Impaired Monocyte to Macrophage Transition Implicated in Cardiovascular Disease
The innate immune cells called macrophages are vitally important to the health and function of tissues. They help to coordinate the intricate dance of stem cells, somatic cells, and immune cells that produces tissue regrowth and tissue maintenance. They destroy errant cells and pathogens. They have a variety of other roles as well. But where do macrophages come from? While some macrophages are generated within tissues, it is generally the case that in damaged or diseased tissues, most macrophages were originally monocytes. Circulating monocytes in the bloodstream enter tissues in response to chemical cues and then transfor...
Source: Fight Aging! - July 29, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Diagnostic criteria for peripartum cardiomyopathy
Diagnostic criteria for peripartum cardiomyopathy are:
Development of heart failure in the last month of pregnancy or within 5 months after delivery
Left ventricular systolic dysfunction with ejection fraction less than 45%
No other identifiable cause for heart failure
No recognized heart disease before the last month of pregnancy
Reference
van Spaendonck-Zwarts KY1, van Tintelen JP, van Veldhuisen DJ, van der Werf R, Jongbloed JD, Paulus WJ, Dooijes D, van den Berg MP. Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25;121(20):2169-75. (Source: Cardiophile MD)
Source: Cardiophile MD - May 21, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, May 20th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - May 19, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rejuvenate Bio to Launch a Gene Therapy Trial for Heart Failure in Dogs
One of the many possible paths towards developing a new medical technology is to first focus on veterinary use. It is considerably less costly in time and resources to develop a therapy for dogs, say, than it is to develop a therapy for humans. Later, given robust success in veterinary medicine, the therapy can be brought into the sphere of human medicine. This is the approach taken by Rejuvenate Bio for their class of regenerative gene therapies. As noted here, the company is moving forward to trials in companion animals, starting later this year.
Back in 2015, the Church lab at Harvard began testing a variety of...
Source: Fight Aging! - May 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parent...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MicroRNAs Assist in Heart Regeneration
Many researchers are exploring the therapeutic utility of microRNAs involved in fundamental cellular processes such as replication. These molecules act to regulate the processes of gene expression, determining how much of specific proteins are produced from their genetic blueprints, and when. Protein amounts are the switches and dials of cellular operation, and delivering microRNAs into cells is one possible way to steer cells into useful behavior - through the sheer complexity of the cell makes identifying the right tools to use quite difficult, and any given microRNA may produce quite sweeping changes, only few of which ...
Source: Fight Aging! - April 26, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Investigations and management of dilated cardiomyopathy
Investigations in dilated cardiomyopathy
Chest X-ray PA view will assess the cardiac size in dilated cardiomyopathy and show evidence of pulmonary congestion. Sick persons may present with features of frank pulmonary edema in the form of hilar haze or bat wing pattern of pulmonary edema. Significant left ventricular dysfunction can exist without much of cardiomegaly on chest X-ray as well.
ECG may show sinus tachycardia, left atrial overload and sometimes left ventricular hypertrophy. A wide QRS complex with left bundle branch block pattern may indicate potential benefit from cardiac resynchronization therapy (CRT). ECG ...
Source: Cardiophile MD - March 30, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs
Heart failure with false negative BNP – Cardiology MCQ
Heart failure with false negative BNP – Cardiology MCQ
In which of the following conditions with heart failure can false negative BNP (B-type natriuretic peptide) values occur?
Myocardial infarction
Dilated cardiomyopathy
Mitral stenosis
Mitral regurgitation
Post your answer as a comment below (Source: Cardiophile MD)
Source: Cardiophile MD - March 29, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
12 Year Old Asthmatic with Intermittent Dyspnea Unresponsive to Albuterol---What is it, and Why Now?
This case was written by one of ourgreat Hennepin 2nd year residents, Aaron Robinson, with lots of comments and edits by Smith.Thanks to Dr. Smith and Dr. Travis Olives for being part of this case. A 12 year old girl with a history of mild intermittent asthma presented to the emergency department with worsening shortness of breath over the past couple of days. She is up to date on her vaccinations and has no PMHx besides asthma and a noncontributory family history. She does not identify any specific triggers for her asthma. Initial screen in triage revealed normal vitals signs and a normal temperature. Upon interviewi...
Source: Dr. Smith's ECG Blog - August 7, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
Friendly Infarcts in ACS : Ischemic mitral regurgitation and the Papillary muscle paradox !
Ischemic MR is a critical entity in determining the long-term survival in post MI patients as well as dilated cardiomyopathy. (Originally described by J. H. Philips Ann Intern Med. 1963;59(4):508-520)
The mechanism of MR can really be complex .We know mitral apparatus consists of six components.The sub valvular apparatus plays a key role. LV free wall especially the inferior and lateral segments which subtends the two papillary muscle has a critical role in maintaining the mitral valve competency .
There seems to me a complex mechano -anatomical behavior of subvalvular structures in progressive LV dysfunction e...
Source: Dr.S.Venkatesan MD - July 18, 2018 Category: Cardiology Authors: dr s venkatesan Tags: Dilated cardiomyopathy Mitral regurgitation mechanism of ischemic mitral regurgitation papillary muscle dysfunction Source Type: blogs
As CABANA waves a final good bye to catheters in AF . . . let the pulmonary veins rejoice !
There is a tough ongoing rivalry between drugs and catheters to conquer the commonest electrical chaos in human heart, namely Atrial fibrillation (AF). Mind you,the confusion about the importance of this arrhythmia is huge and real.Bulk of these episodes are transient , paroxysmal and do not require rigorous management.While stroke prevention seems to be the major aim and target , the real world scenario seems to tell a different story.
The nomenclature conundrum
AF may be classified as many ways a learned cardiologists can think . Often it’s done with reference to etiology, duration , rate, neural (sympathetic o...
Source: Dr.S.Venkatesan MD - May 31, 2018 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized ACC AHA ESC guidelines for AF affirm race cabana amiodarone for atrial fibrillation CABANA trial carto pulmonary vein ablations cryo balloon for af ablation heart rhythm society atrial fibrillation guidelines rate vs rhythm c Source Type: blogs
Chest pain, Ventricular Paced Rhythm, and a Completely Normal Angiogram 3 Months Prior.
One of our graduates, Rochelle Zarzar, who is now an education fellow, sent me this from one of the hospitals she works at now:An elderly woman presented with chest pain. She had been nauseous the night before and did not feel well, then awoke 2 hours prior with chest pain.She had had a completely normal angiogram 3 months prior.Here is that angiogram report:The left main coronary artery is normal.Left anterior descending is a type 3 vessel and is normal.Left circumflex is nondominant and normal.The right coronary artery is dominant and normal.The nurses immediately recorded an ECG. This was 2 hours after the o...
Source: Dr. Smith's ECG Blog - May 29, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, May 7th 2018
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Heart r...
Source: Fight Aging! - May 6, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Higher Levels of Progerin are Found in Cardiomyopathy Patients
Hutchinson-Gilford progeria syndrome (HGPS), or simply progeria, is a rare genetic condition that presents the superficial appearance of greatly accelerated aging. It isn't in fact accelerated aging, but rather one specific form of molecular damage run amok, causing severe and increasing dysfunction in near all cells. Normal aging is a collection of many varied forms of molecular damage that eventually cause severe and increasing dysfunction in near all cells. The consequences of a failure of any given population of cells or an organ to function correctly can appear superficially similar even if the causes are not the same...
Source: Fight Aging! - May 3, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
MyoKardia Develops Machine Learning Algorithm For Prediction of Hypertrophic Cardiomyopathy Using Wearable Biosensor: Interview
In this study, we collected PPG pulse wave traces from patients with oHCM and healthy volunteers. Using automated analyses, we extracted details about the shape and pattern of the tracings and applied machine learning to identify differences in these features between oHCM patients and healthy volunteers. We found that a sensitive and specific signature of arterial blood flow in oHCM could be identified with the combination of a wrist-worn PPG biosensor and machine learning algorithms.
Medgadget: Have you compared the results of the biosensor created by Wavelet Health with results collected from another similar PPG d...
Source: Medgadget - February 8, 2018 Category: Medical Devices Authors: Alice Ferng Tags: Cardiology Exclusive Source Type: blogs
