Fight Aging! Newsletter, November 19th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - November 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
mTORC1 at the Intersection of Aging and Type 2 Diabetes
For the vast majority of patients, type 2 diabetes is caused by the presence of excess visceral fat tissue, and can be reversed even at a late stage by losing that fat tissue. The degree to which one needs to abuse one's own body in order to become diabetic falls with advancing age, however. Aging makes type 2 diabetes more likely to occur, all other factors being equal. Looking at the relationship from the other direction, the chronic inflammation and other forms of metabolic dysfunction characteristic of type 2 diabetes accelerates the progression of aging. The condition shortens life expectancy and is associated with gr...
Source: Fight Aging! - November 14, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Nazi Anatomists - A Conversation with Aaron Fried | TAPP Episode 30
0:40 | Listen up: feedback on accommodating hearing impairment5:06 | HAPS is now a sponsor of this podcast!6:36 | Update in epigenetics10:07 | Handedness in cells13:45 |Featured: The Nazi Anatomists (a chat with Aaron Fried) If you cannot see or activate the audio playerclick here. FollowThe A&P Professor onTwitter,Facebook,Blogger,Nuzzel,Tumblr, orInstagram! 1 | Listen up!4.5 minutesFeedback from listener Ron Parente leads to a discussion of how accommodating for hearing impairments and other challenges actually help all learners —not just those needing accommodation. Have question...
Source: The A and P Professor - November 5, 2018 Category: Physiology Authors: Kevin Patton Source Type: blogs
Love those legumes!
“Legumes” sounds like such a fancy word. Let’s clarify that we’re talking about beans, folks. Beans, lentils, peas, chickpeas, it’s all good… and good for you. Legumes are amazingly nutritious, high in protein and fiber, low in fat, and low in glycemic load.
Legumes for heart health
Scientific studies have definitively linked a diet high in legumes with a lower risk of developing obesity, diabetes, high blood pressure, high cholesterol, heart disease, or strokes. As a matter of fact, eating legumes every day can effectively treat these diseases in people who already have them. In one randomized controlled c...
Source: Harvard Health Blog - October 25, 2018 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Food as medicine Healthy Eating Source Type: blogs
MKSAP: 25-year-old woman with type 1 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 25-year-old woman with type 1 diabetes mellitus is evaluated for recent-onset glycemic fluctuations without symptomatic hypoglycemia. She was diagnosed with diabetes 7 years ago. Her HbA1c levels since diagnosis have ranged from 6.4% to 7.3%, with the most recent value at 7.3%. She reports eating a carbohydrate-consistent diet at each meal, with little variation in her selection of meals or snacks. She started a new job several months ago but continues her daily exercise routine and sleep schedule. She has no ...
Source: Kevin, M.D. - Medical Weblog - September 22, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Endocrinology Source Type: blogs
MKSAP: 49-year-old woman with obesity, hypertension, and type 2 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 49-year-old woman is evaluated during a follow-up visit. She is overweight and has hypertension and type 2 diabetes mellitus, both of which are well controlled. For several years, she has attempted to lose weight through various commercial diets; dietician-monitored, calorie-restricted diets; and physical activity. She has worked with a behavioral therapist, and although she has not achieved weight loss, her weight has remained stable. She exercises 30 minutes daily. Medical history is also remarkable for glau...
Source: Kevin, M.D. - Medical Weblog - September 1, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Obesity Primary Care Source Type: blogs
MKSAP: 57-year-old man with type 2 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 57-year-old man with a 15-year history of type 2 diabetes mellitus is evaluated for bilateral burning sensation in his feet for the last 6 to 12 months. The sensation worsens at night. His HbA1c levels have remained less than 7.0% for the last 2 years but were between 8.0% and 9.0% before implementing significant lifestyle changes and transitioning to insulin therapy from metformin therapy 2 years ago.
His medical history includes coronary artery disease, first-degree atrioventricular block, nonproliferative d...
Source: Kevin, M.D. - Medical Weblog - August 11, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Endocrinology Neurology Source Type: blogs
Surrogate End Points Ain ’t all that Bad
By CHADI NABHAN MD MBA
Life is busy, yet we somehow find time to stay engaged on social media, remain engrossed in the 24/7 news cycle, and continue our futile efforts to resist clickbait. While social media can allow us to mindlessly scroll through feeds, it also provides an avenue to provoke vigorous dialogue, however diverse, controversial, or even rooted in unfettered biases. These exchanges have served as the primordial soup for virtual friend or foe-ships. Tense and argumentative Twitter exchanges are especially entertaining given the challenges in justifying a position in fewer than 280 characters. Thus, tweetorial...
Source: The Health Care Blog - August 9, 2018 Category: Consumer Health News Authors: at RogueRad Tags: EBM Source Type: blogs
Are useful notes in our future – the return of SOAP
CMS is changing note requirements, among other changes. Bob Doherty has a wonderful summary – FOUR things you should know about Medicare’s “historic” changes to physician payments
As always, we really will have a difficult time sorting out the unintended consequences of these changes, but they certainly seem like a move in the proper direction. To me the most important change is a focus on notes – “allowing medical decision making to be the basis for documentation, requiring physicians to only document changed information for established patients and to sign-off on basic information documented ...
Source: DB's Medical Rants - July 16, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
Compartment Syndrome Like You Haven’t Seen Before
The fascial planes in the upper and lower extremities play an important role in function and form, but they also make the extremities vulnerable to compartment syndrome. Emergency physicians are quite comfortable evaluating and diagnosing compartment syndrome: severe unrelenting pain, pain with passive motion of the muscle groups involved, and possibly paresthesias and pallor. The first patient I saw with this condition was at the Tripler Army Medical Center in Hawaii. A sailor dangling his legs over the dock presented after his leg was crushed between the dock and a battleship that suddenly shifted its position. I ...
Source: M2E Too! Mellick's Multimedia EduBlog - July 2, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
MKSAP: 70-year-old man with a transient ischemic attack
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 70-year-old man is admitted to the hospital with a 1-hour episode of left arm and left leg weakness. He is diagnosed with a transient ischemic attack. The patient has a history of hypertension and type 2 diabetes mellitus and a 30-pack-year history of smoking. Family history is noncontributory. His medications are metformin and lisinopril.
On physical examination, the patient is afebrile, and blood pressure is 148/88 mm Hg. The remainder of the examination is unremarkable.
Laboratory studies show alanine amino...
Source: Kevin, M.D. - Medical Weblog - June 30, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Cardiology Neurology Source Type: blogs
Statin adverse effect – Cardiology MCQ
Statin adverse effect/s with confirmed causality:
a) Myalgia/myopathy
b) Temporary elevation of alanine aminotransferase
c) New onset diabetes mellitus
d) All of the above
e) None of the above
Post your answer as a comment below. Correct answer will be published on: Jul 2, 2018 @ 05:59 (Source: Cardiophile MD)
Source: Cardiophile MD - June 30, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Another guideline problem – inaccurate CV risk estimation
This article – Recent Update to the US Cholesterol Treatment Guidelines summarizes the guideline. The guideline uses a risk calculator to guide lipid lowering (mostly statin) prescribing.
Many critics (including me) felt that the calculator greatly overestimated CV risk. Since the guideline depends on accurate estimation of that risk, testing and potentially improving the calculator has a high priority.
A recent Annals of Internal Medicine article – Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk – tests the original calculator again...
Source: DB's Medical Rants - June 25, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
MKSAP: 47-year-old man with hypertension, type 2 diabetes mellitus, and obstructive sleep apnea
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 47-year-old man is evaluated during a follow-up examination. He is obese and has hypertension, type 2 diabetes mellitus, and obstructive sleep apnea. He reports that he has always has been overweight, and over the years, his weight has gradually increased to 123 kg (271 lb). During the past 2 years, he has tried several commercial diets; a dietician-monitored, calorie-restricted diet; increased physical activity; orlistat; and a combination of these interventions, all without achieving sustained weight loss. M...
Source: Kevin, M.D. - Medical Weblog - May 26, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Primary Care Source Type: blogs
Senescent T Cells as a Contributing Cause of Age-Related Autoimmunity
We reported that a unique PD-1+ MP CD4+ T cell population is increased with age, now termed senescence-associated (SA-) T cells. The SA-T cells show characteristic signs and features of cellular senescence and emerge as follicular T cells in spontaneous germinal centers (GCs) that occur in aged mice. Spontaneous development of GCs is a hallmark of systemic autoimmune diseases, and among a number of changes in immune function with age is an increasing risk for autoimmunity.
Link: https://www.ncbi.nlm.nih.gov/books/NBK500331/ (Source: Fight Aging!)
Source: Fight Aging! - May 25, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
