell therapy produce their beneficial effects, such as a reduction in inflammation, via signaling. The cells themselves do not survive for long enough in large enough numbers to be making a difference through other activities. This is not to say that all cell therapies should be replaced by signals - in most of the cases relevant to human rejuvenation, it is vital to deliver cells that stick around, integrate with tissues, and perform all of the necessary tasks required of them. To augment a failing organ such as the heart that is not natural...
Contributors : Heather Machkovech ; Arvind SubramaniamSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCellular stress is often accompanied by non-canonical initiation of translation at alternate start codons in mammalian cells. Here we systematically investigate the extent and impact of alternate translation initiation in the context of influenza virus infection. We use ribosome profiling with the initiation inhibitor lactidomycin to experimentally delineate translation initiation sites in a human lung epithelial cell line infected with influenza virus.
Another Nod From Nature Scientific ReportsPublications referencing use of our antibodies continue to build. We are recognized for having potentNeuropeptide Antibodies.This most recent publication references ourGuinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, V éronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-yFigure: Distribution of the Cre-GFP in t...
The thumbnail take on finasteride has been that it prevents prostate cancer but increases the risk for high-grade disease. A new study debunks the latter idea.Medscape Medical News
CONCLUSIONS: The PHT has the potential to be substituted for manual interpretation of the HTT and to serve in a variety of clinical and research applications. PMID: 29775421 [PubMed - in process]
Smart technologies can sift through data to help the NHS spot diseases quicker, the PM is to say.
LONDON (Reuters) - Prime Minister Theresa May will call on Britain's health service, charities and artificial intelligence sector to work together to better identify patients with the early stages of cancer and stop thousands dying each year.
This article will discuss those efforts and results to date. PMID: 29766832 [PubMed - as supplied by publisher]
This study assessed the survival impact of combined surgery to the primary tumor and metastatic disease in the management of metastatic NSCLC. Stage IV NSCLC patients at presentation, diagnosed from 2004 to 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. Propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TN stage, and site of metastases). A total of 144,334 patients were identified. The median age group was 65-70 years, and 1139 patients (0.8% of the patients) have received surgical treatment to both the primary tumor...
In conclusion, NSUN2 is a potential independent prognostic marker and may be a potential therapeutic target in HNSCC. PMID: 29775108 [PubMed - in process]
SLEEP is one of the most important activities of the day, and can help reduce your risk of developing conditions like dementia. However, getting enough can be difficult if your snoring keeps waking up you, and everyone nearby. Try these three tips to get some quiet shut-eye.
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