Fight Aging! Newsletter, January 29th 2018

In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harvested from, say, some form of stem cell, and then delivered to a patient. One of the ways in which stem cell therapies might branch and evolve in the near future is to discard the cells themselves in favor of the signals produced by those cells. The evidence to date strongly suggests that many of the current forms of cell therapy produce their beneficial effects, such as a reduction in inflammation, via signaling. The cells themselves do not survive for long enough in large enough numbers to be making a difference through other activities. This is not to say that all cell therapies should be replaced by signals - in most of the cases relevant to human rejuvenation, it is vital to deliver cells that stick around, integrate with tissues, and perform all of the necessary tasks required of them. To augment a failing organ such as the heart that is not natural...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Qiang Zhang, Wei Dou, Deng Pan, Er-Hu Chen, Jin-Zhi Niu, Guy Smagghe, Jin-Jun Wang
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 21 March 2019Source: Journal of Molecular LiquidsAuthor(s): Chandrabhan Verma, M.A. Quraishi, H. Lgaz, L.O. Olasunkanmi, El-Sayed M. Sherif, R. Salghi, Eno E. EbensoAbstractThe corrosion inhibition potentials of some derivatives of 2-((1H-indol-2-yl)thio)-6-amino-4-phenylpyridine-3,5-dicarbonitrile (TAPD) namely 2-(1H-indol-2-ylthio)-6-amino-4-(4-nitrophenyl)pyridine-3,5-dicarbonitrile (TAPD-I), 2-((1H-indol-2-yl)thio)-6-amino-4-phenylpyridine-3,5-dicarbonitrile (TAPD-II), and 2-(1H-indol-2-ylthio)-6-amino-4-(4-hydroxyphenyl)pyridine-3,5-dicarbonitrile (TAPD-III) on mild steel in 1 M HC...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Pourseyed Aghaei Fatematossadat, Mahnaz Mohammadi, S. Ehsan RoozmehAbstractIn this paper, we study magnetic and structural properties of silver and gold-coated iron nanoparticle as novel drug delivery systems for the two commercially famous cancer treatment drugs, using the density functional theory (DFT) computations.Our calculations show that silver and gold-coated iron nanoparticle have magnetization and the magnetic moment of the Fe atom in the Fe@(Ag/Au)n core-shells saturated to a value of about 3 μB. Thus...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 22 March 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): D. Martínez-Moreno, G. Jiménez, P. Gálvez-Martín, G. Rus, J.A. MarchalAbstractOsteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
This study demonstrates that CCL2 is a key molecule for the development of metabolic and histological alterations in the liver of mice sensitive to the development of hyperlipidemia and hepatic steatosis, a finding with potential to identify new therapeutic targets in liver diseases.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 March 2019Source: Life SciencesAuthor(s): Junge Zhu, Shanshan Dou, Yunlu Jiang, Bo Bai, Jing Chen, Chunmei Wang, Baohua ChengAbstractAimsParkinson's disease (PD) is a common neurodegenerative disease typically associated with the accumulation of α-synuclein. Autophagy impairment is thought to be involved in the dopaminergic neurodegeneration in PD. We investigate the effect of Apelin-36 on the activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B(Akt)/the mammalian target of rapamycin (mTOR) autophagy pathway in 1-methyl-4-phenylpyridinium (MPP+)-treated SH-SY5Y cells, ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we established a myocardial infarction (MI) animal model derived from OVX C57BL/6 female mice, and investigated the effect of G1 on cardiac function by echocardiography and Hemodynamics, morphology and expression of fibrosis-related and apoptosis-related proteins by Masson's trichrome and H&E, Immunofluorescence, Western blotting and TUNEL.Key findingsCombination with OVX significantly increased myocardial fibrosis and MI area compared to MI treatment alone, as determined by echocardiography and hemodynamics. Further addition of G1 changed the expression of apoptosis-related proteins, decreased the levels of...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 21 March 2019Source: Carbohydrate PolymersAuthor(s): Ningxiang Yu, Xiaoya Wang, Fangjian Ning, Chengjia Jiang, Yanbin Li, Hailong Peng, Hua XiongABSTRACTThe fruit of Akebia trifoliata var. australis can be consumed as food. However, the peel of this fruit is typically regarded as waste. The application of such waste can create opportunities to produce new and valuable by-products. Herein, we have shown that citric acid extracted pectin (CEP) from Akebia trifoliata var. australis peel has good water solubility and high galacturonic units, which helps reduce AgNO3 into Ag nanoparticles (CEP...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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