Impaired Monocyte to Macrophage Transition Implicated in Cardiovascular Disease

The innate immune cells called macrophages are vitally important to the health and function of tissues. They help to coordinate the intricate dance of stem cells, somatic cells, and immune cells that produces tissue regrowth and tissue maintenance. They destroy errant cells and pathogens. They have a variety of other roles as well. But where do macrophages come from? While some macrophages are generated within tissues, it is generally the case that in damaged or diseased tissues, most macrophages were originally monocytes. Circulating monocytes in the bloodstream enter tissues in response to chemical cues and then transform into macrophages that set to work to try to aid in repair and regeneration. Monocytes themselves are generated by cell populations in the bone marrow that descend from hematopoietic stem cells. At any given time about half of the monocytes in the body reside in the spleen, acting as a reserve that can leap into action when required. Thus in any given situation of injury or disease in which the presence of macrophages would be beneficial, any process that prevents monocytes from arriving and transforming into macrophages will make things worse. Interestingly, it isn't always the case that more macrophages will improve the situation. Atherosclerosis, for example, is a condition in which fatty lesions that narrow and weaken blood vessels form because the macrophages responsible for repairing the problem become overwhelmed by cholesterol and die, adding...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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AbstractMyasthenia gravis (MG) is an autoimmune disease characterised by the presence of acetylcholine receptor antibodies and by blocking the transmission of the signal in the neuromuscular junction causing muscle weakness. It can be associated with several autoimmune diseases and certain drugs, between them Etanercept an anti-tumour necrosis factor (TNF) agent. A 42-year-old woman with rheumatoid arthritis (RA) refractory to methotrexate, was treated with adalimumab (ADA), a human monoclonal antibody against the TNF, in a dosage scheme of 40  mg every 14 days subcutaneously. The patient responded well to ADA th...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractAutoimmune syndrome induced by adjuvants (ASIA) is the spectrum of diseases in which the substances considered inert to the body induce autoimmune reactions and inflammation. Some of the biomaterials recently used in plastic surgery, such as silicone or polyacrylamide hydrogel (PAAG) seem to trigger clinical features of ASIA. The aim of this study was to assess the incidence of these features within a group of women after breast augmentation with PAAG. As many as 30 consecutive patients (26 –59 years, mean age 39.5) referred to the Clinic of Plastic Surgery after breast enhancement with PAAG were examine...
Source: Rheumatology International - Category: Rheumatology Source Type: research
We present two siblings, 13-year-old girl and 25-year-old boy with SPENCD, from consanguineous parents. Both patients had short stature, platyspondyly, metaphyseal changes, spastic paraparesis, mild intellectual disability, and juvenile-onset SLE. The age at disease-onset was 2  years for girl and 19 years for boy. Both had skin and mucosa involvement. The age at diagnosis of SLE was 4 years for girl, and 19 years for boy. The clinical diagnosis of SPENCD was confirmed by sequencing ofACP5 gene, which revealed a homozygous c.155A  >  C (p.K52T), a variant reported before as pathogenic. ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the worldwide population. RA is associated with multiple extra-articular manifestations (EAMs). Middle ear, cochlea and the auditory nerve are suspected sites of RA activity and hearing loss is a possible novel EAM of RA. Objective was to investigate the association of RA with the different subtypes of hearing loss. This systematic review was performed according to the PRISMA guidelines. A random effects model meta-analysis was conducted and theI2 was used to assess heterogeneity. Twelve studies comprising 20,022 RA patients and 79,244...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractRepurposing of antirheumatic drugs has garnered global attention. The aim of this article is to overview available evidence on the use of widely used antirheumatic drugs hydroxychloroquine, methotrexate and colchicine for additional indications. Hydroxychloroquine has endothelial stabilizing and anti-thrombotic effects. Its use has been explored as an adjunctive therapy in refractory thrombosis in antiphospholipid syndrome. It may also prevent recurrent pregnancy losses in the absence of antiphospholipid antibodies. Hydroxychloroquine favourably modulates atherogenic lipid and glycaemic profiles. Methotrexate has b...
Source: Rheumatology International - Category: Rheumatology Source Type: research
HOW TO live longer: Prevent an early death by eating a healthy, balanced diet, and by doing regular exercise. But you could also increase your life expectancy by adding more low-fat yoghurt for breakfast. It could even lower your risk of developing heart disease symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION Bilobed transposition flaps are versatile repairs for extranasal reconstruction with a favorable safety and outcome profile.
Source: Dermatologic Surgery - Category: Dermatology Tags: Original Article Source Type: research
No abstract available
Source: Dermatologic Surgery - Category: Dermatology Tags: Reconstructive Conundrum Source Type: research
Publication date: December 2020Source: IJC Heart &Vasculature, Volume 31Author(s): Jani Rankinen, Petri Haataja, Leo-Pekka Lyytikäinen, Heini Huhtala, Terho Lehtimäki, Mika Kähönen, Markku Eskola, Andrés Ricardo Pérez-Riera, Antti Jula, Teemu Niiranen, Kjell Nikus, Jussi Hernesniemi
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Publication date: Available online 25 September 2020Source: American Heart JournalAuthor(s): Alex F Grubb, Christopher A Pumill, Stephen J Greene, Angie Wu, Karen Chiswell, Robert J Mentz
Source: American Heart Journal - Category: Cardiology Source Type: research
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