Long working hours – masked and sustained hypertension
Long working hours – masked and sustained hypertension
Long working hours has been shown to give rise to masked and sustained hypertension in a recent study published in the journal Hypertension from the American Heart Association [1]. Study data was collected over 5 years from over 3500 white collar workers.
Workplace clinic blood pressure was the mean of first three readings taken at workplace during rest. Ambulatory blood pressure was the mean of daytime recordings taken every 15 minutes during working hours. When the clinic blood pressure was below 140/90 mm Hg and ambulatory blood pressure was 135/85 mm Hg or...
Source: Cardiophile MD - December 21, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, December 9th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - December 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Latest on Cellular Senescence in Type 2 Diabetes
One of the more unexpected recent findings relating to cellular senescence is that it appears to be an important part of the mechanisms that lead to loss of the pancreatic β-cells responsible for insulin secretion in both type 1 diabetes and type 2 diabetes - which are very different conditions, despite the shared name. The authors of the brief open access commentary noted here discuss the present state of this research.
Age is one of the major risk factors for the development of type 2 diabetes mellitus (T2D). However, the understanding of how cellular aging contributes to diabetes pathogenesis is incomplete and...
Source: Fight Aging! - December 5, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 67-year-old man with a carotid bruit
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 67-year-old man is evaluated for a carotid bruit detected on routine medical examination. He reports no history of previous focal neurologic symptoms or visual loss. He has type 2 diabetes mellitus and hyperlipidemia treat ed with metformin, moderate-intensity pravastatin, and aspirin. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 23, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Cardiology Source Type: blogs
Fight Aging! Newsletter, October 7th 2019
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone.
Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the...
Source: Fight Aging! - October 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing AGEs and ALEs in Oxidative Stress and Aging
Advanced glycation end products (AGEs) and the less discussed advanced lipoxidation end products (ALEs) are an interesting topic in the context of aging. There are in fact two distinct topics here. The first is the presence of persistent cross-links, in which glucosepane AGEs form links between extracellular matrix molecular, degrading the structural properties of tissue, particularly elasticity. These cross-links, arising from the normal operation of metabolism, are resilient and not broken down by our biochemistry. Some form of biotechnology, such as therapies based on enzymes mined from bacterial species that can metabo...
Source: Fight Aging! - October 3, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Using FibroScan in The Clinic: Interview with Dr. Stephen A. Harrison
EchoSens creates non-invasive liver diagnosis medical devices. The company’s line of products, called FibroScan, work by measuring the speed of ultrasound waves as they move through liver tissue. This measurement can tell us about the state of the liver. For example, ultrasound waves move faster through fibrotic/scarred livers. EchoSens recently appointed Dominique Legros as their new global CEO, and we recently spoke about his plans for growth in a Medgadget exclusive.
To learn more about how a clinician would use the FibroScan, we spoke with Dr. Stephen A. Harrison, Medical Director of Pinnacle Clinical Re...
Source: Medgadget - September 30, 2019 Category: Medical Devices Authors: Ben Ouyang Tags: Diagnostics Exclusive GI Medicine Source Type: blogs
Fight Aging! Newsletter, September 30th 2019
In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
Source: Fight Aging! - September 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Alzheimer's Disease as a Condition of Many Subtypes and Contributing Causes
Neurodegeneration in late life is a very complex phenomenon, and its complexity strains against the nice neat clinical definitions of disease found in the textbooks. Different patients with Alzheimer's disease can exhibit quite different mixes of various forms of pathology, developing at different paces and times: aggregates of amyloid-β, tau, and α-synuclein; vascular degeneration; markers of neuroinflammation; metabolic disruption similar to that of diabetes, and so forth. One case of Alzheimer's might be different enough from another to require a different designation. Thus researchers talk about defining subtypes of ...
Source: Fight Aging! - September 27, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
RAGE and Chronic Inflammation in Aging
Chronic inflammation is a very important downstream consequence of molecular damage in the progression of aging, arising from numerous causes. The past decade of work on the presence of lingering senescent cells in old tissues indicates that their signaling is significant cause. In animal studies, removing senescent cells can reverse the course of many age-related and other conditions that are primarily inflammatory in nature. Visceral fat tissue in excess amounts can accelerate the production of senescent cells, but it also generates inflammation through other mechanisms, such as debris from dead cells, signaling by non-s...
Source: Fight Aging! - September 24, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
MKSAP: 49-year-old-man with right arm weakness
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 49-year-old-man is evaluated 1 day after having an episode of right arm weakness without pain that lasted 5 minutes. He is now asymptomatic. The patient has type 2 diabetes mellitus and dyslipidemia. Medications are aspiri n, metformin, and atorvastatin. On physical […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 24, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Neurology Source Type: blogs
MKSAP: 45-year-old woman with type 2 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 45-year-old woman is evaluated for management of type 2 diabetes mellitus diagnosed 3 months ago. She was asymptomatic at diagnosis with an initial HbA1c value of 9.7%. Her initial interventions included lifestyle modifica tions with weight loss and metformin. She is […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 27, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Meds Diabetes Endocrinology Source Type: blogs
Kidney stones: What are your treatment options?
If you’ve been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy.
A brief anatomy of the urinary tract
The urinary tract includes
kidneys (two organs that filter waste and extra water from the blood)
ureters (two tubes bringing urine from each kidney to the bladder)
bladder (organ that collects urine)
urethra (a single tube through which urine in the bladder passes out of the body).
The evaluation for kidney stones
If your symptoms suggest kidney sto...
Source: Harvard Health Blog - July 18, 2019 Category: Consumer Health News Authors: Kevin R. Loughlin, MD, MBA Tags: Kidney and urinary tract Men's Health Women's Health Source Type: blogs
Funtabulously Frivolous Friday Five 286
Dr Neil Long Funtabulously Frivolous Friday Five 286
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 286 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - July 5, 2019 Category: Emergency Medicine Authors: Dr Neil Long Tags: FFFF alveolar echinoccosis Aragon benoates bituminous Brown-Sequard cinnamon Clenbuterol cystic echinococosis Diabetes mellitus erectile dysfunction Himalayas hydatid isease Lowenstein splint penile prothesis pi pie pylor Source Type: blogs
Predictors of heart failure in diabetes mellitus
Patients with diabetes mellitus are more prone to develop heart failure than others. Features of diabetes mellitus associated with the development of heart failure are:
Poor glycemic control
Longer duration of diabetes mellitus
Diabetes on insulin treatment
Presence of microvascular complications like retinopathy or nephropathy
Reference
Verma S, McMurray JJV. The Serendipitous Story of SGLT2 Inhibitors in Heart Failure. New Insights From DECLARE-TIMI 58. Circulation. 2019;139:2542–2553. (Source: Cardiophile MD)
Source: Cardiophile MD - June 4, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
